Study of the mechanisms by which Sambucus williamsii HANCE extract exert protective effects against ovariectomy-induced osteoporosis in vivo

Abstract

The present study indicated that SWH could improve bone properties by inhibiting the process of bone resorption and stimulating the process of bone formation.

An 8-O-4′ norlignan exerts oestrogen-like actions in osteoblastic cells via rapid nongenomic ER signaling pathway

“…Our results also demonstrated that PPD modulated the mRNA expression of OPG and RANKL in osteoblastic cells which is consistent with our previous study that SWH could upregulate the expression of OPG/RANKL in tibia (Zhang et al, 2011). RANKL released from osteoblasts is known to bind to RANK, its receptor on the surface of osteoclastic precursor cells, thereby inducing differentiation and activation of these cells into osteoclasts.…”

“…SWH (Caprifoliaceae), as a folk medicine, has been used for treatment of bone and joint diseases in China for thousands of years (Zhong et al, 1985;Song, 2000;Zhao, 2010;Han et al, 2013). Our previous studies showed that SWH extract effectively suppressed ovariectomy-induced increase in bone turnover and improved bone mineral density (BMD) and biomechanical strength in rats (Xie et al, 2005) as well as in mice (Zhang et al, 2011). PPD has been isolated from many plants, such as Cultivar of Helianthus annuus (Macías et al, 2004), fruit of Euterpe oleracea (Chin et al, 2008) and Tsuga dumosa (Zhao et al, 2004).…”

<i>Gentiana macrophylla</i> Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

“…It was observed that G. macrophylla extract enhanced the transcription of Cbfa1 mRNA and cathepsin K mRNA, and increased the ratio of OPG/RANKL mRNA expression in the tibia. The results are well supported by a previous study wherein Sambucus williamsii exhibited similar effects [18]. The results of LC/MS analysis showed the presence of several compounds which may be potentially responsible for the protective effects of the extract.…”

Effects of Phytoestrogen Extracts Isolated from Elder Flower on Hormone Production and Receptor Expression of Trophoblast Tumor Cells JEG-3 and BeWo, as well as MCF7 Breast Cancer Cells

“…The terpenes extracted from elder flower show notably strong antimicrobial effects in vitro upon methicillin-resistant Staphylococcus aureus [24]. Moreover elder flower could improve bone properties by inhibiting the process of bone resorption and stimulating the process of bone formation [25]. …”