Study of Serum Metabolic Biomarkers and Prediction Models of Cantharidin‐Induced Nephrotoxicity in Rats Based on Dynamic Metabolomics
Weina Cheng,
Wenzhong Feng,
Guanghuan Tian
et al.
Abstract:The clinical application of cantharidin (CTD) is seriously limited due to its nephrotoxicity. Therefore, this study aims to investigate sensitive biomarkers for the evaluation and prediction of nephrotoxicity induced by CTD in rat. A total of 80 rats were randomly divided into four groups: control group and three doses of CTD groups. After 0, 1, 5, 15, and 28 days of intragastric administration, rat serum and urine were collected for biochemical indexes, then serum was used for metabolomic analyses, and rat ki… Show more
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