Study of serum transferrin and serum ferritin during pregnancy and their correlation with pregnancy outcome

Kumar, Shailesh; Dubey, Namrata; Khare, Ruchir

doi:10.5455/ijmsph.2017.04072016570

Cited by 5 publications

(5 citation statements)

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“…Low socioeconomic conditions are to be pointed out as well due to inappropriate nutritional intake along with bad hygienic conditions that favour hookworms infestation. This corroborates other studies carried out in similar environments [11] [ ng/ml, respectively) [20] and India (mean serum ferritin of 60.42 ± 20.24 -47.33 ± 13.49 ng/ml) [21], but lower than values from wealthy environments (26 -38 ng/ml for ferritin) [22]. Ferritin reflects iron storage in the body, and it is claimed that in the absence of inflammatory situation the lowest levels are close to 15 ng/ml [23].…”

Section: Discussionsupporting

confidence: 92%

Baseline Iron Status and Indices of Oxidative Stress in a Cohort of Pregnant Women in Kinshasa, DR Congo

Mbangama¹,

Tandu-Umba²,

Roger³

2018

OJOG

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Objective: To determine baseline iron and oxidative status in a cohort of pregnant women before iron supplementation in our setting. Background: Screening of iron deficiency before supplementation during pregnancy has been scarce. Therefore, following routine iron supplementation confounding results might be found in outcomes of groups of patients considered. Taking in account that body/serum iron status is reportedly linked to maternal oxidative status, we aimed to associate assessment of baseline iron and oxidative status of women in need of oral supplementation during pregnancy. Methods: This is a cross-sectional study concerning 74 women attending antenatal care at the University Clinics of Kinshasa from September 2017 throughout June 2018, with a singleton pregnancy not exceeding 19 weeks, regardless of age and parity. Variables of the study included sociodemographic and anthropometric ones along with parameters of iron status (hemoglobin, hematocrit, ferritin, serum iron, transferrin and iron saturation capacity). Oxidative status was assessed using superoxide dismutase (SOD) and uric acid as antioxidants, while oxidant agents were oxidized LDL and blood glucose (beside serum iron and ferritin). According to local standards anemia was defined as hemoglobin < 10 g/L and pathologic serum ferritin as < 15 ng/ml. For statistical calculations we used t-test, chi-square test and Pearson's correlation test, the significance being stated at p ≤ 0.05. Results: At recruitment (15.9 ± 1.7 9 week gestational age) mean hemoglobin value of the overall study group was 10.3 ± 1.5 g/dl. Anemia was diagnosed to 39 women that represented 52.2% of the study group, most of anemic women belonging to low socioeconomic sub-group (69.2% vs 29%; P < 0.001). The majority was para 2, with average weight of 70.2 ± 14.5 Kg (P not significant between sub-groups) and BMI of 26 ± 5.2 Kg/m 2 (P < 0.01).higher among anemic women (61.5% vs 34.3%; P < 0.02) that had lower alimentary iron intake (22.8 ± 4.9 gr/day vs 31.4 ± 9.5 gr; P < 0.001). Of markers of iron status serum ferritin and iron were lower in anemic women (7.5 ± 3.9 ng/ml vs 35.7 ± 17.1 ng/ml; P < 0.001 and 52.7 ± 38.9 μg/dl vs 96.2 ± 41.8 μg/dl, respectively. Both sub-groups were similar in serum transferrin. As of markers of oxidative stress anemic women had significantly higher superoxide dismutases (SOD) (1056.4 ± 762.1 UI/L vs 682.6 ± 543.9 UI/L (P < 0.02) and oxidizedd anti LDL Ac (439.6 ± 209.5 UI/L vs 192.8 ± 136.3 UI/L (P < 0.001). Serum iron, ferritin, SOD and oxidized LDL were more likely to assess iron and oxidative status in our setting. Conclusion: The rate of anemic mothers found in our study (52.2%) has been quite constant in our setting for years, meaning endemicity. Serum iron and ferritin were significantly lower in anemic women, which is supportive of routine iron supplementation during pregnancy. Significantly higher level of SOD and oxidized LDL in anemic women suggests that maternal anemia may count into oxidative stress likely to be found in these women.

