Study of rheological behaviour of hydroxyethyl cellulose gels in the development of the composition and technology of the medicine with anti-inflammatory activity

Postoy, V. V.; Kukhtenko, H. P.; Vyshnevska, L. І.; Гладух, Є. В.; Semchenko, K. V.

doi:10.3897/pharmacia.66.e37267

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…The reason for the rheopecty is seen by some scientists in the fact that the parallel orientation of the elongated particles during the flow helps establishing bonds between them and thus promotes gel formation. Other scientists believe that the cause of rheopecty lies in the emergence of slight turbulence during the flow of a system -which accelerates the establishment of contact between the particles [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate

Popova

Kukhtenko

Гладух

et al. 2021

Current Issues in Pharmacy and Medical Sciences

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Every year, the number of cases of hypersensitivity to insect bites increases. Thus, particular attention needs to be paid to the treatment of insect allergy in children, as scratching the bites can complicate the healing process and lead to infection. Therefore, a topical issue for modern medicine and pharmacy is the development of a gel of combined anti-allergic, reparative and anti-inflammatory action for the treatment of local manifestations of allergic skin reactions. Rheological studies are one of the stages of pharmaceutical development of soft dosage forms. In this study, we perform rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol made on different carriers of dispersed structures: Carbopol™ Polymers carbomer Ultrez 10 NF, Hydroxypropyl methylcellulose (HPMC) of brand Metolose SR-90SH-100000SR, Ziboxan F200 xanthan gum. The rheological studies were undertaken using a rheometer in controlled shear rate mode CSR. Basic structural and mechanical indices of the dispersed systems were determined. These included: yield stress, structural viscosity, viscosity at infinite shear rate, the hysteresis loop area. Moreover, dynamic liquefaction coefficients have been calculated. Based on the rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol prepared with various carriers, the use of 1.8% and 2.0% HPMC hydrogels, 2.0% and 2.5% xanthan gum hydrogels, 0.5% and 0.75% carbomer gels is recommended for further biopharmaceutical studies. The application of one of these formulations as the final composition, provides adhesion and will not complicate the scaling-up of the process.

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Section: Discussionmentioning

confidence: 99%

Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate

Popova

Kukhtenko

Гладух

et al. 2021

Current Issues in Pharmacy and Medical Sciences

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“…An Anton Paar MCR 102 rheometer was used to assess the rheology of these mixes in line with the requirements of ISO 3219. 67 A CC27-type rotator with an effective height of 40 mm was used. Its inner and outer diameters were 26.661 and 28.913 mm, respectively.…”

Section: Materials and Methodologymentioning

confidence: 99%

Method for calculating dynamic yield stress of fresh cement pastes using a coaxial cylinder system

Peng

Unluer

et al. 2021

J. Am. Ceram. Soc.

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Fresh cement mixes are multiscale, multiphase, solid-liquid dispersion systems. 1 The individual particles in these mixes undergo irregular Brownian motion, collisions, and friction, and they exhibit electrostatic repulsion and Van der Waals forces. [2][3][4] In terms of rheological properties, cement paste shows more plastic properties when it is fresh. With continuous hydration, the cement paste gradually loses its fluidity, sets, and hardens into a semisolid or solid-phase system dominated by viscoelasticity. [5][6] The rheological properties strongly influence the macroscopic working performance of fresh cement-based materials. This performance can be characterized by specific rheological models that represent a functional relationship (i.e., a constitutive equation) between the shear stress and the shear rate of the flowing material. 7 For example, in the commonly used Bingham model, the two basic rheological parameters are the yield stress and plastic viscosity. [8][9] Meanwhile, the rheological properties reflect the change in the viscosity of the cement paste with variations in the external shear force. When the first derivative value of the shear

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Optimizing Nimesulide Loaded Cubosomal Gel for Enhanced Efficacy: A Systematic Engineering Approach with Factorial Design for Topical Applications

Deshmukh,

Pore,

Shikalgar

et al. 2024

J Pharm Innov

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Study of rheological behaviour of hydroxyethyl cellulose gels in the development of the composition and technology of the medicine with anti-inflammatory activity

Cited by 5 publications

References 2 publications

Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate

Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate

Method for calculating dynamic yield stress of fresh cement pastes using a coaxial cylinder system

Optimizing Nimesulide Loaded Cubosomal Gel for Enhanced Efficacy: A Systematic Engineering Approach with Factorial Design for Topical Applications

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