Study of the Healthy Effects of Different Fat Ratios Mixtures of Omega-3 to Omega-6 in Male Mice with Alloxan-Induced Diabetes

Abstract

This study was conducted at the Iraqi Center for Cancer Research / Al-Mustansiriya University / Baghdad Governorate, for the period from November 2020 to January 2021, to know healthy effects of different fat ratios mixtures of Omega-3 to Omega-6 in male mice with type 2 diabetes induced by Aloxan at a concentration of 100 mg / kg of weight. 32 mice aged (2-3) months and their weight (25-30) g were included. Four mice were isolated from them as a healthy control group and the remaining mice were injected with alloxan. Infected mice were divided into seven groups, one of which was untreated group (infected control), while the rest were treated with mixtures of different proportions of omega 6 and 3 fats. After the 30-day experiment, the biological study showed that the introduction of experimental diabetes mellitus with alloxan led to a higher Significant (p>0.01) and (P>0.05) in the concentration of glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol (VLDL-C) compared with the proper control group. While it led to a significant decrease (p>0.01) and (p>0.05) in high-density lipoprotein-cholesterol (HDL-C) concentrations in the affected control group, but when using mixtures of different proportions of omega-6 fats: Omega-3 led to a decrease in the concentration of glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol (VLDL-C) compared with the infected and untreated control group and an increase in concentrations of high-density lipoproteins (HDL-C) cholesterol.