Study of the distribution of albendazole-sulphoxide (ABZ-SO) in fertilized egg compartments

Navarro, Marc; Cristòfol, Carles; Manesse, Maël; Sautet, J.; Carretero, Ana; Pérez‐Aparicio, Francisco Javier; Arboix, M.; Ruberte, Jesús

doi:10.1016/s1056-8719(97)00018-x

Cited by 1 publication

(1 citation statement)

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“…There is also a lack of data about the pharmacokinetics of ricobendazole. Some available data describe only the distribution of SOX in eggs of laying hens after drug administration directly into the eggs (Navarro et al , ). At present, in the pharmacotherapy of birds, only flubendazole from the benzimidazole compounds is used.…”

Section: Discusionmentioning

confidence: 99%

Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys

Grabowski

Jaroszewski

Swierczewska

et al. 2011

Biomed. Chromatogr.

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Methods for determination of albendazole (ALB), albendazole sulfoxide (SOX) and albendazole sulfone (SON) in turkey blood plasma, using high-performance liquid chromatography (HPLC) with fluorescence detection, were developed. Moreover, comparison of HPLC columns with ultra-performance liquid chromatography (UPLC) columns was performed. Albendazol was administered orally in 5-week-old birds (n = 18) at a dose of 25 mg/kg b.w. Accuracy and precision of the developed method were satisfactory and stability studies showed acceptable variation (below 15%) in ALB, SOX and SON concentrations when the samples were stored at -75°C for 15 days. UPLC(®) columns gave higher peaks from typical HPLC columns retaining high quality of analysis. Pharmacokinetic analysis indicated quick elimination of ALB from turkey blood plasma. The mean residence time of SON was at least two times longer than that of SOX and four times longer than that of ALB. The elimination half-lives for ALB, SOX and SON were 0.7 ± 0.27, 5.37 ± 6.03, 9.17 ± 5.12 h, respectively. The obtained results indicate that the described method allows for precise determination of albendazole and its metabolites in turkey plasma. Moreover, using UPLC columns in HPLC apparatus results in higher sensitivity as compared with the classical HPLC columns.

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Section: Discusionmentioning

confidence: 99%