Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence

Abstract

An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur®-a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of antirelapse immune corrector Arecur® in the patients' management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.

COPD: Perspectives of Immune Peptide Therapy and Lung Cancer Prevention

“…Studies have shown that contact of immune peptides with mucosal cells significantly increases the expression of secretory immunoglobulin A. [25] The ability of immune proteins to stimulate macrophage migration and induce apoptosis of atypical cells opens new possibilities for the use of antirelapse immunocorrection [26] Encouraging clinical results of the use of immune proteins for the prevention of cancer recurrence were obtained [27,28].…”

Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

“…In this regard, the most interesting is the nonspecific mechanism of activation by immune proteins of immunocompetent cells. Due to the effect of tissue accumulation, immune peptides attach to cell membranes in the target organ and thus provoke their more productive interactions with T-lymphocytes, NK-cells and macrophages [33,34,37]. On the one hand, interacting with the ectopically located endometrial tissue, RJP-1 reduces perifocal inflammation, on the other hand, defensins stimulate the synthesis of TNF-α by macrophages.…”