Study of Serum Total PSA and Free  PSA as an Oncological Marker in Breast  Tumour

Jahir, Elteza Tahjiba; Devi, Runi; Borthakur, Bibhuti Bhusan

doi:10.7860/jcdr/2017/22111.9543

Cited by 2 publications

(3 citation statements)

References 20 publications

(2 reference statements)

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“…Уменьшение уровней общПСА также было отмечено при снижении степени дифференцировки опухоли: от 1,813 нг/мл при высокодифференцированном РМЖ до 1,070 нг/мл -при низкодифференцированном. Снижение свПСА оказалось не столь выраженным: от 1,149 нг/мл при высокодифференцированных опухолях до 1,002 нг/мл -при низкодифференцированных [47]. Более высокие уровни общПСА и свПСА были ассоциированы с молодым возрастом (менее 50 лет) и пременопаузальным статусом больных РМЖ [43,46].…”

Section: применение общпса и свпса в диагностике рмжunclassified

Prostate-Specific Antigen and Its Molecular Forms in Blood Serum of Healthy Women and Women With Breast Disease

Сергеева¹,

Алентов²,

Ortabaeva³

et al. 2020

Sib. onkol. ž.

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Section: применение общпса и свпса в диагностике рмжunclassified

Prostate-Specific Antigen and Its Molecular Forms in Blood Serum of Healthy Women and Women With Breast Disease

Сергеева¹,

Алентов²,

Ortabaeva³

et al. 2020

Sib. onkol. ž.

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“…Повышенные, по сравнению со здоровыми женщинами, значения ПСА наблюдаются в части случаев при доброкачественных заболеваниях молочной железы и при РМЖ [11][12][13][14][15][16]. Обнаруженное в ряде исследований снижение уровня общего ПСА у больных РМЖ после мастэктомии, по мнению авторов, косвенно указывает на то, что источником повышенного содержания антигена в крови пациенток в этих случаях являлась пораженная опухолью молочная железа [4,[12][13][14].…”

Section: Introductionunclassified

“…Обращает на себя внимание, что у больных РМЖ женщин отмечают обратную корреляцию между содержанием общего ПСА в сыворотке крови и стадией заболевания [4,17,18], размером опухоли [13,17], а также степенью дифференцировки новообразования [16]. Такой характер корреляций дает основания полагать, что повышенный уровень ПСА преимущественно ассоциирован с ранними формами заболевания.…”

Section: Introductionunclassified

Clinical Significanse of Prostate-Specific Antigen in Breast Cancer Patients

et al. 2020

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Background. Prostate-specific antigen (PSA ) is predominantly produced by prostate epithelium, however, other tissues can serve as its minor sources in both men and women, including breast tissue. In women, elevated serum PSA levels have been described in different physiological and pathological conditions, including benign breast diseases and breast cancer (BC). PSA is considered as a potential serum tumor marker for BC, but evidences of its possible clinical significance are insufficiently convincing.Aim of the study: investigation of PSA levels in female BC patients and assessment of perspectives of its study as a diagnostic tool for early detection of BC.Material and methods. Serum PSA levels were measured by chemiluminescence immunoassay (ARCHITECT , Abbott) in 99 female patients with histologically confirmed BC (carcinoma in situ – 11, stage I – 56, stage IIA – 32) and 25 conditionally healthy female donors.Results. In the donor group, serum PSA was revealed in 22/25 (88,0 %) cases, and its mean level was 4.0 ± 0.9 ng/l. In the group of BC patients, detectable PSA level was revealed in 68/99 (68.7 %) cases, and its mean level was 2.8 ± 0.9 ng/l. Differences between groups of BC patients and donors in mean marker values were not statistically significant (p>0,05). Serum PSA levels were higher in young women: in the group of BC patients under 40 years old, percentage of PSA -positive cases was 89 %, in the group of patients over 50 years old – 60 %; in groups of donors under 40 and over 50 years old – 100 % and 80 %, respectively. In cases of in situ carcinoma, the mean serum PSA was higher than in cases with stages I and II (3.0 ± 1.2 ng/l vs 1.9 ± 0.3 ng/l and 1.6 ± 0.3 ng/l, respectively; p>0,05). In the group of BC patients, no PSA levels were found to be dependent on the histological type, grade and molecular subtype of the tumor.Conclusion. The PSA level has no clinical significance in early stages of BC, since the proportion of cases with elevated PSA levels and it’s mean value in patients with early stages of BC don’t differ from those in the group of healthy women.

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Study of Serum Total PSA and Free PSA as an Oncological Marker in Breast Tumour

Cited by 2 publications

References 20 publications

Prostate-Specific Antigen and Its Molecular Forms in Blood Serum of Healthy Women and Women With Breast Disease

Prostate-Specific Antigen and Its Molecular Forms in Blood Serum of Healthy Women and Women With Breast Disease

Clinical Significanse of Prostate-Specific Antigen in Breast Cancer Patients

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