Study of serum visfatin level in patients with nonalcoholic fatty liver disease and its role in progression to nonalcoholic steatohepatitis

Riad, George S.; Hussein, Hany A.; Ghafar, Ahmed Z. Abdel

doi:10.1097/01.elx.0000544522.99768.5b

Cited by 1 publication

(1 citation statement)

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“…The association of RBP4 levels with NAFLD is still conflicting. Many studies finding correlation between RBP4 with NAFLD in the general population, some of these studies supported that RBP4 levels increased and significantly correlated with NAFLD (17)(18)(19), while others found that RBP4 independently positively correlated with NAFLD (20,21). Other studied reported that RBP4 levels significantly decreased in NAFLD patient (22).…”

Section: Resultsmentioning

confidence: 94%

Relation of retinol binding protein4, visfatin and vitamin a in obese and non obese Iraqi patients with non alcoholic fatty liver disease

Sattar

AL-Sa’adi

2022

ijhs

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One of the most common public liver diseases over the world is fatty liver which contain alcoholic and non-alcoholic fatty liver. One-fourth among general population are impact Non-Alcoholic Fatty Liver Disease (NAFLD) in the worldwide.Retinol binding protein 4 (RBP4) is known as an adipokine, mainly synthesized and secreted from the liver and form adipose tissues. RBP4 acts as a transporter and specifically bound to retinol from liver to others tissues. Visfatin is an adipocytokine and mainly produced from visceral fat tissue, skeletal muscles as well as liver. Vitamin A absorbed, transported as retinyl esters to the liver then hydrolyzed to the retinol form and storage in hepatic stellate cells (HSCs) after reesterified with riglycerides. Hepatic retinyl esters are hydrolyzed to retinol and binds to its carrier RBP4 then transport to the target tissues. Methods: Ninety serum blood samples were collected and distributed into three groups: First group (G1) contained of (34) patients of obese NAFLD. Second group (G2) contained of (26) non obese NAFLD and control patients (G3) contained of (30) patients. Ultrasound was used to confirm the diagnosis of nonalcoholic fatty liver disease by examining the abdomen.

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Section: Resultsmentioning

confidence: 94%