Study of the excitation functions for 43K, 43,44,44mSc and 44Ti by proton irradiation on 45Sc up to 37MeV

Dârâban, L.; Rebeles, R. Adam; Hermanne, Alex; Tárkányi, F.; Takács, S.

doi:10.1016/j.nimb.2009.01.010

Cited by 24 publications

(20 citation statements)

References 12 publications

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“…The first route involves the production of the long-lived parent 44 Ti at an intermediate energy accelerator. The cross sections of the 45 Sc(p,2n) 44 Ti nuclear reaction have been well investigated [18,19] and the energy range Ep= 35 → 15 MeV appears to be very suitable for production purposes. The calculated thick target yield of 44 Ti over this energy range amounts to ~ 4 kBq A -1 h -1 (for 1 h irradiation).…”

Section: Production Of 44g Scmentioning

confidence: 99%

New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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A brief historical background of the development of the theranostic approach in nuclear medicine is given and seven theranostic pairs of radionuclides, namely 44g Sc/ 47 Sc, 64 Cu/ 67 Cu, 83 Sr/ 90 Sr, 86 Y/ 90 Y, 124 I/ 131 I, 152 Tb/ 161 Tb and 152 Tb/ 149 Tb, are considered. The first six pairs consist of a positron and a β −-emitter whereas the seventh pair consists of a positron and an α-particle emitter. The decay properties of all those radionuclides are briefly mentioned and their production methodologies are discussed. The positron emitters 64 Cu, 86 Y and 124 I are commonly produced in sufficient quantities via the (p,n) reaction on the respective highly enriched target isotope. A clinical scale production of the positron emitter 44g Sc has been achieved via the generator route as well as via the (p,n) reaction, but further development work is necessary. The positron emitters 83 Sr and 152 Tb are under development. Among the therapeutic radionuclides, 89 Sr, 90 Y and 131 I are commercially available and 161 Tb can also be produced in sufficient quantity at a nuclear reactor. Great efforts are presently underway to produce 47 Sc and 67 Cu via neutron, photon and charged particle induced reactions. The radionuclide 149 Tb is unique because it is an α-particle emitter. The present method of production of 152 Tb and 149 Tb involves the use of the spallation process in combination with an on-line mass separator. The role of some emerging irradiation facilities in the production of special radionuclides is discussed.

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Section: Production Of 44g Scmentioning

confidence: 99%

New developments in the production of theranostic pairs of radionuclides

Qaim

Schölten

Neumaier

2018

J Radioanal Nucl Chem

132

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“…Nonetheless, from the scientific and application point of view (see below), it appears worthwhile to develop it further. The suggested production reaction is 45 Sc( p, 2n) 44 Ti and the excitation function, recently measured [141], is reproduced in Fig. 8.…”

Section: Production Of Novel Parent Generator Radionuclidesmentioning

confidence: 54%

“…Nonetheless two generator systems for obtaining the daughter 72 As, one based on distillation [137] and the other one on solid phase extraction [138] have been developed. With regard to 140 Nd, the ( p, 2n) and ( 3 He, xn) reactions on 141 Pr and nat Ce, respectively, have been investigated in detail [cf . 139].…”

Section: Production Of Novel Parent Generator Radionuclidesmentioning

confidence: 99%

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Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

Qaim¹

2011

Ract

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In molecular imaging, the importance of novel longer lived positron emitters, also termed as non-standard or innovative PET radionuclides, has been constantly increasing, especially because they allow studies on slow metabolic processes and in some cases furnish the possibility of quantification of radiation dose in internal radiotherapy. Considerable efforts have been invested worldwide and about 25 positron emitters have been developed. Those efforts relate to interdisciplinary studies dealing with basic nuclear data, high current charged particle irradiation, efficient radiochemical separation and quality control of the desired radionuclide, and recovery of the enriched target material for reuse. In this review all those aspects are briefly discussed, with particular reference to three radionuclides, namely 64 Cu, 124 I and 86 Y, which are presently in great demand. For each radionuclide several nuclear routes were investigated but the ( p, n) reaction on an enriched target isotope was found to be the best for use at a small-sized cyclotron. Some other positron emitting radionuclides, such as 55 Co, 76 Br, 89 Zr, 82m Rb, 94m Tc, 120 I, etc., were also produced via the low-energy ( p, n), ( p, α) or (d, n) reaction. On the other hand, the production of radionuclides 52 Fe, 73 Se, 83 Sr, etc. using intermediate energy ( p, xn) or (d, xn) reactions needs special consideration, the nuclear data and chemical processing methods being of key importance. In a few special cases, a high intensity 3 He-or α-particle beam could be an added advantage. The production of some potentially interesting positron emitters via generator systems, for example 44 Ti/ 44 Sc, 72 Se/ 72 As and 140 Nd/ 140 Pr is considered. The significance of new generation high power accelerators is briefly discussed.

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“…In our experiments natural scandium was irradiated with 12-10 MeV protons for several reasons: -The energy is below the threshold of 12.7 MeV of the 45 Sc( , 2 ) 44 Ti nuclear reaction [30], which would lead to a radioisotopic impurity that could not be separated chemically and would interfere with the X-ray measurement and the -coincidence counting (see Table 1). Concerning the measurements, it was important to employ the right amount of radioactivity suiting the requirements of all used counting techniques.…”

Section: Resultsmentioning

confidence: 99%

Positron and γ-ray intensities in the decay of ⁴⁵Ti

Kuhn¹,

Schölten²,

Spahn³

et al. 2015

Radiochimica Acta

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Abstract:To evaluate the PET-imaging properties of the promising positron emitter 45 Ti, its + -and -ray intensities were measured. Use of the cation-exchange resin DOWEX 50W×8 (H + -form) enabled the isolation of radiochemically pure, no-carrier-added 45 Ti from "bulk" scandium after proton bombardment. Thin, no-carrier-added 45 Ti samples were prepared. The combination of -ray and X-ray spectrometry with -coincidence counting allowed for the first time the experimental determination of the positron intensity as (85.67 ± 2.23)% and the absolute intensity of the 720.22 keV -ray as (0.1171 ± 0.0057)%.

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Study of the excitation functions for 43K, 43,44,44mSc and 44Ti by proton irradiation on 45Sc up to 37MeV

Cited by 24 publications

References 12 publications

New developments in the production of theranostic pairs of radionuclides

New developments in the production of theranostic pairs of radionuclides

Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

Positron and γ-ray intensities in the decay of ⁴⁵Ti

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Study of the excitation functions for 43K, 43,44,44mSc and 44Ti by proton irradiation on 45Sc up to 37MeV

Cited by 24 publications

References 12 publications

New developments in the production of theranostic pairs of radionuclides

New developments in the production of theranostic pairs of radionuclides

Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

Positron and γ-ray intensities in the decay of 45Ti

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Positron and γ-ray intensities in the decay of ⁴⁵Ti