Study of structural-functional arrangement of the adenylyl cyclase signaling mechanism of action of insulin-like growth factor 1 revealed in muscle tissue of representatives of vertebrates and invertebrates

Plesneva, S. A.; Kuznetsova, L. A.; Ao, Shpakov; Sharova, T. S.; Pertseva, M. N.

doi:10.1134/s0022093008050022

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…In fact, Willcox et al ., in a study performed on a blood‐perfused hamster cremaster muscle preparation (Willcox et al , ), reported that recombinant relaxin 2 produced a transient NO‐dependent and K + channel‐dependent vasodilation in skeletal muscle arterioles and stimulated capillaries to initiate conducted responses. This is in agreement with the suggested signalling pathway triggered by relaxin in the context of muscle tissue through receptor tyrosine kinase/Gi protein/phosphoinositide 3‐kinase/protein kinase D1/protein kinase B/NO (Plesneva et al , ).…”

Section: Effects Of Relaxin On Skeletal Musclesupporting

confidence: 91%

Relaxin and insulin‐like peptide 3 in the musculoskeletal system: from bench to bedside

Ferlin

Toni

Sandri

et al. 2016

British J Pharmacology

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Section: Effects Of Relaxin On Skeletal Musclesupporting

confidence: 91%

Relaxin and insulin‐like peptide 3 in the musculoskeletal system: from bench to bedside

Ferlin

Toni

Sandri

et al. 2016

British J Pharmacology

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“…As previously mentioned, in the same experimental model these authors showed also a stimulating effect of insulin on AC activity, and suggested that this effect is produced through a signaling system involving both Gs and Gi proteins (Plesneva et al, 2001). Similar results were also obtained with relaxin (Shpakov et al, 2004) and insulin-like growth factor 1 (Plesneva et al, 2008), both peptides belonging to the insulin superfamily, with the only difference that in the latter case, PKC is not the PKCz isoform but another isoform close to the PKCe of the vertebrate brain.…”

Section: Membrane Receptor Agonists and The Ac/camp Systemsupporting

confidence: 78%

Cyclic AMP signaling in bivalve molluscs: an overview

Fabbri¹,

Capuzzo²

2010

J. Exp. Zool.

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The cyclic AMP (cAMP)-dependent signaling accounts for the control of cellular cascades involved in many physiological functions, and a wealth of information is available on the cAMP system that operates in mammalian cells. Nevertheless, cAMP has a central role also in nonmammalian vertebrates and invertebrates. The present review aims at examining the information available on bivalve molluscs, from the first studies carried out in the early 1980s to the last progresses made in the present days. The major focus is on the structural and operational characteristics of the main actors of the signaling pathway, i.e., adenylyl cyclase, G proteins, and protein kinase A, and on the role played by the cyclic nucleotide on smooth muscle, heart, gills, gonads, and metabolism regulation. Moreover, recent evidence regarding the cAMP system as a target of environmental stress factors are discussed. It will become clear that cAMP does play a wide and important role in bivalve physiology. Several issues have been sufficiently clarified, although investigated only in a few model species. However, further fundamental aspects remain unknown, mainly regarding molecular features and interactions with other signaling pathways, thus requiring further elucidation. J. Exp. The discovery of cyclic AMP (cAMP) about 50 years ago was the crucial event leading to our current paradigm of second-messenger signaling, through which many hormones, neurotransmitters, odorants, and autocrine/paracrine regulators modulate physiological functions. Other second messengers were discovered from then on; however, cAMP has never left its center stage. Biological and genetic evidence point to roles for cAMP in a vast array of biological systems, including oogenesis and embryogenesis, development, hormone secretion, olfaction, cardiac contraction, smooth muscle relaxation, metabolism, etc. Therefore, understanding the cAMP-dependent pathway in all its parts became a scientific priority that prompted to a remarkable amount of studies and relevant achievements (Diel et al., 2008;Sadana and Dessauer, 2009). Admittedly, the pathway once considered simple and straightforward became very complex, thus requiring more and more sophisticated investigations mainly focused on mammalian cells. If this is easily understandable also for the implications of cAMP signaling in human health and possible therapeutic applications, the counterpart is a rather scarce knowledge of the system in nonmammalian vertebrates and invertebrates.The present review focuses on the cAMP-dependent pathway in bivalve molluscs, aimed at collecting and ordering the research outputs produced in this regard. Bivalve molluscs are the model animals currently studied in our laboratories, and we did experience such fragmented information. Moreover, growing interest is addressed to these animals as widely cultivated aquaculture species and sentinel organisms used for evaluating the environmental quality. Undoubtedly cAMP plays a role in these contexts and an organized set of information would be of be...

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“…Relaxin activates the AC signaling pathway in skeletal muscles through the following signal chain: relaxin receptor tyrosine kinase → Gi protein (βγ‐dimer) → phosphatidylinositol 3‐kinase (PI3K) → protein kinase Cz (PKCζ) → heterotrimeric Gs protein → AC → protein kinase A (Kuznetsova et al., ; Shpakov et al., , , b, , ; Pertseva et al., ; Plesneva et al., ). Relaxin also activates the NO pathway in skeletal muscle via relaxin‐mediated activation of receptor tyrosine kinase → Gi protein → PI3K → protein kinase D1 → protein kinase B → NO (Plesneva et al., ). NO regulates various biological processes, and is produced by NO synthase (Stamler & Meissner, ).…”

Section: Musclementioning

confidence: 99%

The effect of relaxin on the musculoskeletal system

Dehghan

Haerian

Muniandy

et al. 2013

Scandinavian Med Sci Sports

120

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Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.

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Study of structural-functional arrangement of the adenylyl cyclase signaling mechanism of action of insulin-like growth factor 1 revealed in muscle tissue of representatives of vertebrates and invertebrates

Cited by 4 publications

References 19 publications

Relaxin and insulin‐like peptide 3 in the musculoskeletal system: from bench to bedside

Relaxin and insulin‐like peptide 3 in the musculoskeletal system: from bench to bedside

Cyclic AMP signaling in bivalve molluscs: an overview

The effect of relaxin on the musculoskeletal system

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