Study of the Effect of the Perioperative Administration of Statin on the Prognosis of Percutaneous Coronary Intervention Using the National Health Insurance Claims Database in Japan

Abstract

Percutaneous coronary intervention (PCI) sometimes causes ischemic heart disease (IHD). Statins have a recovery effect on vascular endothelial cell function, and it is suggested that statin administration during PCI may help prevent IHD. However, this has not been validated by a large-scale clinical study. Therefore, we evaluated the relationship between statin administration during PCI and cardiovascular events by analyzing the national claims database, which covers most residents in Japan. We analyzed patients who underwent PCI, who were diagnosed with angina or myocardial infarction, and had been continuously administered statin. Among these patients, we assigned patients who were administered statins for 7 days before the procedure to the exposure group and those who were not to the non-exposure group. After matching patients backgrounds using two statistical methods, we compared the incidence of IHD, atrial brillation, bleeding, and mortality after the procedure. The results indicated lower incident risks of IHD and atrial fibrillation after the procedure in angina patients in the exposure group and lower mortality after the procedure in myocardial infarction patients in the exposure group. These results suggest that perioperative treatment with statin during PCI could improve PCI prognosis.