Study of the antidepressant properties of some plants

Fedorova, Yu. S.; Kulpin, P. V.; Kotova, Tatyana; Денисова, С.В.; Beregovykh, G. V.

doi:10.1063/5.0069670

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…To our knowledge, there is a significant lack of studies on this Hedysarum species, including its neurological bioactivity. Previous report indicated that the ethanolic extract of HA exerts antidepressant and antipsychotic-like action in behavioral tests [16,17]. In this study, the extract of HA in a dose of 50 mg/kg significantly increased the amount of time spent in the open arms and the number of entries into the open arms compared to the control group (p < 0.05) indicating the presence of anxiolytic activity of extract.…”

Section: Discussionsupporting

confidence: 56%

Ethanolic Extract of Hedysarum Alpinum L Is Rich in Flavonoids and Shows Free Radical Scavenging and Psychological Modulation Activities

Jalsrai¹,

Urtnasan²,

Hsieh-Li³

2023

J. Food Eng. Tech.

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Hedysarum alpinum L (HA) is reported to be able to support the immune and nervous systems. However, there is only a few reports about the pharmacological activity of this plant. In current study, we investigated the phytochemical and pharmacological properties of an extract of HA using in vitro and iv vivo models. An extract of the specimens preserved in 70% ethanol was filtered and vacuum dried. Established conventional methods were used for quantitative determination of total phenolic and flavonoids content. Phytochemical characterization showed gallic acid, rutin, and quercetin are rich in the ethanolic extract of HA. In addition, the extract showed free radical scavenging activity on hydroxyl and lipid radicals with IC50 6.72 and 7.73 mg/ml, respectively. Furthermore, in vivo studies were performed on rats with orally applying the HA extract and then assessed their psychological behaviors in elevated plus maze (EPM) and open-field tasks. The HA extract exhibited psychological modulation activity. Our study suggests the ethanolic extract of HA could be potential to be used in the products of mood soother.

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Section: Discussionsupporting

confidence: 56%

Ethanolic Extract of Hedysarum Alpinum L Is Rich in Flavonoids and Shows Free Radical Scavenging and Psychological Modulation Activities

Jalsrai¹,

Urtnasan²,

Hsieh-Li³

2023

J. Food Eng. Tech.

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“…Roots, H. alpinum L. herbs showed a pronounced anti-anxiety effect of the medicinal plant extracts and a complete absence of a depressive effect. This substantiates the possibility of using these drugs for the prevention and correction of mental disorders associated with aggression, increased levels of anxiety, and cognitive disorders (Fedorova et al, 2021).…”

Section: Introductionsupporting

confidence: 60%

Comparison of Anatomical Characteristics and Phytochemical Components Between Two Species of Hedysarum (Fabaceae)

Kusmangazinov,

Kurmanbayeva,

Zharkova

et al. 2023

OnLine Journal of Biological Sciences

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Hedysarum L. is one of the large genus of the Fabaceae Lindl. family, consisting of 200 species. Species in the genus Hedysarum are valuable forage and medicinal resources. In this study, we studied Hedysarum theinum Krasnob and Hedysarum neglectum Ledeb growing in the western Altai of Eastern Kazakhstan. H. theinum is a perennial, herbaceous, valuable medicinal plant, a rare species, an Altai-Dzungarian endemic, and a globally endangered species. H. neglectum is a perennial plant of high medicinal and fodder value, growing mainly in the sub-alpine zone. The purpose of the work is to identify the anatomical features and determine the phytochemical composition of the components of two species of Hedysarum. Route-reconnoitering methods were used in a field search of two species of Hedysarum for comparative study in 2020-2021. The extracts were analyzed by gas chromatography with mass spectrometric detection. The location of biologically active substances in the anatomical structure of the stem has been established. Biologically active substances are concentrated around the conductive bundles of the leaf and stem. The comparative anatomical structure of the stem in H. theinum revealed a thick ring of sclerenchyma under the cambium, which is absent in H. neglectum. In determining the phytochemical compounds of the aboveground organs of two Hedysarum species, the total number of components was 74, of which 55 compounds were found in H. theinum and 57 in H. neglectum. In both species, 37 components were detected, in H. neglectum 11 components had significant content, in H. theinum 9 components contained a significant percentage of compounds. Analysis of the root extract showed that H. theinum contains 27 and H. neglectum contains 29 compounds. Of these, 15 compounds are characteristic of both species. The phytochemical data obtained confirm the anti-inflammatory, antibacterial, antifungal, antimicrobial, antimalarial, and antitumor properties of these plants.

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Study of the antidepressant properties of some plants

Cited by 2 publications

References 9 publications

Ethanolic Extract of Hedysarum Alpinum L Is Rich in Flavonoids and Shows Free Radical Scavenging and Psychological Modulation Activities

Ethanolic Extract of Hedysarum Alpinum L Is Rich in Flavonoids and Shows Free Radical Scavenging and Psychological Modulation Activities

Comparison of Anatomical Characteristics and Phytochemical Components Between Two Species of Hedysarum (Fabaceae)

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