Gas sweetening unit, also known as acid gas removal unit, is a wide used unit in refineries and petrochemical plants and refers to a group of processes that use different amines such DiEthanolAmine (DEA) to remove the hydrogen sulfide (H 2 S) from gases, in order to use them as fuel to different furnaces from other processing units. If the hydrogen sulfide is not well removed, will lead to furnaces tubular corrosion and therefore will generate loss in refractory properties. Also, the emission values of the exhaust gases will not be in accordance with the environmental regulations. The paper outlines the main results obtained by authors concerning the advanced control solution for a refinery gas sweetening unit and contains three parts. The first part outlines the results of the dynamic gas sweetening process investigation using HYSYS ® simulation software. The second part presents the proposed structure of the advanced control system and the third part outlines the results obtained using the control structure in order to remove as good as possible the H 2 S content from residual gases.