Study of serum creatine kinase and lactate dehydrogenase levels and their correlation in high-voltage electric contact burns

Babu, Vaddi Suman; Sharma, Sonam; Manas, Raj Kumar; Kaur, Charanjeet; Rajkumar, Rahul

doi:10.1007/s00238-020-01695-z

Cited by 2 publications

(8 citation statements)

References 19 publications

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“…Taking into account the frequencies of the appearance of each of the signs and symptoms, location of the biopolymers in different planes, and pathophysiology of the clinical behavior of the disease, the Pachón classification proposes taking five parameters into consideration: (1) diagnostic imaging findings (MRI), (2) local clinical signs, (3) systemic symptoms, (4) systemic clinical signs, and (5) autoimmune markers (Table 5). [8][9][10][11][12][13][14][15] This assessment makes it possible to generate a score that categorizes the biopolymer carrier patient with a stage of the disease (mild, moderate, or severe), which in turn allows us to establish an individualized treatment plan (Tables 6, 7).…”

Section: Resultsmentioning

confidence: 99%

“…The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each of the signs and symptoms were calculated for being positive for antinuclear antibodies, lactate dehydrogenase, and lupus anticoagulant. The results are presented in tables and graphs, supported by images of the different skin stages 8–11 (Figs. 1–5).…”

Section: Methodsmentioning

confidence: 93%

“…13,14 These aspects have been previously described in other medical conditions of metabolic or autoimmune origin. 18,19 Lactate dehydrogenase is a factor of severity in the behavior of the biopolymer [9][10][11] and makes it possible to define an early surgical approach, mitigating the symptoms and chronic inflammatory behavior of the disease. 3 As a limitation of the study, it is considered that a control group was missing to compare and generate the association between immunological markers and human adjuvant disease caused by biopolymer that would allow us to give more power to the diagnostic decision measures.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…positive for antinuclear antibodies, lactate dehydrogenase, and lupus anticoagulant. The results are presented in tables and graphs, supported by images of the different skin stages [8][9][10][11] (Figs. 1-5).…”

Section: Takeawaysmentioning

confidence: 95%

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Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease

Suárez¹,

Salazar²,

Rizo³

2022

Plastic and Reconstructive Surgery - Global Open

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Background: Biopolymer-induced human adjuvant disease (BHAD) is a chronic clinical condition that requires surgical intervention, regardless of the presence of symptoms, to minimize the risk of functional, aesthetic, and systemic sequelae and the development of conditions simulating autoimmune disease. We propose a classification for BHAD on the basis of course of the disease, which will make it possible to assess the damage and difficulty in patients, leading to a more appropriate therapeutic approach. Methods: A protocol study was implemented. A casuistry of patients with a diagnosis of autoimmune/inflammatory syndrome induced by adjuvants was taken into account according to the Shoenfeld criteria. Qualitative variables were analyzed through frequencies and percentages, and quantitative variables were analyzed with measures of central tendency and dispersion. The diagnostic validity of the signs and symptoms was analyzed using some paraclinical tests. Results: A total of 190 patients diagnosed with autoimmune/inflammatory syndrome induced by adjuvants with biopolymers in the buttocks and who underwent a surgical procedure by the open, masked technique between January 2017 and December 2020 were selected. Considering each sign and symptom, the location of the biopolymers in different planes, and pathophysiology of the clinical course of the disease, a classification was proposed that takes into account diagnostic imaging findings, local clinical signs, systemic symptoms, systemic clinical signs, and autoimmune markers. Conclusion: Some signs associated with biomarkers with sensitivity and specificity values can influence the pretest decision to request paraclinicals, improving the diagnostic probability and cost effectiveness in these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Takeawaysmentioning

confidence: 95%

See 3 more Smart Citations

Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease

Suárez¹,

Salazar²,

Rizo³

2022

Plastic and Reconstructive Surgery - Global Open

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Effect of early excision of a burn wound on the activity of selected enzymes in pig serum

Aleksiewicz¹,

Lutnicki²,

TUREK³

2022

Medycyna Weterynaryjna

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Thermal stimuli acting on the skin can cause burn wounds. Clinical and experimental studies suggest a beneficial effect of the necrectomy of post burn necrosis in the hyperacute phase and in the acute phase (during the initial period of burn disease). Heat stroke causes hypovolemic shock and influences the energetic status of the liver, which is the main organ responsible for energy production and energy storage. Determination of the activity of indicator enzymes in serum makes it possible to assess the clinical condition of animals. A total of 25 White Large Landrace pigs of both sexes weighing 50 kg (± 2 kg) were used for the study. Burns were made with a software-controlled heating plate on a precisely defined contact surface of 1% of body surface. This resulted in a burn rate of 30% (± 2%) of the body surface with a lesion range between grades III and IIb. Animals from each experimental group were subjected to an infraclavicular necrectomy. Blood was collected and analyzed for AlAT, AspAT, LDH, and CK activities. In all groups, a statistically significant (p <0.05) increase in AlAT, AspAT, LDH, and CK activities was observed already 12 hours after the burn, and there was a very high correlation between the activities of parenchymal enzymes AlAT and AspAT. The study has shown an association between the moment of performing burn wound necrectomy and the activity of AlAT, AspAT, LDH, and CK.

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Study of serum creatine kinase and lactate dehydrogenase levels and their correlation in high-voltage electric contact burns

Cited by 2 publications

References 19 publications

Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease

Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease

Effect of early excision of a burn wound on the activity of selected enzymes in pig serum

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