Study of scavenging capacity of naringin extracted from citrus uranium peel against free radicals

Díaz‐Uribe, Carlos; Vallejo, William; Oliveros, Grace; Muñoz, Amner

doi:10.15665/rp.v14i2.677

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Naringin is a flavonoid found in citrus fruits, which has been reported to not only have lipid-lowering activity but also exhibits anti-oxidative capability against oxidative stress and contains natural antioxidant properties [ 14 ]. This study showed that naringin has strong antioxidant activities for scavenging free radicals, which were determined by ABTS, DPPH radical scavenging assay, and total phenolic content, which is consistent with a report by Vallejo [ 37 ]. The results showed that the rats that received 50 and 100 mg/kg of naringin had increased levels of SOD and CAT activities in the skeletal muscle tissues when compared with the HFD group.…”

Section: Discussionsupporting

confidence: 92%

Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

et al. 2022

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Obesity causes progressive lipid accumulation and insulin resistance within muscle cells and affects skeletal muscle fibres and muscle mass that demonstrates atrophy and dysfunction. This study investigated the effects of naringin on the metabolic processes of skeletal muscle in obese rats. Male Sprague Dawley rats were divided into five groups: the control group with normal diet and the obese groups, which were induced with a high-fat diet (HFD) for the first 4 weeks and then treated with 40 mg/kg of simvastatin and 50 and 100 mg/kg of naringin from week 4 to 8. The naringin-treated group showed reduced body weight, biochemical parameters, and the mRNA expressions of protein degradation. Moreover, increased levels of antioxidant enzymes, glycogen, glucose uptake, the expression of the insulin receptor substrate 1 (IRS-1), the glucose transporter type 4 (GLUT4), and the mRNA expressions of protein synthesis led to improved muscle mass in the naringin-treated groups. The in vitro part showed the inhibitory effects of naringin on digestive enzymes related to lipid and glucose homeostasis. This study demonstrates the potential benefits of naringin as a supplement for treating muscle abnormalities in obese rats by modulating the antioxidative status, regulating protein metabolism, and improved insulin resistance in skeletal muscle of HFD-induced insulin resistance in obese rats.

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Section: Discussionsupporting

confidence: 92%

Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

et al. 2022

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“…Typical peaks at 928cm −1 , 837 cm −1 , 779 cm −1 , was assigned to the configuration of α-glycosides [43,44], characteristic absorption bands at 1245 cm -1 (S=O stretching vibration) confirmed the presence of sulfate groups, a band at 1070.96 suggest the presence of C-O bonds [45]. The infrared spectrum of naringin in KBr pellets showed characteristic bands, the OH group at 3411.61 cm -1 , the C-H at 2926.49 and 2861.55 cm -1 [46], the band at 1729 cm -1 which indicated presence of C=O the carbonyl stretching vibration of the carboxyl group (COO), The infrared bands around 1626 cm -1 which indicated the C=C stretching that is attributed to the presence of aromatic or benzene rings. The vibrational bands at around 1457.86 cm -1 were aliphatic and aromatic (C-H) group.…”

Section: Resultsmentioning

confidence: 92%

Isolation, Characterization and the Biological Activity of Some Natural Components of Marine Sea Cucumber and Orange Peel

Barky¹

2020

BJSTR

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Natural components thought to have a particular benefit nowadays. They are playing a necessary role in health attention. Sea cucumber is theorized to be a significant source of bioactive components. Moreover, Flavonoid glycosides are a group of polyphenols with different glycoside substituent that possesses diverse pharmacological activities and can help management coronavirus. So, this study aimed to extract saponin and polysaccharides from sea cucumber, also, extract both of naringin, hesperidin from orange peel and convert hesperidin to hesperetin then chemical analysis of all extracted compounds was performed to confirm their structure and evaluate their antioxidant, antibacterial and antitumor activity. The concentrations of saponin, naringen, hesperidin, hesperetin, and ascorbic acid, which scavenged 50% of DPPH radicals, were 10.50, 0.13, 0.13, 0.66, and 0.0025 mg/ml respectively. Furthermore, Cell viability of saponin, hesperidin and hespertin showed a growth inhibitory effect, IC50 28.78, 236.40 and 73.99. The obtained data indicated that sea cucumber saponin, polysaccharides, and orange peels, may provide a promising new therapeutic approach to HEPG2 cancer cells. Also, these compounds were effective antioxidant, so they may be effective and scavenge free radicals which resulted from the disease.

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“…On the other hand, the regulation of inflammation provides the necessary environment for the differentiation of fibroblasts to myofibroblasts to be accelerated, thus leading to greater contraction in the wound. Every ChEEP fraction demonstrated antioxidant activity due to phenolic compounds [64][65][66][67][68][69][70][71][72][73][74][75][76], which can reduce ROS levels and therefore prevent oxidative stress in the scar area, generating a microenvironment favourable for healing.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mexican Propolis on Wound Healing in a Murine Model of Diabetes Mellitus

Canales-Alvarez,

Canales-Martinez,

Dominguez-Verano

et al. 2024

IJMS

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Diabetes mellitus (DM) affects the wound healing process, resulting in impaired healing or aberrant scarring. DM increases reactive oxygen species (ROS) production, fibroblast senescence and angiogenesis abnormalities, causing exacerbated inflammation accompanied by low levels of TGF—β and an increase in Matrix metalloproteinases (MMPs). . Propolis has been proposed as a healing alternative for diabetic patients because it has antimicrobial, anti-inflammatory, antioxidant and proliferative effects and important properties in the healing process. An ethanolic extract of Chihuahua propolis (ChEEP) was obtained and fractionated, and the fractions were subjected to High–Performance Liquid Chromatography with diode–array (HPLC–DAD), High–Performance Liquid Chromatography–Mass Spectrometry (HPLC–MS) and Gas Chromatography‒Mass Spectrometry (GC–MS) analyses and 46 compounds were detected. Deep wounds were made in a murine DM model induced by streptozotocin, and the speed of closure and the wound tensile strength were evaluated by the tensiometric method, which showed that ChEEP had similar activity to Recoveron, improving the speed of healing and increasing the wound tensile strength needed to open the wound again. A histological analysis of the wounds was performed using H&E staining, and when Matrix metalloproteinase 9 (MMP9) and α—actin were quantified by immunohistochemistry, ChEEP was shown to be associated with improved histological healing, as indicated by the reduced MMP9 and α—actin expression. In conclusion, topical ChEEP application enhances wound healing in diabetic mice.

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Study of scavenging capacity of naringin extracted from citrus uranium peel against free radicals

Cited by 9 publications

References 18 publications

Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats

Isolation, Characterization and the Biological Activity of Some Natural Components of Marine Sea Cucumber and Orange Peel

Effect of Mexican Propolis on Wound Healing in a Murine Model of Diabetes Mellitus

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