Study of the efficacy of carboxytherapy in alopecia

Doghaim, Noha Nabil; El‐Tatawy, Rania Ahmed; Neinaa, Yomna Mazid El‐Hamd; El‐samd, Marwa Mohsen Abd

doi:10.1111/jocd.12501

Cited by 24 publications

(29 citation statements)

References 21 publications

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“…14 Regarding wound healing resulting specifically from chronic venous insufficiency, it is known that the repair process occur slowly, and it is insufficient because the migration of cells is inefficient, which causes the chronicity of this condition as the region cannot be reepithelialised, 15 resulting in dysfunctional tissue in the affected area. 3 The literature on the improvement of this condition does not present concise and recent findings, so we consider the choice of the carboxytherapy in this study because the carbon dioxide used in this process is non-toxic, cost-effective, and safe 16,17 and I II III I II III I II III I II I II III I II III I II III I II respects the principle primum non nocerae (first of all not to prejudice), aiming to stimulate, or at least not inhibit, cell replication. 18 The present study confirmed the decrease of the inflammatory process after treatment with carboxytherapy, which promotes an increase of cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Brochado¹,

Schweich

Simões³

et al. 2018

International Wound Journal

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To examine the influence of carboxytherapy on wound healing under venous insufficiency, full‐thickness excisional wounds were created on Wistar rats. We used three groups with 32 rats each: Group (I): daily cleaning with 0.9% saline solution; Group Sulfadiazine (II): 1% silver sulfadiazine; and Carboxytherapy (III): subcutaneous application of 0.3 mL of carbon dioxide. The predetermined periods of analysis were the 3rd, 7th, 14th, and 30th day. The slides were stained with haematoxylin and eosin and Picrosirius red and submitted for immunohistochemistry. Groups II and III presented a statistically significant decrease in relation to the presence of neutrophilic and lymphocytic infiltrates. The presence of collagen significant increased in groups II and III. However, group III presented better organisation. Only group I maintained the neovascularisation until the 30th day. The new epithelium statistically significantly increased in groups II and III. On immunohistochemistry, regarding fibronectin expression, only group III demonstrated a statistically significant increase since the beginning of the healing process. Thus, the use of carboxytherapy promotes the formation of a tissue better structured and that may be an important resource for the treatment of wounds under venous insufficiency, especially those of recurrent re‐openings.

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Section: Discussionmentioning

confidence: 99%

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Brochado¹,

Schweich

Simões³

et al. 2018

International Wound Journal

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“…In the study by Doghaim et al, 30 rates. Overall, they found that the mSALT and some dermoscopic parameters improved significantly and quickly, which were persistent, leading to a 100% reduction after the last follow-up session.…”

Section: Alopeciamentioning

confidence: 92%

Carboxytherapy in dermatology: A systematic review

Ahramiyanpour

Shafie’ei

Sarvipour

et al. 2022

J of Cosmetic Dermatology

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Introduction The overall effects of Carboxytherapy, defined as the administration of carbon dioxide, have been studied for many years. It has been suggested that by improving oxygenation, interacting with the tissue perfusion regulators, and disrupting the adipose cell membranes, the method can lead to notable improvements in different esthetic and pathological conditions. Therefore, we aimed to systematically review the available studies evaluating the potential benefits of carboxytherapy in dermatological conditions and how it objectively stands against scientific scrutiny. Methods We searched the PubMed, Scopus, Embase, and Web of Science databases, including the studies exploring the method's efficacy in managing any dermatological condition. Results A total 27 of studies were identified (with a pooled sample of over 700 cases), most of which were clinical trials. Facial wrinkles, periorbital hyperpigmentation, skin laxity deficiency, scars, striae distensae, localized lipolysis and cellulite, alopecia, chronic diabetic wounds, and psoriatic plaques comprised the package of the dermatological conditions that were studied. Except for a few studies, the method mainly demonstrated significant improvements on all of the mentioned conditions. The inter‐ and post‐operational adverse events were mild and transient, including erythema, pain, crepitus, and ecchymoses. Discussion Carboxytherapy can provide those practicing in the field with sustainably favorable results. However, the numbers of cases on whom the fat‐reducing capabilities of the method were studied and experienced varying degrees of recurrence caught our eye. In addition, we observed a notable disparity between the outcome measures utilized in the studies. The modest sample size in each condition also added to the injury, as the conditions on which the method was evaluated are pretty common in the general population. Therefore, for a definite conclusion, more randomized controlled trials with the shortcomings mentioned well addressed need to be conducted.

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“…The technique was used by cardiologists in the 1950s to treat patients with peripheral arterial occlusive pathologies. The term “carboxytherapy” was created in 1995 by Luigi Parassoni during the XVI National Meeting of the Italian Society of Aesthetic Medicine 1,2,3…”

Section: Introductionmentioning

confidence: 99%

“…The controlled CO 2 infusion is considered a safe, nonsurgical procedure consisting of applying medicinal carbon dioxide to the skin and adipose tissue 4. Therapeutic indications for CO 2 include vascular, cardiac, metabolic and rheumatic pathologies, cellulitis, chronic wounds, localized adiposities, migraine, stretch marks, wrinkles, unaesthetic scars, and skin laxity 2,5,6,7…”

Section: Introductionmentioning

confidence: 99%

Effects of carboxytherapy on skin laxity

Oliveira

Rocha

Cunha

et al. 2020

J of Cosmetic Dermatology

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Background Carboxytherapy is capable of inducing tissue repair which results in an increase in elastic and collagen fibers. Objectives To evaluate the effects of carboxytherapy upon human skin collagen and elastic fiber synthesis. Methods Case study of nine volunteers who received a single application of carboxytherapy in the left infraumbilical region, with infusion rate of 100 mL/min and 0.6 mL/kg weight over an area of 25 cm2. After 60 days on average, the skin was collected for histological analysis and stained with picrosirius red for collagen and Verhoeff for elastic fibers. The percentage of fibers found was marked by the Image J® program and recorded in a Microsoft Excel spreadsheet. Statistical analysis was performed using SPSS (version 20), with a significance level of 95%. Results An increase in the collagen and elastic fibers sample was observed in the treated group. Morphometrically, a significant increase in the percentage of collagen in the Carboxytherapy group (41.44 ± 4.50%) was observed compared with the control group (37.44 ± 3.87%) with P = .04; for elastic fibers, the percentage showed no significant difference between the control group (10.55 ± 4.33%) and the carboxytherapy group (10.44 ± 3.71%). Conclusions Carboxytherapy with the parameters used in this study was able to stimulate collagen and elastic fiber synthesis, with significant differences in the morphometry for collagen fibers.

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Study of the efficacy of carboxytherapy in alopecia

Abstract: Carboxytherapy seems to be a promising therapeutic option for patchy AA and could be helpful as an adjuvant therapy of AGA but more than 6 sessions are required and adjuvants are recommended for maintenance of the results.

Cited by 24 publications

References 21 publications

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency

Carboxytherapy in dermatology: A systematic review

Effects of carboxytherapy on skin laxity

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