Study of surfactant level in cases of primary atrophic rhinitis

Sayed, Ramy K. A.; Abou-Elhamd, Kamal-Eldin Ahmed; Abdel‐Kader, Mahmoud H.; Saleem, Tahia Hashem

doi:10.1258/0022215001905508

Cited by 26 publications

(29 citation statements)

References 24 publications

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“…Ein anderer Erklä-rungsansatz nimmt an, dass Allergene von den Liposomen eingeschlossen und somit inaktiviert werden können [1,5]. Zu berück-sichtigen ist ferner, dass Liposomen hauptsächlich aus Phosphatidylcholin bestehen, einem Bestandteil, der bei gesunden Menschen 75,35% der Phospholipide des natürlichen nasalen Surfactant ausmacht [19].…”

Section: Abbildung 1a Phosphatidylcholin 24unclassified

Behandlung der saisonalen allergischen Rhinokonjunktivitis mit einem liposomalen Nasenspray

Weston¹,

Mösges²

2010

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Section: Abbildung 1a Phosphatidylcholin 24unclassified

Behandlung der saisonalen allergischen Rhinokonjunktivitis mit einem liposomalen Nasenspray

Weston¹,

Mösges²

2010

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“…1 Numerous theories have been proposed to account for the pathogenesis of this condition. 1,2 Although fungal rhinosinusitis has gained much attention in recent years, the role of fungi in the pathogenesis of primary atrophic rhinitis is scarcely documented in the literature. A search of the PubMed/Medline database failed to identify fungal studies in this condition in humans.…”

Section: Introductionmentioning

confidence: 99%

Microbiological study of role of fungi in primary atrophic rhinitis

Effat

Madany

2008

J. Laryngol. Otol.

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Background: Fungal rhinosinusitis has gained much attention in recent years. To our knowledge, no previous studies have addressed the role of fungus in primary atrophic rhinitis.Study design: Prospective case study. Patients and methods: All cases of primary atrophic rhinitis presenting to the out-patient department at El-Sahel Teaching Hospital over a five-month period were included in the study. Crusts and purulent secretions removed from patients' nasal cavities underwent microbiological analysis at the Medical Microbiology and Immunology department of the Cairo University Faculty of Medicine. Special emphasis was placed on fungal isolation.Results: Fourteen consecutive cases of primary atrophic rhinitis were studied in the five-month period starting 26 November 2007. Patients comprised eight females and six males, with an age range of 12 to 65 years (mean 37 years). Microscopy of the crusts and purulent secretions showed pus cells in most of the samples. Klebsiella species were isolated from nine patients (65 per cent), and other bacterial species were isolated in most of the remainder. Fungal elements, most commonly aspergillus species, were isolated in 13 patients (93 per cent).Conclusion: It is proposed that the initial trigger for primary atrophic rhinitis is a virulent bacterial infection of the nasal lining, which leads to damage of the ciliated epithelium. This initiates the cascade of events leading to inflammation of the mucosa and submucosa, with secondary pyogenic osteomyelitis of the turbinate bone. The persistence of purulent secretion, within the setting of impaired mucociliary clearance, leads to saprophytic fungal colonisation which contributes greatly to the clinical picture.

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“…Ultrastructural studies have identifi ed lamellar bodies in the gastrointestinal tract, oral cavity, lateral nasal wall, mucosal cells of the stomach, and in mesodermal cells in sliding membranes such as the peritoneum, pericardium, and mesothelium [2] . Although there are few studies demonstrating surfactant in the upper airways, decreased levels of the various phospholipid components of surfactant have been implicated as playing a role in atrophic rhinitis [3] . Additionally, surfactant has been identifi ed in the porcine Eustachian tube and may contribute to lowering the opening pressure between the nasopharynx and middle ear [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Presence of Surfactant Lamellar Bodies in Normal and Diseased Sinus Mucosa

Woodworth¹,

Smythe²,

Spicer

et al. 2005

ORL

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Background:Pulmonary surfactant originates from phospholipid lamellar bodies secreted from the type II epithelial cell of the alveolus. In the lower airway, surfactant optimizes surface tension and oxygen exchange, decreases mucus viscosity and aids in mechanical elimination of inhaled pathogens. In addition to the lung, lamellar bodies have been identified in many other cell types throughout the human body. However, no prior studies have identified lamellar bodies in human sinus mucosa. Objectives: We performed ultrastructural studies to assess whether lamellar bodies are present in the human sinus in a variety of diseased and normal epithelium. Methods:We biopsied sinus mucosa from 5 subjects, 1 each with allergic fungal sinusitis, eosinophilic mucin rhinosinusitis, cystic fibrosis, frontal sinus mucocele, and cerebrospinal fluid leak (healthy control). Mouse lung served as a positive control. Specimens were prepared using ferrocyanide-reduced osmium tetroxide and thiocarbohydrazide for fixation (R-OTO method) to avoid extraction of phospholipids during dehydration and were viewed with transmission electron microscopy. Results:We identified lamellar bodies in the sinus mucosa of all patients. Additionally, preservation of mouse lung lamellar bodies confirms that the R-OTO method is a valid technique to preserve these structures. Conclusions:We describe a simpler, faster technique for identification of cellular phospholipid components than those used previously. Definitive identification of these lamellar bodies within ciliated pseudostratified epithelium of the upper airway indicates that surfactant may have a role in sinus function and pathophysiology.

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Study of surfactant level in cases of primary atrophic rhinitis

Cited by 26 publications

References 24 publications

Behandlung der saisonalen allergischen Rhinokonjunktivitis mit einem liposomalen Nasenspray

Behandlung der saisonalen allergischen Rhinokonjunktivitis mit einem liposomalen Nasenspray

Microbiological study of role of fungi in primary atrophic rhinitis

Presence of Surfactant Lamellar Bodies in Normal and Diseased Sinus Mucosa

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