Study of the nature of recognition in molecularly imprinted polymers, II

Andersson, Håkan S.; Karlsson, Jesper G; Piletsky, Sergey A.; Koch-Schmidt, Ann-Christin; Mosbach, Klaus; Nicholls, Ian A.

doi:10.1016/s0021-9673(99)00483-5

Cited by 167 publications

(82 citation statements)

References 29 publications

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“…Due to the limited success of the imprinting protocol described above, we pursued a second approach. MIPs P2E and P3E were prepared using a 10-fold excess of the template molecules with respect to 1 [29], with the aim of pushing the respective monomer-template interaction equilibria to favour complex formation. This process was further aided by a change of the polymerisation solution to a 1:1 mixture of ACN and THF.…”

Section: Resultsmentioning

confidence: 99%

Non-covalent imprinting of phosphorous esters

Hall

Lanza-Sellergren

Manesiotis

et al. 2005

Analytica Chimica Acta

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Section: Resultsmentioning

confidence: 99%

Non-covalent imprinting of phosphorous esters

Hall

Lanza-Sellergren

Manesiotis

et al. 2005

Analytica Chimica Acta

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“…(3) The porogenic solvents should be of the selectivity has been well-documented [22,23]. relatively low polarity, in order to reduce the interOnly a proper template-monomer ratio can afford ferences during complex formation between the high selectivity.…”

Section: 4 High-performance Liquid Chromatographymentioning

confidence: 99%

Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers

Huang

Zou

Chen

et al. 2003

Journal of Chromatography A

137

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“…The molar ratio of the template to functional monomer (T/M) has been found to be important to the number and quality of MIP recognition sites [22]. A series of polymers (P3, P4, P5) were synthesized by changing the T/M ratio and applied into the chiral separation of DABN racemate.…”

Section: Resultsmentioning

confidence: 99%

Preparation of molecularly imprinted polymer for chiral recognition of racemic 1,1′-binaphthalene-2,2′-diamine by HPLC

Dong¹,

Wang²,

Ou³

et al. 2014

Acta Chromatographica

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Summary. Molecularly imprinted polymers (MIPs) were synthesized by imprinting a new template-S-(-)-1,1′-binaphthalene-2,2′-diamine (S-DABN) and applied as chiral stationary phases for chiral separation of DABN racemates by high-performance liquid chromatography (HPLC). The influence of some key factors on the chiral recognition ability of MIPs, such as the type of functional monomers and porogen and the molar ratio of template to monomer, was systematically investigated. The chromatographic conditions, such as mobile phase composition, sample loading, and flow rate, were also measured. The chiral separation for DABN racemates under the optimum chromatographic conditions by using MIP chiral stationary phase (CSP) of P3, prepared with the S-DABN/MAA ratio = 1/4 and used acetonitrile (2 mL) and chloroform (4 mL) as porogen, showed the highest separation factor (2.14). Frontal analysis was used to evaluate affinity to the target molecule of MIPs. The binding sites (B t ) of MIPs and dissociation constant (K d ) were estimated as 4.56 μmol g −1 and 1.40 mmol L −1 , respectively. In comparison with the previous studies, this approach had the advantages, such as the higher separation factor, easy preparation, and cost-effectiveness, it not only has the value for research but also has a potential in industrial application.

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Study of the nature of recognition in molecularly imprinted polymers, II

Cited by 167 publications

References 29 publications

Non-covalent imprinting of phosphorous esters

Non-covalent imprinting of phosphorous esters

Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers

Preparation of molecularly imprinted polymer for chiral recognition of racemic 1,1′-binaphthalene-2,2′-diamine by HPLC

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