Study of the cell proliferation index (Ki67) in inflammatory odontogenic cysts

Diatta, Mamadou; Gadji, Macoura; Diémé, Marie Jeo; Sarr, Souleymane; Kéita, M; Kane, M.; Bâ, Amadou; Gassama, Bintou Catherine; Tamba, Babacar; Tine, Soukèye Dia

doi:10.1016/j.adoms.2023.100431

Advances in Oral and Maxillofacial Surgery

2023

DOI: 10.1016/j.adoms.2023.100431

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Study of the cell proliferation index (Ki67) in inflammatory odontogenic cysts

Mamadou Diatta

Macoura Gadji

Marie Jeo Diémé

et al.

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2024

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Cited by 2 publications

References 16 publications

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Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study

Bhola,

Narwal,

Kamboj

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

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Odontogenic cysts are a diverse group of pathologic entities with different proliferation potential, leading to variations in their biological behavior. One of the most cited proliferation markers used in diagnostic histopathology is Ki-67. Another group of proteins recently investigated is minichromosome maintenance (MCM-3) and its expression has been evaluated in several odontogenic lesions but the results were controversial. Thus, the present study endeavored to compare the expression of MCM-3 and Ki-67 in odontogenic cysts. Furthermore, a pioneer attempt was made to evaluate the sensitivity of these markers to inflammation. A total of 101 cases (37 dentigerous cysts, 37 odontogenic keratocysts, and 27 radicular cysts) were included. Immunohistochemical expression of Ki-67 and MCM-3 were investigated using a labeling index (LI). In addition, they were scored for inflammation, followed by correlation with both markers. The data obtained were subjected to statistical analysis (P<0.05). Overall, a higher LI of MCM-3 than Ki-67 was obtained in all study groups along with a positive correlation of Ki-67 LI with inflammation. Thus, MCM-3 proteins proved to be a more accurate means to determine the proliferation potential and were not sensitive to external stimuli like inflammation than conventional markers, such as Ki-67.

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Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study

Bhola,

Narwal,

Kamboj

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

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CD34 and Ki-67 Immunoexpression in Periapical Granulomas: Implications for Angiogenesis and Cellular Proliferation

Roi,

Riviș,

Roi

et al. 2024

Diagnostics

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Background/Objectives: The main mechanism of the formation of granulation tissue is the progression of an infection from the tooth to the periapical bone. At this level, the immune system tries to localize and annihilate the microorganism’s injury. Ki-67 is a protein directly associated with the cell proliferation rate, while CD34 is a biomarker involved in angiogenesis, and studies suggest that they both have a positive correlation with the intensity of the local inflammatory infiltrate. This study will determine the immunoexpression of CD34 and Ki-67 in periapical granulomas and assess their impact on the growth and development of this tissue, as well as consider their roles in the proliferative process and aggressiveness of evolution. Methods: In the present study, 35 periapical granulomas obtained after a tooth extraction were included. The specimens were analyzed via histopathology and immunohistochemistry. Results: A positive reaction for the Ki-67 antibody was observed in 32 (86.5%) of the 35 periapical granuloma cases included in our study. We identified the overexpression of Ki-67 and CD34 and further calculated the Ki-67 index to evaluate and correlate the proliferation potential and angiogenesis with regard to the presence of an inflammatory infiltrate. Conclusions: These findings suggest that the persistence of an inflammatory environment directly influences Ki-67 and CD34 expression, sustaining the proliferative capacity of cells and abnormal angiogenesis. This study is the first to evaluate the presence of the CD34+ and Ki-67+ proliferating vessels in periapical granulomas.

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Study of the cell proliferation index (Ki67) in inflammatory odontogenic cysts

Cited by 2 publications

References 16 publications

Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study

Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study

CD34 and Ki-67 Immunoexpression in Periapical Granulomas: Implications for Angiogenesis and Cellular Proliferation

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