Study of the Homogeneity of Drug Loaded in Polymeric Films Using Near-Infrared Chemical Imaging and Split-Plot Design

Alexandrino, Guilherme L.; Poppi, Ronei J.

doi:10.1002/jps.24051

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…One of the important applications of such experiment is for reducing the variation and achieving a robust process. , The split-plot designs were originally developed for use in agricultural experiments, and lately have drawn attention in the industry. For instance, Alexandrino et al used this type of experiment method to study the homogeneity of the drug paracetamol loaded in films. Antohe et al validated the optimal annealing conditions applying this type of DoE method when they analyzed thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing.…”

Section: Introductionmentioning

confidence: 99%

Numerical and Statistical Analyzing of the Effect of Operating Parameters on Syngas Yield Fluctuation in Entrained Flow Coal Gasification Using Split-Plot Design

et al. 2017

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For a coal-based production system with entrained flow coal gasification, the fluctuations in syngas yield (SY) affect the stability of downstream sections directly. The focus of this study is to analyze how some important operating parameters affect these fluctuations in SY for a typical entrained flow coal gasification, Shell coal gasification process (SCGP). In this study, we carried out a set of numerical simulation experiments in Aspen Plus simulator for a demonstration SCGP gasifier. These experiments were arranged using a special design of experiment (DoE) method, split-plot design. Then we systematically analyzed the effects of pressure (P), oxygen to coal ratio (O/C), and steam to coal ratio (S/C) on the Range and standard deviation (StDev) of SY using some statistical techniques. The results show that split-plot design is an appropriate DoE method to investigate and analyze the effects of the operating parameters on the fluctuations in SY. For the demonstration SCGP process, the fluctuations in SY are mainly affected by P and O/C. Among them, P is the dominant factor and O/C is an important factor, while S/C influences the fluctuations in SY slightly. The lowest Range and StDev of SY could be obtained only when P is at a higher level and O/C as well as S/C is at a lower level. This is the ideal condition for realizing a moderate robust syngas production.

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Section: Introductionmentioning

confidence: 99%

Numerical and Statistical Analyzing of the Effect of Operating Parameters on Syngas Yield Fluctuation in Entrained Flow Coal Gasification Using Split-Plot Design

et al. 2017

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“…An alternative to this method will be the perform the experiment in blocks by application of a split-plot design, as used by several authors [17]- [22]. The split-plot design would facilitate the feasibly of experiments, but on the other hand, would become quite complex to define the parameter models errors, compared with procedure for a completely randomized design.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Expanded Polystyrene Lightweight Aggregate in Pre-Cast Concrete Blocks by a Completely Random Experimental Design (CRED) with Mixture and Process Variables

Vieira¹,

Vasconcelos²,

Marangoni³

et al. 2016

OJS

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The aim of this study was to determine the optimum design mix to produce precast concrete blocks by a completely random experimental design (CRED) with mixture and process variables. The polymerized concrete was studied its composition: Cement, and water defined as the mixture compounds. To choose the best model, all the possible models were assessed through the ANOVA, which tested each possible model. The linear-linear model was preferred, since that do not present evidence of lack of fit, and it is capable of relating how to react the process variables, when are changed the variable mixture condition levels. The optimum experimental condition, obtained for the polymerized concrete, was: The size of the polystyrene beads was 4.8 mm sized polystyrene beads, 5.0% polystyrene that replaced the aggregate, 18.3% cement, 73.4% aggregate and 8.3% water. In this condition, the blocks made with polymerized concrete show a compressive strength above 15 Mpa, allowing its utilization in paving.

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Multifunctional and multilayer surgical sealant for a better patient safety

Chevala

Kumar

Veetilvalappil

et al. 2022

International Journal of Pharmaceutics

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Study of the Homogeneity of Drug Loaded in Polymeric Films Using Near-Infrared Chemical Imaging and Split-Plot Design

Cited by 3 publications

References 34 publications

Numerical and Statistical Analyzing of the Effect of Operating Parameters on Syngas Yield Fluctuation in Entrained Flow Coal Gasification Using Split-Plot Design

Numerical and Statistical Analyzing of the Effect of Operating Parameters on Syngas Yield Fluctuation in Entrained Flow Coal Gasification Using Split-Plot Design

Optimization of Expanded Polystyrene Lightweight Aggregate in Pre-Cast Concrete Blocks by a Completely Random Experimental Design (CRED) with Mixture and Process Variables

Multifunctional and multilayer surgical sealant for a better patient safety

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