Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

Shaheli, Marjan; Yaghobi, Ramin; Rezaeian, Abbas Ali; Saadi, Mahdiyar Iravani; Ramzi, Mani

doi:10.5812/jjm.8(4)2015.18212

Cited by 3 publications

(3 citation statements)

References 55 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with studies of leukemia patients reported from Korea, Iraq and Iran [ 40 – 42 ] as well as consistent with prevalence studies in Ethiopia of HBsAg [ 28 , 30 , 33 ]. HBV DNA has been detected in peripheral blood, even when levels of HBsAg or anti-HBcAg are undetectable.…”

Section: Discussionsupporting

confidence: 92%

“…A possible explanation underlying occult HBV infection in this leukemia cohort may be related to the use of transfusions of blood and/or blood products, known to transmit HBV infection [ 40 , 42 ]. Although the majority of patients in our study had been transfused with blood products, we did not find a statistically significant association between either total or occult HBV infection and previous transfusion history (P > 0.05), a finding in line with other reports of HBV positivity [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study

Alemu,

Gumi,

Tsegaye

et al. 2023

Infect Agents Cancer

View full text Add to dashboard Cite

Background Leukemic patients are prone to infectious agents such as viruses due to dysregulated immune system resulting from infiltration of the bone marrow by malignant cells, chronic stimulation, reactivation of some viruses and viral pathogenicity as well as rarely from acquisition of a new infections leading to severe complications. However, the prevalence of these infections has not been systematically documented in resource-limited settings such as Ethiopia. Objective To determine the prevalence of HBV, HCV, and HIV among adult and adolescent in-patients with acute leukemia before the administration of chemotherapy, at the Tikur Anbessa Specialized Hospital (TASH) in Addis Ababa, Ethiopia. Methods A cross sectional study was conducted on 176 adult and adolescent inpatient Ethiopians, who were diagnosed with acute leukemia from April 2019 to June 2021. Socio-demographic characteristics and relevant clinical data were collected. Peripheral blood samples were collected and tested for HBV, HIV, and HCV using Enzyme-Linked Immunosorbent Assay (ELISA) and real-time PCR. Chi-square tests were used to assess associations between variables. Results Of the 176 patients, 109(62%) were males. The median age was 25[IQR,18–35] yr, with a range from 13 to 76 year. The prevalence of HBV (positivity for HBsAg plus HBV DNA), HCV and HIV was 21.6%, 1.7%, and 1.7%, respectively. HBsAg was positive in 19 cases (10.8%). Among 157 HBsAg negative patients, 52(33.1%) were positive for Anti-HBcAg; of these seropositive cases, 47.5% were positive for HBV DNA. Most DNA positive, HBsAg negative cases (79.0%) had DNA concentrations below 200 IU/ml indicating true occult HBV infection (OBI). Of the 176 cases, 122 had a history of blood transfusions, but no statistically significant association was found between HBV infection and blood product transfusion history (P = 0.963). Conclusions The prevalence of HBV, HIV and HCV in patients with acute leukemia was similar to the national prevalence level of these infections. Given the HBsAg positivity and the high prevalence of occult hepatitis B infection in our study, these patients may be at increased risk for chemotherapy related hepatitis flares. Hence, clinicians caring these patients are strongly advised to screen their patients for HBV and also for HIV and HCV infections routinely.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study

Alemu,

Gumi,

Tsegaye

et al. 2023

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…Briefly, the TTV genomic DNA was extracted from blood using dinitrophenol (DNP) kit (Cinna Gen Inc., Tehran, Iran) according to manufacturer's instructions. The presence of TTV genomic DNA was analyzed in HSCT patients using an in-house semi nested-PCR protocol, as previously described (Shaheli M et al, 2015).…”

Section: Methodsmentioning

confidence: 99%

Genetic variation of TNF-α and IL-10, IL-12, IL-17 genes and association with torque teno virus infection post hematopoietic stem cell transplantation

Ramzi¹,

Arandi²,

Tahereh³

et al. 2019

View full text Add to dashboard Cite

Little is known about the role of genetic variation in the genes for cytokines and susceptibility to viral infection especially torque teno virus (TTV) following allogeneic hematopoietic stem cell transplantation. In this study, the association between interleukin-12, interleukin-17, interleukin-10 (IL-12,-17,-10) and tumor necrosis factor α (TNF-α) polymorphisms was evaluated in patients with TTV infection who underwent allogeneic hematopoietic stem cell transplantation from South of Iran. The single nucleotide polymorphisms in the cytokine genes including IL-12 (-1188A/C), IL-17 (-197G/A), IL-10 (-1082G/A,-819C/T and-592C/A) and TNF-α (-308 G/A) were analyzed by PCR-RFLP methods. While our results did not show any association between IL-17, IL-12 and IL-10 (-819C/T and-1082G/A) polymorphisms and TTV infection status, heterozygote genotype of IL-10 (-592C/A) had direct correlation with TTV infection and A allele of TNF-α (-308G/A) showed a protective effect against TTV infection (P = 0.05 and P = 0.025, respectively). Within the group of patients who experienced acute graft-versus-host disease, the AA genotype and the A allele of IL-17 (-197 G/A) were significantly higher in non-infected patients compared to infected ones (p = 0.024 and p = 0.057, respectively). It was also observed that among infected patients, the GG genotype of IL-17 and AA genotype of TNF-α were significantly increased in hematopoietic stem cell transplanted patients with low grade (grade I+II) acute graftversus-host disease compared to high grade (grade III and IV) disease (p = 0.056 and p = 0.056, respectively). Taken together, genetic variation of IL-10 (-592C/A) and TNF-α (-308G/A) genes might be associated with susceptibility to TTV infection post hematopoietic stem cell transplantation.

show abstract

The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses

Mahmud

Akbarzadeh

Abu‐Raddad

2018

Sci Rep

104

112

View full text Add to dashboard Cite

The aim of this study was to characterize hepatitis C virus (HCV) epidemiology in Iran and estimate the pooled mean HCV antibody prevalence in different risk populations. We systematically reviewed and synthesized reports of HCV incidence and/or prevalence, as informed by the Cochrane Collaboration Handbook, and reported our findings following the PRISMA guidelines. DerSimonian-Laird random effects meta-analyses were implemented to estimate HCV prevalence in various risk populations. We identified five HCV incidence and 472 HCV prevalence measures. Our meta-analyses estimated HCV prevalence at 0.3% among the general population, 6.2% among intermediate risk populations, 32.1% among high risk populations, and 4.6% among special clinical populations. Our meta-analyses for subpopulations estimated HCV prevalence at 52.2% among people who inject drugs (PWID), 20.0% among populations at high risk of healthcare-related exposures, and 7.5% among populations with liver-related conditions. Genotype 1 was the most frequent circulating strain at 58.2%, followed by genotype 3 at 39.0%. HCV prevalence in the general population was lower than that found in other Middle East and North Africa countries and globally. However, HCV prevalence was high in PWID and populations at high risk of healthcare-related exposures. Ongoing transmission appears to be driven by drug injection and specific healthcare procedures.

show abstract

Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

Cited by 3 publications

References 55 publications

Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study

Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study

Genetic variation of TNF-α and IL-10, IL-12, IL-17 genes and association with torque teno virus infection post hematopoietic stem cell transplantation

The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses

Contact Info

Product

Resources

About