Study of the birthweight of parents experiencing unexplained recurrent miscarriages

Placebo‐controlled trial of active immunization with third party leukocytes in recurrent miscarriage

“…A close relationship between low birthweight and RM has been reported previously (23,24). The significantly higher median birthweight in the actively immunized patients with primary RM (Table IV) could be a consequence of an improved placental function after immunization.…”

Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients

“…On average, women with RM give birth to children with lower than normal birth weight [25] and girls born with low birth weight seem in their adult life to exhibit an increased risk of RM [30]. Low birth weight and RM thus seem to be conditions with overlapping causal factors and we therefore investigated whether the G14bp ins could be one of the genetic factors associated with both conditions.…”

Families with a perinatal death: is there an association between the loss and the birthweight of surviving siblings?

“…Several studies have investigated birth outcome for women who have experienced fetal losses, most commonly spontaneous abortions. Women who experience habitual abortions (at least three consecutive miscarriages) seem to give birth to liveborn infants with lower birthweight than average, 10,21–23 showing an association between recurrent miscarriage and low birthweight 22,23 9,10,24,25 but not all 8,26–28 .…”

“…Several studies have investigated birth outcome for women who have experienced fetal losses, most commonly spontaneous abortions. Women who experience habitual abortions (at least three consecutive miscarriages) seem to give birth to liveborn infants with lower birthweight than average, 10,[21][22][23] showing an association between recurrent miscarriage and low birthweight. 22,23 For women who have had one fetal loss, most studies have found a reduced mean birthweight or a higher proportion of growth retardation among infants born immediately after the spontaneous abortion, 9,10,24,25 but not all.…”

“…Women who experience habitual abortions (at least three consecutive miscarriages) seem to give birth to liveborn infants with lower birthweight than average, 10,[21][22][23] showing an association between recurrent miscarriage and low birthweight. 22,23 For women who have had one fetal loss, most studies have found a reduced mean birthweight or a higher proportion of growth retardation among infants born immediately after the spontaneous abortion, 9,10,24,25 but not all. 8,[26][27][28] We find that mean birthweight of liveborn infants born after a fetal loss are significantly reduced independent of whether the loss is an early or late stillbirth, also when adjusting for gestational age.…”