Study of S100 immunostaining in demonstrating neural granulomas in paucibacillary leprosy

Shenoy, Nandini; Nair, Nandakumar Gopinathan

doi:10.4103/ijd.ijd_207_17

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Because of the lack of studies investigating the neuropathic etiopathology of BMS, in particular using the S-100 protein, we also searched for parameters in studies on NF changes in other neuropathies, such as leprosy. 16,18 The S-100 protein has been suggested to be a superior strategy for the simultaneous identification of intact and fragmented nerve structures than H&E. 18 Furthermore, in leprosy cases, there is a 90.9% and 100% reduction of S-100 and PGP 9.5 immunoexpression for NF, respectively. These investigations also suggest that PGP 9.5 would be the best neuronal marker for the differentiation of intact nervous structures.…”

Section: Discussionmentioning

confidence: 99%

“…11 Neuronal proteins such as the gene product of protein 9.5 (PGP 9.5) and S-100 have been used to evaluate nerve structures in neuropathies. 6,13,[15][16][17][18] The hypothesis is that the early loss or nonexpression of PGP 9.5 seems to be associated with axonal degeneration processes, 15,17 as expected in neuropathies. PGP 9.5, a ubiquitin carboxydrolase, is expressed in axons and has been used to investigate neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 93%

“…It has also been used to analyze the general NF density in leprosy cases. 16,18 BMS is a globally burdensome oral condition that affects middle-aged or older individuals with a complex clinical diagnosis, and the available information about its etiopathogenesis is uncertain and controversial. 19 Although BMS is considered a small-fiber neuropathy, understanding of the disease mechanisms is still sparse.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of peripheral nerve fibers and mast cells in burning mouth syndrome

et al. 2023

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Emerging evidence has revealed a cross-talk in the etiopathogenesis of burning mouth syndrome (BMS) related to peripheral nerve fibers (NF) and neuropeptides secreted by mast cells.Here, we investigated the S-100 + density and PGP 9.5 + integrity of peripheral NF and the tryptase + mast cell density in the oral mucosa of BMS patients and healthy individuals. A total of 23 oral mucosa specimens (12 BMS and 11 controls) were evaluated. The clinical diagnosis of BMS was based on a careful examination, excluding other local and systemic causes. Samples were taken from an incisional biopsy of the tongue mucosa of individuals with symptomatic BMS, while the margins of the non-neoplastic tongue biopsy served as controls of healthy individuals. Immunohistochemistry was performed to determine the density/mm 2 of S-100 + , PGP 9.5 + peripheral NF, and tryptase + mast cells. Similar densities of S-100 + , PGP 9.5 + peripheral NF, and tryptase + mast cells were found in cases of BMS, with a median value of 3.70, 0.70, and 29.24/mm 2 , respectively, and in the control group, with a median value of 2.60, 0.80, and 26.01/mm 2 , respectively (p > 0.05). Moreover, the relationship between S100 + and PGP 9.5 + peripheral NF was the same in both groups (p = 0.70). This study demonstrated that there were no alterations in the density and integrity of peripheral NF in the tongue of symptomatic BMS patients. However, the sensitization of peripheral NF in this disease may not depend on mast cell density.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Evaluation of peripheral nerve fibers and mast cells in burning mouth syndrome

et al. 2023

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Role of S100 immunostaining in demonstrating neural granulomas in paucibacillary leprosy

Mohapatra

Das

Chakraborty

2020

J NTR Univ Health Sci

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Histopathological Spectrum of Granulomatous Skin Lesions: A Review

George¹

2019

SBV Journal of Basic, Clinical and Applied Health Science

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Background and objectives: Granulomatous dermatoses are the most frequently encountered dermatological disorders in tropical countries with leprosy and tuberculosis as the leading causes. Although granulomatous skin lesions are very prevalent in society today, dermatopathologists often face diagnostic challenges while reporting these lesions due to the similar histopathological features or tissue reaction patterns seen in these lesions with diverse etiologies. The purpose of this study is to review the various causes and patterns of granulomatous skin lesions and a sequential approach to diagnosis of individual lesions accurately. Materials and methods: A comprehensive search of all literature available on granulomatous skin diseases between 2000 and 2018 was conducted, using keywords such as "granulomatous dermatosis, " "cutaneous tuberculosis, " "leprosy, " and "histopathological study" in the databases such as PubMed, ProQuest, and Google Scholar. The articles that satisfied the criteria were included in the final review. Results: The available evidence from the existing systematic literature reviews and articles suggested that the various tissue reaction patterns observed in granulomatous skin lesions are classified as epithelioid, palisaded, suppurative, xanthogranulomatous, foreign body, and other granulomatous patterns. These tissue reaction patterns are caused by infections, foreign bodies, metabolites, chemicals, and malignancies. Conclusion: Granulomatous dermatoses are a heterogeneous group of skin disorders that are frequently encountered in diagnostic dermatopathology. The histomorphology of a granuloma has to be correlated with the clinical history and ancillary techniques including special stains, culture, and molecular methods are necessary to arrive at a definitive diagnosis.

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Study of S100 immunostaining in demonstrating neural granulomas in paucibacillary leprosy

Cited by 3 publications

References 4 publications

Evaluation of peripheral nerve fibers and mast cells in burning mouth syndrome

Evaluation of peripheral nerve fibers and mast cells in burning mouth syndrome

Role of S100 immunostaining in demonstrating neural granulomas in paucibacillary leprosy

Histopathological Spectrum of Granulomatous Skin Lesions: A Review

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