Study of Spectral-Domain Optical Coherence Tomography in Children: Normal Values and Influence of Age, Sex, and Refractive Status

Pérez-García, Diana; Ibanez-Alperte, Juan; Remón, Laura; Cristobal, Ja; Sánchez‐Cano, Ana; Pinilla, Isabel

doi:10.5301/ejo.5000665

Cited by 22 publications

(28 citation statements)

References 31 publications

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“…In all studies reporting normative paediatric SD-OCT data of macular thickness, the thinnest area of the macula was the central area. [1][2][3][4][5][6]8 Our result was consistent with this finding. Additionally, we found that the inner circle subfield was significantly thicker than the outer circle subfield, which also was congruent with most of the previous studies.…”

Section: Macular Thicknesssupporting

confidence: 83%

“…[2][3][4][5][6] However correlation with gender has been found by some authors. For example, in Rao's study, average RNFL thickness was significantly higher in females.…”

Section: Resultsmentioning

confidence: 88%

“…10,11 In all previous SD-OCT studies that have reported RNFL thickness in children, the superior and inferior quadrants were found to be thicker than the nasal and temporal quadrants, congruent with the "double-hump" pattern. 1,[3][4][5][6]10,11,13,14 It has been reported in most studies that RNFL thickness decreases with myopia and increases with hyperopia.…”

Section: Resultsmentioning

confidence: 99%

“…15,16 However, in most paediatric studies including ours, age was not found to effect RNFL thickness. [1][2][3][4][5][6]11,14 It has been suggested in some adult studies that age-related thinning of RNFL starts later in life and the rate of loss is slower in younger ages. 17,18 This may explain the lack of an independent correlation between RNFL thickness and age among children.…”

Section: Resultsmentioning

confidence: 99%

“…However, built in normative data of SD-OCT devices are for individuals older than 18 years. To overcome this limitation, several reports have provided normal values for paediatric SD-OCT. [1][2][3][4][5][6] On the other hand, the repeatability and reproducibility of this method in children has been shown in a limited number of studies. 7,8 The purpose of this current study was to determine normal values of retinal nerve fiber layer (RNFL) and macula thickness in a cohort of healthy Caucasian children using iVue 100 SD-OCT and to assess the repeatability of the SD-OCT measurements.…”

mentioning

confidence: 99%

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Retinal Nerve Fiber Layer and Macula Thickness with Spectral Domain Optical Coherence Tomography in Children: Normal Values, Repeatability and the Inflfluence of Demographic and Ocular Parameters

Kızıloğlu¹,

Toygar²,

Toygar³

et al. 2018

Turkiye Klinikleri J Ophthalmol

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine normal values for retinal nerve fiber layer (RNFL) and macular thickness in children using spectral domain optical coherence tomography (SD-OCT), to assess the repeatability of the SD-OCT measurements and to analyse their correlations with age, gender, refraction and axial length. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Healthy children aged 5-17 years were enrolled for this cross-sectional study. All subjects underwent comprehensive ophthalmological examination, cycloplegic refraction and axial length measurement. Thereafter, three consecutive SD-OCT measurements were obtained by the same operator. The mean of three consecutive measurements for each SD-OCT parameter was included in the normal values. Repeatability was calculated by comparing the three consecutive measurements and expressed as an intraclass correlation coefficient. The correlation of all SD-OCT parameters with age, gender, spherical equivalent refraction and axial length were statistically analysed. R Re es su ul lt ts s: : Two hundred two eyes of 202 children (103 females and 99 males) with a mean age of 10.4±3.4 years were included. The mean of average RNFL thickness was 103.9±8.2 (84.3-132) µm. The mean central macular thickness was 257.4± 22.1 (217-329) µm. Intraclass correlation coefficients of repeated measurements were over 0.81 for all evaluated parameters. Males had significantly thicker central macula than females (p=0.013). On multivariate linear regression analysis, spherical equivalent refraction was the only parameter independently effective on average RNFL thickness (p<0.001). C Co on nc cl lu us si io on n: : This study has provided normal values for RNFL and macular thickness measured with SD-OCT in healthy children. The high repeatability of the measurements indicates that SD-OCT can be used reliably in children that are five years and older. Data obtained in this study may be helpful in the assessment of childhood optic nerve and macular diseases with SD-OCT. K Ke ey yw wo or rd ds s: : Child; tomography, optical coherence; macula lutea; retina Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda spektral domain optik koherens tomografi (SD-OKT) ile retina sinir lifi (RSLT) ve maküla kalınlıklarının normal değerlerini belirlemek, SD-OKT ölçümlerinin tekrarlanabilirliğini ve yaş, cinsiyet, refraksiyon ve aksiyel uzunluk ile ilişkilerini saptamak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu kesitsel çal-ışmaya yaşları 5-17 yıl arasında değişen sağlıklı çocuklar dahil edildi. Tüm olguların ayrıntılı göz muayenesi, sikloplejik refraksiyon ve aksiyel uzunluk ölçümleri yapıldı. Sonrasında art arda üç kez aynı görevli tarafından SD-OKT ölçümleri alındı. Normal değerler belirlenirken her parametre için bu üç ölçümün ortalaması alındı. Tekrarlanabilirlik ise bu üç ölçüm karşılaştırılarak hesaplandı ve sınıf içi korelasyon katsayısı olarak ifade edildi. Ayrıca tüm SD-OKT parametrelerinin yaş, cinsiyet, sferik ekivalan refraksiyon ve aksiyel uzunluk...

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Section: Macular Thicknesssupporting

confidence: 83%

“…[2][3][4][5][6] However correlation with gender has been found by some authors. For example, in Rao's study, average RNFL thickness was significantly higher in females.…”

Section: Resultsmentioning

confidence: 88%