Study of the functional state of peripheral vessels in fingers of rheumatological patients by means of laser Doppler flowmetry and cutaneous thermometry measurements

Zherebtsova, Angelina I.; Zherebtsov, Evgeny; Dunaev, Andrey V.; Podmasteryev, K. V.; Pilipenko, O. V.; Крупаткин, А. И.; Khakhicheva, Lyudmila S.; Muradyan, Vadim F.

doi:10.1117/12.2229827

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…Such diseases include diabetes 6, 7 psoriasis 8 and rheumatological diseases. [9][10][11] Also, this method allows one to estimate the oscillatory processes in the microvessels. There are several frequency ranges characterizing the contribution of various factors to the LDF signal: endothelial (0.0095-0.021 Hz), neurogenic (0.021 -0.052 Hz), myogenic (0.052-0.145 Hz), respiratory (0.145-0.6 Hz) and cardiac (0.6-2 Hz).…”

Section: Introductionmentioning

confidence: 99%

Pilot studies of age-related changes in blood perfusion in two different types of skin

Loktionova

Zharkikh²,

Kozlov

et al. 2019

Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine

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Laser Doppler flowmetry (LDF) was utilized to assess age-related changes in the blood microcirculation at the skin sites with different morphology and regulation. The LDF signals obtained from the glabrous skin of the middle finger pad and nonglabrous skin on the dorsal wrist surface were analyzed. Statistically higher baseline perfusion was observed in the zone with glabrous skin in the older group of volunteers compared to younger participants. Observed site-specific and age-related differences in perfusion can be used in the future experimental design for the studies of the blood microcirculation system in patients with different pathologies.

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Section: Introductionmentioning

confidence: 99%

Pilot studies of age-related changes in blood perfusion in two different types of skin

Loktionova

Zharkikh²,

Kozlov

et al. 2019

Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine

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“…LDF is used for functional diagnostics of the blood microcirculation system, including diagnostics of socially significant diseases associated with the cardiovascular system, as well as their complications. [2][3][4] Furthermore, this method allows for the evaluation of the oscillatory processes in the microcirculatory bed. There are several frequency ranges that characterise the contribution of various factors to the LDF signal: endothelial (0.0095-0.021 Hz), neurogenic (0.021-0.052 Hz), myogenic (0.052-0.145 Hz), respiratory (0.145-0.6 Hz) and cardiac (0.6-2 Hz).…”

Section: Introductionmentioning

confidence: 99%

Studies of age-related changes in blood perfusion coherence using wearable blood perfusion sensor system

Loktionova

Zherebtsov

Zharkikh

et al. 2019

Novel Biophotonics Techniques and Applications V

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Laser Doppler flowmetry (LDF) was used for detection of age-related changes in the blood microcirculation. The LDF signal was simultaneously recorded from the 3rd fingers' pads of both hands. Amplitudes of the blood flow oscillations and wavelet coherence of the signals were used for the data analysis. A statistical difference in the synchronisation of myogenic oscillations was found between the two studied age groups. Myogenic oscillations of blood perfusion in the younger group had a higher wavelet coherence parameter than in the older group. Observed site-specific and age-related differences in blood perfusion can be used in the future in the design of experimental studies of the blood microcirculation system in patients with different pathologies.

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“…47 For a comprehensive diagnosis of the state of microcirculatory-tissue systems, applying several diagnostic technologies simultaneously in one diagnostic volume is currently promising. 31,48,49 To assess the state of blood flow and detect possible vascular disorders, different combinations of methods are applied. For instance, simultaneous measurements of the intensities of fluorescence and Rayleigh components in human eye lenses allow a good accuracy to separate patients with diabetes from a control group.…”

Section: Introductionmentioning

confidence: 99%

Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

et al. 2017

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According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

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Study of the functional state of peripheral vessels in fingers of rheumatological patients by means of laser Doppler flowmetry and cutaneous thermometry measurements

Cited by 10 publications

References 7 publications

Pilot studies of age-related changes in blood perfusion in two different types of skin

Pilot studies of age-related changes in blood perfusion in two different types of skin

Studies of age-related changes in blood perfusion coherence using wearable blood perfusion sensor system

Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

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