Study of the Glucose Sensor Based on Potentiometric Non-Enzymatic Nafion/CZO Thin Film

Chou, Jung-Chuan; Huang, Yuhao; Lai, Chih-Hsien; Nien, Yu–Hsun; Kuo, Po-Yu; Su, Tzu-Yu; Kang, Zhi-Xuan

doi:10.1109/jsen.2021.3076068

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…Over time, the response voltage of the sensor gradually approaches stability. Therefore, we selected 95 % of the stable voltage as the termination point of the response time [33] to ensure that the measured response time is sufficiently reliable and accurate. In this experiment, we also further tested the response time at different pH values to compare the measurement characteristics at different pH values, which helps to further verify the sensing performance of the Nafion/APTES/MgO pH sensor.…”

Section: E Response Time Of the Nafion/aptes/mgo Ph Sensormentioning

confidence: 99%

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

Yang,

Huang,

Chang

et al. 2024

IEEE J. Electron Devices Soc.

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In recent years, research in the field of sensors has been rapidly advancing. As a result, this study proposes a pH sensor based on a magnesium oxide (MgO) thin film. The MgO sensing layer of the pH sensor was deposited onto the electroless nickel immersion gold (ENIG) electrode using a radio frequency (RF) sputtering system, where the ENIG electrode is integrated as the working electrode and reference electrode on a Flexible Printed Circuit Board (FPCB). FPCB offers advantages such as flexibility, acid resistance, heat resistance, and low cost. Furthermore, the performance of the pH sensor is enhanced by modifying the sensing layer with Nafion and (3-Aminopropyl)triethoxysilane (APTES). This study utilized the potentiometric method to measure and analyze the performance of the pH sensor, and the measurement range of the pH sensor is from pH 3 to pH 11 with an average sensitivity of 46.48 mV/pH and linearity can reach 0.996. In terms of material analysis, this research utilizes atomic force microscopy (AFM) and energy dispersive X-ray spectroscopy (EDX) to analyze the surface morphology and elemental composition of the sensing layer to verify MgO film.

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Section: E Response Time Of the Nafion/aptes/mgo Ph Sensormentioning

confidence: 99%

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

Yang,

Huang,

Chang

et al. 2024

IEEE J. Electron Devices Soc.

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“…When the response voltage was stable, 250 μL of 6 mg/dL (0.33 mM) concentration uric acid solution was added to the solution. Then, waiting for the response voltage to be stable, we can measure the response voltage from 0% to 95 % time interval [34]. Fig.…”

Section: E Response Time Of the Uric Acid Sensormentioning

confidence: 99%

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Yang

Chan

Chang

2023

IEEE J. Electron Devices Soc.

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This study prepared an enzymatic potentiometric uric acid sensor based on zinc oxide (ZnO) and uricase. Also, we develop a potentiometric differential measurement system. We applied Nafion, APTES, and glutaraldehyde to immobilize the enzyme and increase sensitivity to prevent enzyme leakage. Thus, the uric acid sensor was integrated into FPCB which could provide flexibility to the sensor. In the uric acid concentration range of 2 mg/dL-10 mg/dL, we analyzed the characteristics of sensors with the voltage-time measurement system, measuring the average sensitivity, linearity, response time, limit of detection (LOD), and interference effects. The modification of Nafion and uricase improved the performance of the uric acid sensor.

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“…conditions, healthy persons have a blood glucose level of roughly 3.9 mM-5.5 mM, whereas adults with diabetes have a blood glucose level of around 4.4 mM-7.2 mM. This implies that persons who have diabetes have higher blood glucose levels than those who do not [3]. This major global public health issue, which can harm nerves, blood vessels, and organs, is expected to double to 300 million people by 2025 [6].…”

mentioning

confidence: 99%

“…Since then, non-enzymatic glucose sensor research has sparked a lot of interest, with a variety of technologies and materials being used. Various attempts have recently been made to use electrochemical-based technologies for nonenzymatic glucose detection with quick response and precise readings such as cyclic voltammetry (CV), amperometric measurements, potentiometric measurements, colorimetric determination, FET based sensor, etc [2], [3], [17]- [21]. In comparison to previous detection approaches, field-effect transistors (FETs) adopting diverse nanostructures provide a stable and economically practical platform for achieving high current amplification with a sustained and increased signal-to-noise ratio.…”

mentioning

confidence: 99%

Non-Enzymatic Glucose Detection Based on GO/Ag Nanocomposite in SiO₂Trench Embedded Field Effect Transistor

Naorem

Paily

2022

IEEE Sensors J.

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This study demonstrates the application of graphene oxide-silver (GO/Ag) nanocomposite to develop a non-enzymatic high-performance glucose-sensing fieldeffect transistor (FET). Lithography and etching processes are used to fabricate the SiO 2 trench embedded FET. The fabricated device structure was used not only for glucose storage but also for glucose sensing. The bonding of the GO/Ag nanocomposite was validated by analysing their shape and structure. As the concentration of glucose rises (1 μM to 10 mM range), the output electrical signal changes. With a 1 μM limit of detection (Signal to Noise ratio, S/N > 3), the sensor has a response time of fewer than 5 seconds. It also demonstrated great long-term stability, outstanding reproducibility, and excellent glucose selectivity. This sensor has notable characteristics such as ease of production, simplicity of usage, and small size. It has the potential to fabricate portable glucose sensors for point-of-care sensing in the future. Additional liquid sensing applications could benefit from the sensor structure.

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Study of the Glucose Sensor Based on Potentiometric Non-Enzymatic Nafion/CZO Thin Film

Cited by 10 publications

References 36 publications

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Non-Enzymatic Glucose Detection Based on GO/Ag Nanocomposite in SiO₂Trench Embedded Field Effect Transistor

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Study of the Glucose Sensor Based on Potentiometric Non-Enzymatic Nafion/CZO Thin Film

Cited by 10 publications

References 36 publications

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

Potentiometric MgO Film pH Sensor Measurement Analysis and Integrated Flexible Printed Circuit Board

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Non-Enzymatic Glucose Detection Based on GO/Ag Nanocomposite in SiO2Trench Embedded Field Effect Transistor

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Product

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Non-Enzymatic Glucose Detection Based on GO/Ag Nanocomposite in SiO₂Trench Embedded Field Effect Transistor