Study of synthesis and analysis of bio-inspired polymers-review

Kalidas, Vinoth Kumar; Pavendhan, R; Sudhakar, K.; Sumanth, T P; Ram, A Sharvesh; Kumar, Sriram; Kumar, K. Yeswanth

doi:10.1016/j.matpr.2020.12.831

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…In the frame of the bio-circular economy [1,2], the replacement of petroleum-based plastics with eco-friendly biodegradable polymers such as polylactides (PLAs), polyalkanoates (PHAs), poly(ε-caprolactone) (PCL), and others, as well as the assessment of their decomposition mechanisms and exploitation lifetimes [3], are the key challenges in environmental management, packaging, and biomedicine. As is well-known, PLA is a linear aliphatic polyester produced from the L and D isomers of lactic acid formed during the fermentation of the natural raw materials [4,5]. Polylactides' family, as the main commercial product on the market comprising biodegradable materials, is broadly implemented in many areas such as food packaging, eco-friendly materials design, drug delivery vehicles exploitation, and others [6,7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Modeling of Polylactide Photodegradation under Ultraviolet Irradiation: Bio-Based Polyester Photolysis Mechanism

Lomakin,

Mikheev,

Usachev

et al. 2024

Polymers

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In our study, we investigated the accelerated aging process of PLA under 253.7 nm UV-C irradiation with the use of the GPC, NMR, FTIR, and DSC methods and formal kinetic analysis. The results of GPC and DSC indicated a significant degree of destructive changes in the PLA macromolecules, while spectroscopic methods NMR and FTIR showed maintenance of the PLA main structural elements even after a long time of UV exposure. In addition to that, the GPC method displayed the formation of a high molecular weight fraction starting from 24 h of irradiation, and an increase in its content after 144 h of irradiation. It has been shown for the first time that a distinctive feature of prolonged UV exposure is the occurrence of intra- and intermolecular radical recombination reactions, leading to the formation of a high molecular weight fraction of PLA decomposition products. This causes the observed slowdown of the photolysis process. It was concluded that photolysis of PLA is a complex physicochemical process, the mechanism of which depends on morphological changes in the solid phase of the polymer under UV radiation.

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Section: Introductionmentioning

confidence: 99%

Evaluation and Modeling of Polylactide Photodegradation under Ultraviolet Irradiation: Bio-Based Polyester Photolysis Mechanism

Lomakin,

Mikheev,

Usachev

et al. 2024

Polymers

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“…Monomers derived from renewable biomass sources, such as vegetable oils, are mostly considered for developing green and sustainable polymers. They are abundantly available in nature with diverse structural features and are usually cheap as well as mostly non-toxic [4,5]. As one of the most promising vegetable oils, castor oil has been extensively used to develop partially and fully bio-based sustainable polymers, including polyurethanes, polyesters, and polyamides [6,7].…”

Section: Introductionmentioning

confidence: 99%

High Concentration Lignin Biocomposites with Low Melting Point Biopolyamide

Baniasadi,

Lipponen,

Asplund

et al. 2022

SSRN Journal

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“…Although these polymers are biocompatible, the high rate of biodegradation of some natural polymers during enzymatic, oxidative, and hydrolytic processes in the body significantly reduces the lifetime of delivery systems [ 12 ]. Another way to increase the biocompatibility of polymer systems in vivo is the application of synthetic bio-inspired macromolecules [ 13 ]. They can be fully biodegradable, such as poly(lactic acid) [ 14 ] or poly(L-amino acids) [ 8 ], or possess non-biodegradable carbon–carbon backbone bearing cleavable bio-inspired side units, such as saccharide fragments [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Nanoparticles Based on Block-Copolymers of Poly(2-Deoxy-2-methacrylamido-d-glucose)/Poly(N-Vinyl Succinamic Acid) with Poly(O-Cholesteryl Methacrylate) for Delivery of Hydrophobic Drugs

Levit

Vdovchenko

Dzhuzha

et al. 2021

IJMS

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The self-assembly of amphiphilic block-copolymers is a convenient way to obtain soft nanomaterials of different morphology and scale. In turn, the use of a biomimetic approach makes it possible to synthesize polymers with fragments similar to natural macromolecules but more resistant to biodegradation. In this study, we synthesized the novel bio-inspired amphiphilic block-copolymers consisting of poly(N-methacrylamido-d-glucose) or poly(N-vinyl succinamic acid) as a hydrophilic fragment and poly(O-cholesteryl methacrylate) as a hydrophobic fragment. Block-copolymers were synthesized by radical addition–fragmentation chain-transfer (RAFT) polymerization using dithiobenzoate or trithiocarbonate chain-transfer agent depending on the first monomer, further forming the hydrophilic block. Both homopolymers and copolymers were characterized by 1H NMR and Fourier transform infrared spectroscopy, as well as thermogravimetric analysis. The obtained copolymers had low dispersity (1.05–1.37) and molecular weights in the range of ~13,000–32,000. The amphiphilic copolymers demonstrated enhanced thermal stability in comparison with hydrophilic precursors. According to dynamic light scattering and nanoparticle tracking analysis, the obtained amphiphilic copolymers were able to self-assemble in aqueous media into nanoparticles with a hydrodynamic diameter of approximately 200 nm. An investigation of nanoparticles by transmission electron microscopy revealed their spherical shape. The obtained nanoparticles did not demonstrate cytotoxicity against human embryonic kidney (HEK293) and bronchial epithelial (BEAS-2B) cells, and they were characterized by a low uptake by macrophages in vitro. Paclitaxel loaded into the developed polymer nanoparticles retained biological activity against lung adenocarcinoma epithelial cells (A549).

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Study of synthesis and analysis of bio-inspired polymers-review

Cited by 8 publications

References 13 publications

Evaluation and Modeling of Polylactide Photodegradation under Ultraviolet Irradiation: Bio-Based Polyester Photolysis Mechanism

Evaluation and Modeling of Polylactide Photodegradation under Ultraviolet Irradiation: Bio-Based Polyester Photolysis Mechanism

High Concentration Lignin Biocomposites with Low Melting Point Biopolyamide

Self-Assembled Nanoparticles Based on Block-Copolymers of Poly(2-Deoxy-2-methacrylamido-d-glucose)/Poly(N-Vinyl Succinamic Acid) with Poly(O-Cholesteryl Methacrylate) for Delivery of Hydrophobic Drugs

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