Study of the effect of antidepressant drugs and donepezil on aluminum-induced memory impairment and biochemical alterations in rats

Abdel-Salam, Omar M.E.; Youness, Eman R.; Morsy, Fatma A.; Mahfouz, Marwa M.; Kenawy, Sanaa A.

doi:10.1007/s00580-014-1994-7

Cited by 10 publications

(4 citation statements)

References 101 publications

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“…Meanwhile, regarding the catalase result, a prior study discovered that CAT over-expression reduced anxiety in mice conducting the zero maze task [84]. Additionally, improved depression-like behavior associated with Alzheimer's disease was shown to be dependent on CAT level increase induced by DPZ administration [85].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

et al. 2020

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Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects in subjects without Dementia is unknown. In this study, we use zebrafish to conduct a deeper analysis of the potential adverse effects of DPZ on the short-term memory and behaviors of normal zebrafish by performing multiple behavioral and biochemical assays. Adult zebrafish were exposed to 1 ppm and 2.5 ppm of DPZ. From the results, DPZ caused a slight improvement in the short-term memory of zebrafish and induced significant elevation in aggressiveness, while the novel tank and shoaling tests revealed anxiolytic-like behavior to be caused by DPZ. Furthermore, zebrafish circadian locomotor activity displayed a higher reduction of locomotion and abnormal movement orientation in both low- and high-dose groups, compared to the control group. Biomarker assays revealed that these alterations were associated with an elevation of oxytocin and a reduction of cortisol levels in the brain. Moreover, the significant increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in muscle tissue suggest DPZ exposure induced muscle tissue oxidative stress and muscle weakness, which may underlie the locomotor activity impairment. In conclusion, we show, for the first time, that chronic waterborne exposure to DPZ can severely induce adverse effects on normal zebrafish in a dose-dependent manner. These unexpected adverse effects on behavioral alteration should be carefully addressed in future studies considering DPZ conducted on zebrafish or other animals.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

et al. 2020

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“…Besides ROS, this speculation is also supported by the variation in the catalase basal levels of each medaka fish. Catalase is primarily a peroxisomal enzyme that catalyzes the enzymatic decomposition of H 2 O 2 , and in rats it is associated with depression-like behavior associated with Alzheimer’s disease improvement [ 52 , 53 ]. Lastly, aggression also has been linked to serotonergic function in a variety of invertebrate and vertebrate species.…”

Section: Discussionmentioning

confidence: 99%

Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics

Audira

Siregar

Chen

et al. 2021

IJMS

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Recently, medaka has been used as a model organism in various research fields. However, even though it possesses several advantages over zebrafish, fewer studies were done in medaka compared to zebrafish, especially with regard to its behavior. Thus, to provide more information regarding its behavior and to demonstrate the behavioral differences between several species of medaka, we compared the behavioral performance and biomarker expression in the brain between four medaka fishes, Oryzias latipes, Oryzias dancena, Oryzias woworae, and Oryzias sinensis. We found that each medaka species explicitly exhibited different behaviors to each other, which might be related to the different basal levels of several biomarkers. Furthermore, by phenomics and genomic-based clustering, the differences between these medaka fishes were further investigated. Here, the phenomic-based clustering was based on the behavior results, while the genomic-based clustering was based on the sequence of the nd2 gene. As we expected, both clusterings showed some resemblances to each other in terms of the interspecies relationship between medaka and zebrafish. However, this similarity was not displayed by both clusterings in the medaka interspecies comparisons. Therefore, these results suggest a re-interpretation of several prior studies in comparative biology. We hope that these results contribute to the growing database of medaka fish phenotypes and provide one of the foundations for future phenomics studies of medaka fish.

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“…This speculation is also supported by the variation in catalase's basal levels of each medaka fish. Catalase is primarily a peroxisomal enzyme that catalyzes the enzymatic decomposition of H2O2, and in rats, it is associated with depression-like behavior associated with Alzheimer's disease improvement [46,47]. Lastly, aggression also has been linked to serotonergic function in a variety of invertebrate and vertebrate species.…”

Section: Discussionmentioning

confidence: 99%

Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics

Audira¹,

Siregar²,

Chen³

et al. 2021

Preprint

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Recently, medaka has been used as a model organism in various research fields. However, even though it possesses several advantages over zebrafish, fewer studies were done in medaka than zebrafish, especially its behaviour. Thus, to provide more information regarding its behaviour and to demonstrate the be-havioural differences between several species of medaka, we compared the behavioural performance and biomarker expression in the brain between four medaka fishes, which were Oryzias latipes, O. dancena, O. woworae, and O. sinensis. From the results, we found that each medaka species explicitly exhib-ited different behaviours to each other, which might be related to the different basal levels of several biomarkers. Furthermore, by phenomics and ge-nomic-based clustering, the differences between these medaka fishes were further investigated. Interestingly, even though both phenomics and ge-nomic-based clustering showed some resemblances to each other in terms of the interspecies relationship between medaka and zebrafish, however, in the medaka interspecies comparisons, this similarity was not displayed. Therefore, these results suggest a re-interpretation of several prior studies in comparative biology. We hope that these results contribute to the growing database of medaka fish phenotypes and provide one of the foundations for future phe-nomics studies of medaka fish.

show abstract

Study of the effect of antidepressant drugs and donepezil on aluminum-induced memory impairment and biochemical alterations in rats

Cited by 10 publications

References 101 publications

Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics

Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics

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