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Section: Discussionsupporting

confidence: 92%

Baseline Iron Status and Indices of Oxidative Stress in a Cohort of Pregnant Women in Kinshasa, DR Congo

Mbangama¹,

Tandu-Umba²,

Roger³

2018

OJOG

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“…However, a recent study found that pregnant women in all trimesters had low level of ferritin serum [25]. The limitation of our study is small number of subjects that is being analyzed due to the geographical factor of area where most of them live in fishing villages that have limited access to the clinic.…”

Section: Discussionmentioning

confidence: 92%

Comparison of Maternal Outcomes of Daily and Weekly Iron Tablet Supplementation in Pregnant Women in Coastal Region, Medan, Indonesia

Yaznil¹,

Lubis²,

Lumbanraja³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Weekly consumption of iron supplementation is preferred to daily consumption of iron supplementation because of its minimal side effects and higher level of compliance. AIM: This study is to compare the maternal outcomes in pregnant women with daily and weekly consumption of iron supplementation in coastal region. METHODS: This prospective cohort study was conducted from July 2018 to January 2019 in Belawan Health Center and Medan Deli Health Center. Sixty-two pregnant women who met inclusion and exclusion criteria were given iron supplement everyday (Group 1, n = 29) and twice a week (Group 2, n = 33). Hemoglobin levels, hematocrit, and ferritin serum are tested before starting the iron supplementation. All numerical data were analyzed using t-test. RESULTS: There is no significant difference in mean hemoglobin and hematocrit before and after iron supplementation p = 0.222 and p = 0.793, respectively, however, decreasing level of ferritin serum from 41.21 to 26.29 ng/ml (p = 0.001) is found. Hemoglobin, hematocrit, and ferritin serum means, before and after supplementation were not statistically different between daily and weekly group (p = 0.421, p = 0.197, p = 0.917). CONCLUSION: To prevent iron deficiency anemia in pregnant women, weekly or daily iron supplementation show similar effectiveness although continuous consumption of iron supplementation during breastfeeding period is needed to restore iron loss during pregnancy.

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“…Yaznil MR and colleagues also found in their study that there is no significant difference in mean haemoglobin and hematocrit between daily and weekly groups before and after iron supplementation. 15 Weekly iron supplementation as a prophylaxis in non-anaemic pregnant women is as good as daily supplementation as regards the increase in haemoglobin level, in addition, it was associated with significantly fewer side effects and much better compliance 16,17,18,19 .…”

Section: Resultsmentioning

confidence: 99%

Comparison Of The Effectiveness Of Daily Versus Weekly Oral Iron Supplementation In Preventing Anemia During Pregnancy

Sadaf,

Iqbal,

Ahmed

et al. 2023

JRMC

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Introduction: Daily oral iron and folic acid intake is recommended as part of antenatal care but adherence to this regimen, due to gastrointestinal side effects, interrupted intake of iron. Weekly oral iron therapy has been introduced as an alternative to the daily iron regimen. Objective: To compare mean hemoglobin and hematocrit in non-anemic pregnant females receiving daily oral iron versus weekly iron supplements in third trimester of pregnancy. Material and Methods This randomized Controlled Trial study was carried out in department of obstetrics and gynecology of holy family hospital, Rawalpindi during 20th November 2019 to 20th May 2020. 70 pregnant females of 15 to 45 years, with singleton pregnancies, at gestational amenorrhea 14 to 22 weeks at the time of inclusion with hemoglobin level 11g/dl and above were included. They were randomly divided into two equal groups using SPSS, Group A (35) received daily oral iron and Group B, 35 received weekly oral iron. Results: There was no statistically significant difference could be detected between both groups as regards the hemoglobin level before starting iron supplementation and duration of supplementation and this can be attributed to proper randomization. Mean post treatment hemoglobin was 13.2±0.93 g/dl in group A and 12.9±0.95 g/dl in group B (0.118), mean change of hemoglobin was 1.07±0.34 g/dl in group A and 0.63±0.56 g/dl in group B (0.000), mean post treatment hematocrit was 35.857±0.87 % in group A and 32.857±0.91 % in group B (p 0.000), mean change of hematocrit was 2.942±0.59 % in group A and 1.000±0.00 % in group B (p 0.000). Conclusion: Weekly iron supplementation as a prophylaxis in non-anemic pregnant women is as good as daily supplementation as regards the hemoglobin level.

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Study of serum transferrin and serum ferritin during pregnancy and their correlation with pregnancy outcome

Cited by 5 publications

References 0 publications

Baseline Iron Status and Indices of Oxidative Stress in a Cohort of Pregnant Women in Kinshasa, DR Congo

Baseline Iron Status and Indices of Oxidative Stress in a Cohort of Pregnant Women in Kinshasa, DR Congo

Comparison of Maternal Outcomes of Daily and Weekly Iron Tablet Supplementation in Pregnant Women in Coastal Region, Medan, Indonesia

Comparison Of The Effectiveness Of Daily Versus Weekly Oral Iron Supplementation In Preventing Anemia During Pregnancy

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