Study of the Disappearance of Congo Red From the Blood of Non-Amyloid Subjects and Patients With Amyloidosis

Amyloidosis in Rheumatoid Arthritis, and Significance of "Unexplained" Albuminuria

“…On the clinical side, reports have been for the most part confined to single or at most two cases. The only clinical investigation of a population of rheumatoid arthritics for amyloidosis has been that of Unger et al (1948), who studied 52 rheumatoid patients by means of a modified Congo-red test, and found the complication to be present in six. Reece and Reynolds (1954) found five instances of amyloidosis with rheumatoid arthritis when all patients with the latter condition who attended their hospital from 1935 onwards were reviewed.…”

“…For various reasons it was not possible to investigate a further four of these patients. The seven remaining cases were investigated by the modified Congo-red test of Unger et al (1948) or by liver biopsy, or by both methods.…”

Simultaneous Distribution of T-1824 and I131-Labelled Human Serum Albumin in Man 1

“…In rare instances, such as in secondary amyloidosis (55,56) or following the administration of polyvinyl pyrrolidone (57), there may be successful competition for T-1824 by abnormally reactive substances whose dye affinities exceed those .of plasma proteins.…”

Toxicological effects of Evans blue and Congo red on blood platelets

“…Concentrations reached during diagnostic use of the 2 dyes in human plasma are 5.5 to 7.5 x 10-6 mmole/ml of EB [29,30] and 5 to 8 x 10 5 mmole/ml of CR [31]. In human plasma 6 to 7 x 10-4 mmole/ml albumin is available to bind and inactivate the dyes [32].…”