Study of severe scorpion envenoming following subcutaneous venom injection into dogs: Hemodynamic and concentration/effect analysis

Elatrous, Souheil; Ouanes-Besbes, Lamia; Sik-Ali, Habiba Ben; Hamouda, Zineb; BenAbdallah, Saoussen; Tilouche, Nejla; Jalloul, Faten; Fkih-Hassen, Mohamed; Dachraoui, Fahmi; Ouanes, Islem; Abroug, Fékri

doi:10.1016/j.toxicon.2015.07.003

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…In an animal experimental research, Elatrous et al found that serum troponin increased only by the 120th min median (10 ng/ml compared to 0.2 at baseline). 12 In our study, troponin levels increased within 1 h after the sting.…”

Section: Discussionsupporting

confidence: 56%

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Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation

et al. 2017

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Section: Discussionsupporting

confidence: 56%

“…Nevertheless, cut-off predicting cardiac dysfunction in scorpion-envenomed patients is still not well studied. 12 For this reason, we conducted this study to evaluate whether troponin level elevation correlates with evidences of acute myocarditis in scorpion stung patients.…”

Section: Introductionmentioning

confidence: 99%

Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation

et al. 2017

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“…[4][5][6] The incidence of hyperglycaemia reported in severe cases of scorpion envenomation requiring ICU admission ranges from 34% to 54%. [4][5][6]10 Moreover, hyperglycaemia is more observed in children than in adult patients [4][5][6][15][16][17][18] and the use of steroids was significantly associated with hyperglycaemia on ICU admission and 24 h later. [17][18] Mechanisms of hyperglycaemia in severe scorpion envenomation Scorpion-envenoming syndrome results in a severe autonomic storm with a massive release of catecholamines, increased levels of glucagon, cortisol, thyroid hormones and either suppressed insulin levels or hyperinsulinaemia (insulin resistance).…”

Section: Incidence Of Hyperglycaemia In Severe Scorpion Envenomationmentioning

confidence: 99%

“…4 This association between hyperglycaemia and the development of organ failures was confirmed by several studies. 5,6,15,40,41 As a consequence, heart failure, neurological failure and respiratory failure are often associated with SIRS in severe scorpion envenomation, which in turn increases stress, leading to insulin resistance.…”

Section: Role Of Development Of Multiorgan Failurementioning

confidence: 99%

Incidence, mechanisms and impact outcome of hyperglycaemia in severe scorpion-envenomed patients

Bahloul

Turki

Chaari

et al. 2018

Therapeutic Advances in Endocrinology

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Hyperglycaemia is often observed in severe scorpion-envenomed patients. It is due to a severe autonomic storm with a massive release of catecholamines, increased glucagon levels, cortisol levels, and either decreased insulin levels or insulin resistance. The presence of hyperglycaemia is an indicator of severity in this specific condition. Indeed, hyperglycaemia was associated with the severity of clinical manifestations of severe scorpion envenomation requiring intensive care unit (ICU) admission. In fact, the presence of hyperglycaemia was associated with the presence of respiratory failure, pulmonary oedema, haemodynamic instability, neurological failure, multisystem organ failure, and an increased mortality and ICU length of stay. As a consequence, we think the presence of hyperglycaemia in scorpionenvenomed patients at the emergency department prompts searching for presence of systemic manifestations or cardiorespiratory manifestations. As a consequence, the presence of hyperglycaemia can help screen severe patients at the emergency department. The current management of severe scorpion envenomation involves the admission and close surveillance in the ICU, where vital signs and continuous monitoring enable early initiation of therapy for life-threatening complications. The use of antivenom for scorpion stings remains controversial. All patients with pulmonary oedema should receive prazosin and possibly dobutamine, according the scorpion's species. Mechanical ventilation is usually used in severe cases. Insulin should be reserved for severe cases with confirmed excessive hyperglycaemia (>10 mmol/l).

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“…The two topics most frequently covered are severe scorpion envenomation and acute poisoning. Various clinical and experimental studies have provided data on prevalence, benefit from specific serotherapy, acute heart failure, and the use of catecholamine [10]. In addition, various ICUs have focused on diseases related to pregnancy, *Correspondence: abidikhalid6@gmail.com 1 Medical ICU, Faculty of Medicine and Pharmacy, Ibn Sina University Hospital, Mohamed V University, Rabat, Morocco Full author information is available at the end of the article most significantly pregnancy-related acute kidney injury, and their outcome [11].…”

Section: The Current State Of Researchmentioning

confidence: 99%

Critical care research in Morocco and Tunisia

Abidi¹,

Ouanes-Besbes

2018

Intensive Care Med

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Study of severe scorpion envenoming following subcutaneous venom injection into dogs: Hemodynamic and concentration/effect analysis

Cited by 7 publications

References 36 publications

Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation

Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation

Incidence, mechanisms and impact outcome of hyperglycaemia in severe scorpion-envenomed patients

Critical care research in Morocco and Tunisia

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