Study of single-nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TAGLN) in ethnic Russians and patients with prostate cancer

Lisitskaya, K. V.; Krakhmaleva, I. N.; Shishkin, S. S.

doi:10.3103/s0891416810020060

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…In the current study, the T allele of the rs117648907 located in the intron of FMN1 was found to be correlated with an increased PanC risk. Previously published studies have found that chromosome 15q13.3 contains multiple colorectal cancer risk loci ( SCG5 rs4779584 and GREM1 rs10318) 51,52 and that FMN1 rs2306277 possibly participated in the formation of predisposition to prostate cancer 53 . Although these variants in the same loci are located in distance from and not in LD with the FMN1 rs117648907 SNP in our current study, the 15q13.3 region may harbor potential susceptibility loci involved in multiple cancers.…”

Section: Discussioncontrasting

confidence: 48%

“…Previously published studies have found that chromosome 15q13.3 contains multiple colorectal cancer risk loci (SCG5 rs4779584 and GREM1 rs10318) 51,52 and that FMN1 rs2306277 possibly participated in the formation of predisposition to prostate cancer. 53 Although these variants in the same loci are located in distance from and not in LD with the FMN1 rs117648907 SNP in our current study, the 15q13.3 region may harbor potential susceptibility loci involved in multiple cancers. More importantly, FMN1 has also been identified as a candidate gene for susceptibility to chronic pancreatitis 54 predisposing the hosts to 13.3-fold increased risk of PanC.…”

Section: Genotypementioning

confidence: 49%

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Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk

et al. 2020

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Section: Discussioncontrasting

confidence: 48%

Section: Genotypementioning

confidence: 49%

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk

et al. 2020

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“…Of the 132 human IGF–PCa studies, 89 had serum level IGF data available for meta-analysis; the remaining 43 studies were considered as supporting evidence as they did not contain any data amenable to meta-analysis [ 58 – 100 ]. One study was considered as supporting evidence since it presented data for free IGF-I in relation to PCa risk, rather than total serum levels of IGF-I [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis

Harrison

Lennon

Holly

et al. 2017

Cancer Causes Control

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PurposeTo establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3).MethodsSystematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise.ResultsOne hundred and seventy-two studies met the inclusion criteria: 31 examining the milk–IGF relationship; 132 examining the IGF–prostate cancer relationship in humans; and 10 animal studies examining the IGF–prostate cancer relationship. There was moderate evidence that circulating IGF-I and IGFBP-3 increase with milk (and dairy protein) intake (an estimated standardized effect size of 0.10 SD increase in IGF-I and 0.05 SD in IGFBP-3 per 1 SD increase in milk intake). There was moderate evidence that prostate cancer risk increased with IGF-I (Random effects meta-analysis OR per SD increase in IGF-I 1.09; 95% CI 1.03, 1.16; n = 51 studies) and decreased with IGFBP-3 (OR 0.90; 0.83, 0.98; n = 39 studies), but not with other growth factors. The IGFBP-3 -202A/C single nucleotide polymorphism was positively associated with prostate cancer (pooled OR for A/C vs. AA = 1.22; 95% CI 0.84, 1.79; OR for C/C vs. AA = 1.51; 1.03, 2.21, n = 8 studies). No strong associations were observed for IGF-II, IGFBP-1 or IGFBP-2 with either milk intake or prostate cancer risk. There was little consistency within the data extracted from the small number of animal studies. There was additional evidence to suggest that the suppression of IGF-II can reduce tumor size, and contradictory evidence with regards to the effect of IGFBP-3 suppression on tumor progression.ConclusionIGF-I is a potential mechanism underlying the observed associations between milk intake and prostate cancer risk.Electronic supplementary materialThe online version of this article (doi:10.1007/s10552-017-0883-1) contains supplementary material, which is available to authorized users.

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“…Not only have formin levels been associated with cancer prognosis, but gene variants and deletions have also been associated with the risk of cancer progression. For example, specific FMN1 variants have been linked to a higher risk of developing pancreatic [300] and prostate cancer [304]. In lung cancer, a variant in the FH2 domain of DAAM2 (p.Asp762Gly) has been associated with a protective effect, and, although not a statistically significant result, a variant in the DID (p.Arg172His) was found to be enriched in healthy controls [292].…”

Section: Formins As Prognostic Biomarkers and Therapeutical Targets In Cancermentioning

confidence: 99%

Formins in Human Disease

Labat-de-Hoz

Alonso

2021

Cells

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Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as being responsible for a human inherited disorder: a form of sensorineural hearing loss. Since then, our knowledge of the links between formins and disease has deepened considerably. Mutations of DIAPH1 and six other formin genes (DAAM2, DIAPH2, DIAPH3, FMN2, INF2 and FHOD3) have been identified as the genetic cause of a variety of inherited human disorders, including intellectual disability, renal disease, peripheral neuropathy, thrombocytopenia, primary ovarian insufficiency, hearing loss and cardiomyopathy. In addition, alterations in formin genes have been associated with a variety of pathological conditions, including developmental defects affecting the heart, nervous system and kidney, aging-related diseases, and cancer. This review summarizes the most recent discoveries about the involvement of formin alterations in monogenic disorders and other human pathological conditions, especially cancer, with which they have been associated. In vitro results and experiments in modified animal models are discussed. Finally, we outline the directions for future research in this field.

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Study of single-nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TAGLN) in ethnic Russians and patients with prostate cancer

Cited by 4 publications

References 10 publications

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk

Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis

Formins in Human Disease

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