Study of the Antifungal Activity of Shikonin and Alcoholic – Oily Extracts of Iranian Arnebia euchroma L

Sabokbar, A; Tabaraie, Bahman; Karimi, Mehdi Zand; Talebi, Somayeh

doi:10.15171/ijbsm.2017.20

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Doulah et al [63] confirmed that A. fimbriopetala, A. linearifolia, A. garandiflora, and A. tubata species growing wild in Iran have a slightly significant effect on fungi. Other study, [64] also showed that the MIC and MFC values of commercially purchased shikonin had a 30% greater effect on fungi [dermatophytic fungal strains; Trichophyton mentagrophytes (PTCC5054), Trichophyton rubrum (PTCC5143), Microsporum canis (PTCC5069), and C. albicans (PTCC5027), saprophytic strains; Aspergillus fumigatus (PTCC5009) and Penicillium chrysogenum (PTCC5076)] than the alcoholic extraction of the root. Shen et al [65] reported that the A. euchroma extract had little effect on fungi strain.…”

Section: Discussionmentioning

confidence: 93%

Phytochemical Screening, Antimicrobial, Antipellicle and Antibiofilm Activities of the Root of Alpine Medicinal Plant (<i>Arnebia euchroma</i> (Royle) I.M.Johnst.)

Ullah,

Hassan,

Khan

et al. 2023

Pol. J. Environ. Stud.

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This study aims to analyze the phytochemical and antimicrobial-related assays including antibacterial, antifungal, antipellicle, and antibiofilm potential of the root of an alpine medicinal plant (Arnebia euchroma (Royle) I.M.Johnst). Ethanolic, methyl acetate, chloroform, and aqueous extracts of root parts of the A. euchroma plant were prepared. The active metabolites of the root part of the plant were evaluated both qualitatively and quantitatively by GC-MS and HPLC techniques, using ethanolic extract. The antimicrobial potential of A. euchroma was investigated using crude extract, fractions, and AgNPs of the A. euchroma root against two Gram-positive bacteria (Enterococcus, Staphylococcus aureus) four Gram-negative bacteria (Salmonella typhi, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris) and five fungal strains (Rhizoctonia, Cuneate fasciculus, Aspergillus niger, Fusarium oxysporum, and Candida auris). All the bacterial strains showed sensitivity toward all the fractions

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Section: Discussionmentioning

confidence: 93%

Phytochemical Screening, Antimicrobial, Antipellicle and Antibiofilm Activities of the Root of Alpine Medicinal Plant (<i>Arnebia euchroma</i> (Royle) I.M.Johnst.)

Ullah,

Hassan,

Khan

et al. 2023

Pol. J. Environ. Stud.

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“… Shishodia & Shankar, 2020 SC5314, SN250 strains Shifting mitochondrial aerobic respiration and promoting endogenous reactive oxygen species augmentation thereby causing DNA damage. Liao et al, 2016 Agrobacterium rhizogenes 15834 − Boehm, Sommer, Li, & Heide, 2000 S. aureus ATCC 33591 (MRSA) and S. aureus ATCC 25923 (MSSA) − Lee et al, 2015 Iranian Arnebia euchroma extract Trichophyton mentagrophytes (PTCC5054), Microsporum canis (PTCC5069), Trichophyton rubrum (PTCC5143), Candida albicans (PTCC5027), Aspergillus fumigatus (PTCC5009) and Penicillium chrysogenum (PTCC5076) − Sabokbar, Tabaraie, Karimi, & Talebi, 2017 Lithospermum erythrorhizon seeds Bacillus subtilis 613R, Clavibacter michigenensis subsp. nebraskensis CN74-1, Agrobacterium radiobacter K84, Agrobacterium tumefaciens C58, Escherichia coli ESS, Erwinia carotovora ATCC 15713, Pseudomonas aureofaciens , Pseudomonas fluorescens , Pseudomonas syringae B, Ralstonia solanacearum , and Serratia marsecens − Brigham, Michaels, & Flores, 1999 Acetylshikoninshikonin, β -sitosterol, β,β -dimethylacryl shikonin and deoxyshikonin from L. erythrorhizon Porphyromonas gingivalis (ATCC 33277), Streptococcus mutans (UA 159), Fusobacterium nucleatum (ATCC 25586) and Lactobacillus acidophilus (ATCC 4356) − Li, Xu, Zhu, & Wang, 2012 β,β -dimethyl acrylshikonin, isovaleryl shikonin, β -hydroxyiso valerylshikonin and shikonin isovalerate from Arnebia hispidissima (Lehm.)…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022

Kaur

Sharma

Singh

et al. 2022

Chinese Herbal Medicines

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Therapeutic effects of medicinal plants in vulvovaginal candidiasis: a review on randomized clinical trials

Bhat,

Nagaraj,

Poojar

et al. 2024

Reviews and Research in Medical Microbiology

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Introduction: Vulvovaginal candidiasis (VVC), characterized by cheesy vaginal discharge, pain during sexual intercourse and itching is the fungal infection of female genital tract. Candida albicans is the common causative agent for this condition followed by many non-albicans Candida species. Due to the greater concern of drug resistance in Candida species, many alternative therapeutic methods have been proposed, including the use of various plant extracts. The alternate methods are effective in treating the symptomatic cases by reducing the clinical symptoms and Candida load. The objective of this review is to explore the therapeutic effectiveness of various plant extracts in vulvovaginal candidiasis. Materials and methods: A literature survey was performed in PubMed, Web of Science, Scopus and Google Scholar to find relevant clinical trials on vulvovaginal candidiasis. After the removal of duplicates, a total of 21 clinical trials were considered to evaluate the anti-Candida activity of medicinal plant products against vulvovaginal candidiasis. Results: The results of the clinical trials show that, the extracts from Curcuma longa, Zingiber officinale, Allium sativum, Zataria multiflora and Lawsonia inermis have showed potent anti-Candida activity and many other plant products were found to be as effective as the conventional drugs used. Conclusion: Due to the limited number of clinical trials available, it is difficult to come to a conclusion regarding the clinical effectiveness of various plant extracts in the effective treatment of vulvovaginal candidiasis. So, more research is needed to evaluate the effectiveness of each of these plant extracts as therapeutic alternatives to treat this condition.

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Study of the Antifungal Activity of Shikonin and Alcoholic – Oily Extracts of Iranian Arnebia euchroma L

Cited by 3 publications

References 9 publications

Phytochemical Screening, Antimicrobial, Antipellicle and Antibiofilm Activities of the Root of Alpine Medicinal Plant (<i>Arnebia euchroma</i> (Royle) I.M.Johnst.)

Phytochemical Screening, Antimicrobial, Antipellicle and Antibiofilm Activities of the Root of Alpine Medicinal Plant (<i>Arnebia euchroma</i> (Royle) I.M.Johnst.)

Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022

Therapeutic effects of medicinal plants in vulvovaginal candidiasis: a review on randomized clinical trials

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