Study of sleep microstructure in patients of migraine without aura

Nayak, Chetan S.; Sinha, Sanjib; Nagappa, Madhu; Nagaraj, Karthik; Kulkarni, Girish Baburao; Thennarasu, K; Taly, Arun B.

doi:10.1007/s11325-015-1207-x

Cited by 25 publications

(20 citation statements)

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“…73 As noted by Nayak, there is decreased cycling within REM sleep (the “micro-architecture” of sleep) in those with migraine – possibly reflecting a dysfunction of the subcortical serotoninergic system. 27 …”

Section: Does Poor Sleep Trigger Migraine Attack(s)?mentioning

confidence: 99%

“…18,20,[26][27][28][29][30] Although sleep latency does not appear to be related to migraine interictally, 20,31 important measures of sleep quality including sleep efficiency and amount of slow wave sleep are decreased in patients with migraine. [27][28][29]31 REM sleep, which has long been implicated to play a role in various headache disorders (such as cluster and hypnic headache), may also be affected in patients with migraine at baseline, with smaller studies reporting patients with migraine have a lower arousal index during REM sleep as well as lower cyclic alternating pattern at baseline. 27,32,33 Together, these findings suggest possible brainstem dysfunction in the networks important in switching between sleep stages.…”

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 99%

“…[27][28][29]31 REM sleep, which has long been implicated to play a role in various headache disorders (such as cluster and hypnic headache), may also be affected in patients with migraine at baseline, with smaller studies reporting patients with migraine have a lower arousal index during REM sleep as well as lower cyclic alternating pattern at baseline. 27,32,33 Together, these findings suggest possible brainstem dysfunction in the networks important in switching between sleep stages.…”

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 99%

“…73 As noted by Nayak, there is decreased cycling within REM sleep (the "micro-architecture" of sleep) in those with migraine -possibly reflecting a dysfunction of the subcortical serotoninergic system. 27 Furthermore, the subsequent targets of signals from the dorsal raphe nucleus are diverse, involving both cortical and subcortical regions (including the amygdala, hypothalamus, locus coeruleus, and pontine reticular formation). One of these targets, the hypothalamus, has been proposed as a central and early player in the pathophysiology of a migraine attack, as PET imaging revealed that hypothalamic activity is altered during the 24 hours prior to pain onset, with altered functional coupling with the spinal trigeminal nuclei and the dorsal rostral pons occurring soon thereafter (pre-ictally and in the early pain phase).…”

Section: Does Poor Sleep Trigger Migraine Attack(s)?mentioning

confidence: 99%

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Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

2018

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Migraine shares a complex and poorly understood relationship with sleep. Patients consistently report poor sleep prior to migraine attacks and during them, identifying poor sleep as a migraine trigger. However, anecdotally, sleep is reported to serve a therapeutic role in terminating headache. Are the associations between migraine and sleep simply the result of various bidirectional relationships? A growing body of evidence suggests there may be a common underlying etiology as well. Our objective was to review studies of sleep and migraine from the last 2 decades utilizing validated subjective and objective measures of sleep and to explore potential mechanisms underlying this complex relationship by incorporating recent advances in neuroscience. We specifically focus on insomnia, obstructive sleep apnea, parasomnias, sleep related movement disorders, and REM sleep related disorders and their relationship to migraine. Parts of brainstem-cortical networks involved in sleep physiology are unintentionally being identified as important factors in the common migraine pathway. Recent discoveries on anatomic localization (the hypothalamus as a key and early mediator in the pathophysiology of migraine), common mediating signaling molecules (such as serotonin and dopamine), and the discovery of a new CNS waste removal system, the glymphatic system, all point to a common pathophysiology manifesting in migraine and sleep problems.

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Section: Does Poor Sleep Trigger Migraine Attack(s)?mentioning

confidence: 99%

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 99%

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 99%

Section: Does Poor Sleep Trigger Migraine Attack(s)?mentioning

confidence: 99%

See 2 more Smart Citations

Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

2018

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“…По результатам исследования [15], пациенты, у которых приступы мигрени возникали преимущественно в ночные часы, отличались по целому ряду клинических признаков от пациентов, испытывающих преимущественно дневные приступы. При анализе полисомнографических характеристик пациентов с мигренью выявлялась характерная закономерность -часто возникновение приступов головных болей совпадало с фазой быстрого сна (ФБС) или с переходом от быстрого сна к медленному [16]. Наряду с этим у таких пациентов наблюдалось снижение длительности ФБС в целом и особенно в ночь, предшествующую утреннему развитию приступа мигрени.…”

Section: мигрень и инсомнияunclassified