During the mining of deep mineral resources, the rock is in the complex mechanical environment of high crustal stress and blasting excavation unloading, and the improved SHPB test system is used to carry out frequent impact disturbance test of deep rock in the process of unloading high static stress. Firstly, the general characteristics of dynamic stress-strain curve envelope of the whole process trend can be divided into four stages: the stable development stage of micro cracks, the non-stable development stage of micro cracks, the fatigue damage stage, and the fatigue failure stage. Then, the damage variables of the rock are defined by continuous factors, strain equivalence principle and statistical damage theory, which are based on the whole deformation characteristics of rock during the test. And the derived damage variable equation of rock in the damage process is proved to be reasonable, and the damage constitutive model of rock under frequent disturbances in the process of unloading high static stress is established by the combined model method. Finally, the rationality of constitutive equation is verified by test data, which shows that the dynamic stress-strain curve envelope is in good consistency with the theoretical curve of constitutive equation.