Study of Seroprevalence of Dengue Virus Infection in a Tertiary Care Hospital in Patan, Gujarat, India

Nisarta, Ankita; Ahir, Hitesh R

doi:10.20546/ijcmas.2016.510.089

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…The sensitivity of Dengue NS1 Rapid ICT when compared with ELISA was found to be 93.6% and specificity was found to be 100% ( 13 ., 2012 and a greater prevalence among the adult population. Ankita Nisarta et al 14 reported that females were more commonly affected than males with male to female ratio of 1:1.35 in contrast to our study (Figure 1: Demographic analysis of the positive samples). The prevalence of NS1 antigen was found to be 36.5% from our study which is similar to the studies conducted by J.V.…”

Section: Resultscontrasting

confidence: 90%

Comparison of the Diagnostic Efficacy of Rapid Immunochromatographic Test with Microwell ELISA in the detection of Dengue NS1 Antigen - A Retrospective Study

Krithikaa¹,

Raj²,

arasi³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Section: Resultscontrasting

confidence: 90%

Comparison of the Diagnostic Efficacy of Rapid Immunochromatographic Test with Microwell ELISA in the detection of Dengue NS1 Antigen - A Retrospective Study

Krithikaa¹,

Raj²,

arasi³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Dengue infection in India: A systematic review and meta-analysis

et al. 2018

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IntroductionDengue is the most extensively spread mosquito-borne disease; endemic in more than 100 countries. Information about dengue disease burden, its prevalence, incidence and geographic distribution is critical in planning appropriate control measures against dengue fever. We conducted a systematic review and meta-analysis of dengue fever in IndiaMethodsWe searched for studies published until 2017 reporting the incidence, the prevalence or case fatality of dengue in India. Our primary outcomes were (a) prevalence of laboratory confirmed dengue infection among clinically suspected patients, (b) seroprevalence in the general population and (c) case fatality ratio among laboratory confirmed dengue patients. We used binomial–normal mixed effects regression model to estimate the pooled proportion of dengue infections. Forest plots were used to display pooled estimates. The metafor package of R software was used to conduct meta-analysis.ResultsOf the 2285 identified articles on dengue, we included 233 in the analysis wherein 180 reported prevalence of laboratory confirmed dengue infection, seven reported seroprevalence as evidenced by IgG or neutralizing antibodies against dengue and 77 reported case fatality. The overall estimate of the prevalence of laboratory confirmed dengue infection among clinically suspected patients was 38.3% (95% CI: 34.8%–41.8%). The pooled estimate of dengue seroprevalence in the general population and CFR among laboratory confirmed patients was 56.9% (95% CI: 37.5–74.4) and 2.6% (95% CI: 2–3.4) respectively. There was significant heterogeneity in reported outcomes (p-values<0.001).ConclusionsIdentified gaps in the understanding of dengue epidemiology in India emphasize the need to initiate community-based cohort studies representing different geographic regions to generate reliable estimates of age-specific incidence of dengue and studies to generate dengue seroprevalence data in the country.

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Dengue Seroprevalence in Different Geographic Zones of India: A Systematic Review and Meta-Analysis of Cross-Sectional Studies

Panda,

Patra,

Bindhani

et al. 2024

J. Pure Appl. Microbiol.

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Dengue is a highly prevalent mosquito-borne disease that is endemic in over 100 countries. It has a wider impact in terms of severity of illness and mortality risk in the absence of an effective vaccine as yet. The purpose of this study was to use meta-analysis to find out how common the dengue virus (DENV) is in India based on public data and to figure out how much of a problem. We searched, read, and reviewed about DENV in India that were available online. Forty-four cross-sectional studies were selected from the 178 records. There were reports of dengue cases in 14 out of the 28 states. Out of the patients presenting with symptoms of Dengue 27% of people were confirmed to have DENV infection with 82.29% (95% CI. 81-84%), having dengue IgM, 41.67% (95% CI: 40.16-43.43), having dengue IgG, and 23.97% (95% C.I. 14-43%), having both IgG and IgM from positive sample n=27156. Hospital-based cross-sectional studies on suspected Dengue-like illness (DLI) found that 99.48% of people had confirmed dengue out of the patients with features of DLI, and community-based studies found that 0.52% of DLI cases had dengue. The seroprevalence rates for East, South, North, and Western regions were 35.38% (95% C.I.14-31%), 11.57% (95% C.I. 2-69%), 38.10% (95% C.I. 9-61%), and 14.87% (95% C.I. 6-38%) correspondingly. DENV is interestingly spreading across the whole country, and the disease’s frequency varies a lot from place to place and from 2010-2023. However this review does not find appropriate published literature from 50% of the Indian states. The identification of IgG-class antibodies to dengue virus is indicative of prior exposure to this pathogen. Almost all immunocompetent individuals should have developed IgG antibodies against the dengue virus within three weeks of exposure. The presence of dengue virus IgM-class antibodies is indicative of an acute phase of infection. National Vector borne Disease Control Programme (NVBDCP) has some surveillance information, appropriate designed research into prevalence and risk factors for DENV infection would be required to provide adequate information for public health intervention.

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Study of Seroprevalence of Dengue Virus Infection in a Tertiary Care Hospital in Patan, Gujarat, India

Cited by 3 publications

References 12 publications

Comparison of the Diagnostic Efficacy of Rapid Immunochromatographic Test with Microwell ELISA in the detection of Dengue NS1 Antigen - A Retrospective Study

Comparison of the Diagnostic Efficacy of Rapid Immunochromatographic Test with Microwell ELISA in the detection of Dengue NS1 Antigen - A Retrospective Study

Dengue infection in India: A systematic review and meta-analysis

Dengue Seroprevalence in Different Geographic Zones of India: A Systematic Review and Meta-Analysis of Cross-Sectional Studies

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