Ardisia elliptica is one of Indonesian medicinal plants known as Lampeni. Some studies proved that Ardisia elliptica has activities as antibacterial, antiviral, antiplatelet, antiplasmodial and antiproliferative in cancer cell line. Its leaves contain some phytochemical compounds such as α-amyrin, β-amyrin and Bergenin. The aim of this study was to investigate the effect of Ardisia elliptica ethanolic extract (AEE) on Spraque Dawley rats induced by high fat diet (HFD) and streptozotocin (STZ). These models represent DM type 2 conditions. Animals were divided into six groups, namely normal group, negative control group, positive control group (treat with Metformin) and three level doses of AEE (20 mg/200 gBW; 40 mg/200 gBW and 80 mg/200 gBW). All animals were fed with HFD every day. After acclimatization, animals were induced by STZ 6 mg/200 gBW intraperitoneally. Samples were given 7 days after induction until day 21. Blood glucose level were analysed at day 0, 4, 7, 10, 14 and 21 after sample treatment. Histopathological analyses were done for pancreas organ. The result showed that at day 4, AEE start on 20 mg/200 gBW could decrease blood glucose level significantly (p < 0.05). After 21 days treatment, AEE on 80 mg/200 gBW gave the best effect by decrease blood glucose level until 39%, while on Dose 1 (20 mg/200 gBW) could decrease 22% and on Dose 2 (40 mg/200 gBW) could decrease 28%. Histopathological analyses of pancreas organ showed that AEE could increase the number of β-cell, 48% on Dose 1, 53% on Dose 2 and 37% on Dose 3. This study concluded that Ardisia elliptica has potency to treat Diabetes Mellitus Type2.