Study of the human infectious safety model under the influence of SARS-CoV-2 on the example of the Perm Krai of the Russian Federation

Abstract

In the new millennium, humanity is faced with infectious diseases that no one previously knew about. In the end of 2019, an outbreak of a new coronavirus infection occurred in the People’s Republic of China (PRC) with an epicenter in the city of Wuhan (Hubei Province). On February 11, 2020, the International Committee on the Taxonomy of Viruses assigned an official name to the infectious agent - SARS-CoV-2. According to the results of serological and phylogenetic analysis, coronaviruses are divided into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus. Currently, four seasonal coronaviruses (HCoV-229E, - OC43, -NL63 and -HKU1) are circulating among the world’s population, which are present year-round in the structure of ARI, and, as a rule, cause damage to the upper respiratory tract of mild and moderate severity, as well as two highly pathogenic coronaviruses-Middle East respiratory syndrome virus (MERS) and new coronavirus infection COVID-19. To develop a model of human resistance to the disease caused by the coronavirus family, the elements, links and ways of protecting the Human-Virus-Environment system were identified. The destructive functions of sixteen proteins of the SARS-CoV-2 strain are considered. Deterministic and statistical models of cells infection risk development have been developed. A parameterized system of human protection against coronavirus infection is proposed.

Impact of the New Coronavirus Infection on the Immune System of Children and Adolescents in the Region of the Russian Federation

“…The second wave was in the autumn of 2020. A study of the human infectious safety model under the influence of SARS-CoV-2 in the territory of Perm Krai is described in [ 9 ]. Building a tool model for the study of the ecosystem “coronavirus—vector—human—environment” is described in [ 23 ].…”

“…In Perm Krai, the first case of a new coronavirus infection (SARS-CoV-2) was detected in March 2020 in a man returning from abroad. Between 2020 and 2021, there were three waves of coronavirus infection, which had an impact on the immune parameters of the residents of Perm Krai [ 9 ]. The large range of issues and phenomena studied in relation to immunity has proved to be complex and varied.…”

"Ecology of Vital Activity as An Element of Antistress Therapy on The Example of The Organization of The Work of a Medical Center with Industrial Enterprises Under the VMI Program"

“…The system includes the following activities: a health school was opened at each enterprise, within the framework of which educational events were held, meetings with doctors of various specialties, schools of healthy nutrition, training of therapeutic and restorative physical education, and systematic classes on anti-stress therapy with specialized specialists [6][7][8][9][10]. In order to combat physical inactivity, we conducted field health days combining competence enhancement in terms of improving the competence of a healthy lifestyle, combining physical activity, gamification of tasks [11][12][13][14][15][16][17][18][19][20], creating a benevolent atmosphere, and a positive emotional background. These systems of measures were analyzed a year later on November 1, 2022.…”