Study of the phenolic compound profile and antioxidant activity of human milk from Spanish women at different stages of lactation: A comparison with infant formulas

Sánchez-Hernández, Silvia; Esteban-Muñoz, Adelaida; Samaniego‐Sánchez, Cristina; Giménez-Martínez, Rafael; Miralles, Beatriz; Herrera, Manuela

doi:10.1016/j.foodres.2021.110149

Cited by 17 publications

(7 citation statements)

References 58 publications

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“…The literature is very heterogeneous concerning the effect of HoP on milk TAC, with reports of a reduction in or even absence of effects [ 14 ]. As clearly demonstrated by Sanchez-Hernandez et al [ 26 ], these discrepancies might be due to the different methods used for TAC evaluation. Indeed, milk TAC is mostly evaluated by chemical assays, based on a single electron transfer reaction (SET).…”

Section: Discussionmentioning

confidence: 97%

In Vivo Assessment of Antioxidant Potential of Human Milk Treated by Holder Pasteurization or High Hydrostatic Pressure Processing: A Preliminary Study on Intestinal and Hepatic Markers in Adult Mice

et al. 2022

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Preterm infants are highly susceptible to oxidative stress due to an imbalance between endogenous oxidant and antioxidant systems. In addition, these newborns are frequently fed with donor milk (DM) treated by Holder pasteurization (HoP) at 62.5 °C for 30 min, which is known to alter numerous heat-sensitive factors, including some antioxidants. High hydrostatic pressure (HHP) processing was recently proposed as an innovative method for the treatment of DM. The present study aimed to measure the redox balance of HoP- and HHP-DM and to study, in vivo, the effects of HoP- and HHP-DM on the gut and liver. H2O2, vitamin A and vitamin E (α- and γ-tocopherols) concentrations, as well as the total antioxidant capacity (TAC), were measured in raw-, HoP- and HHP-DM. The gene expression level of antioxidant systems and inflammatory response were quantified in the ileum and liver of adult mice after 7 days of oral administration of HoP- or HHP-DM. HoP reduced the γ-tocopherol level, whereas HHP treatment preserved all vitamins close to the raw milk level. The milk H2O2 content was reduced by HHP but not by HoP. The total antioxidant capacity of DM was reduced after HHP processing measured by PAOT-Liquid® technology but was unaffected after measurement by ORAC assay. In mice, HHP-DM administration induced a stimulation of antioxidant defenses and reduced some inflammatory markers in both the ileum and liver compared to HoP-DM treatment. Our preliminary study suggests that the HHP processing of DM may better protect preterm infants from gut and liver pathologies compared to HoP, which is currently used in most human milk banks.

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Section: Discussionmentioning

confidence: 97%

In Vivo Assessment of Antioxidant Potential of Human Milk Treated by Holder Pasteurization or High Hydrostatic Pressure Processing: A Preliminary Study on Intestinal and Hepatic Markers in Adult Mice

et al. 2022

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“…A recent comparative study found that the BM of mothers adhering to the MedDiet contained twice as many phenolic compounds as infant formula. However, MedDiet intervention had no effect on total phenolic compound content (TPC) and TAC of the BM during the lactation stages [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

A Mediterranean diet is associated with improved total antioxidant content of human breast milk and infant urine

Karbasi

Mohamadian

Naseri

et al. 2023

Nutr J

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Background The composition of breast milk (BM) is dynamic and can be influenced by maternal variables that include the diet and nutritional status. This study examined the association between maternal adherence to a Mediterranean diet (MedDiet) and total antioxidant content of BM and infant urine. Methods We collected 350 BM samples from mothers and urine samples from their infants. The dietary intakes of the mothers were recorded using a validated 65 items-food frequency questionnaire (FFQ). The total antioxidant status of the samples was assessed using the ferric reducing/antioxidant power (FRAP), the 1, 1-diphenyl-2-picrylhydrazyl (DPPH), thiobarbituric acid reactive substances (TBARS), and thiol quantification assays. Milk protein, calcium, and triglyceride (TG) were also determined using standard biochemical kits. Results Subjects with the highest MedDiet scores were among the women in the highest tertile (T3) for consumption of dietary fiber, fruits, vegetables, nuts, legumes, and seeds, low-fat dairy, whole grains, and the lowest consumption of red meat, sweetened beverages, and sodium, compared to women in the first tertile (T1) with the lowest MedDiet scores. After adjustment for potential confounders, the individuals in the highest tertile for MedDiet score had a significantly higher level of milk DPPH, and infant urinary DPPH than the lowest tertile and had a significantly higher level of milk protein, FRAP and infant urinary FRAP compared to the T2 (P < 0.05). In addition, the mothers in the T3 for the MedDiet pattern had a significantly lower level of milk TG compared to those within the T1 (P < 0.05). Conclusion Our findings show that a high maternal adherence to a MedDiet can affect BM composition and their infants' urine.

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“…Meanwhile, Sánchez-Hernández et al , showed differences in the average amount of total (poly)phenols present in colostrum, transitional and matured milk, 661, 773 and 652 µg/100 mL respectively, of free-living individuals in comparison with infant formula, 375 µg/100 mL, (9). Noteworthy, this reflects in general on a 2-fold increase in total (poly)phenol content in human breast milk in comparison with formula milk (only 375 µg/100 mL), reflecting that formula milk does not recapitulate complete human breast milk concerning (poly)phenol content.…”

Section: (Poly)phenolic Content In Human Breast Milkmentioning

confidence: 99%

“…Thousands of different dietary phytochemicals have been identified in human breast milk, of which carotenoids and (poly)phenols (9), represent by far the largest groups (10,11). In this study, we focused on the role of (poly)phenols such as phenolic acids, flavonoids, stilbenes, coumarins, lignans, and tannins (Figure 1) and their host and microbial metabolites for their well-documented protective and health-promoting properties, which are less understood compared to carotenoids (12).…”

Section: Introductionmentioning

confidence: 99%

(Poly)phenols in Human Breast Milk and their health benefits for the newborn

Carregosa

Silva

Teixeira

et al. 2023

Preprint

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Human breast milk is the first food source available to newborns and is responsible for healthy growth and development during the first months of life. Human breast milk contains vitamins, hormones, cytokines, microbiota, and immune cells that are responsible for such healthy conditions. Nonetheless, knowledge of the vast array of molecules present in human breast milk and their potential health effects is still lacking. The effects of mothers diets on the molecules present in human breast milk are also generally unknown. The health benefits of (poly)phenols have been largely increasing but their presence in breast milk has been put largely aside. The impact of the mothers diet in the presence and quantification of these molecules in milk has also been overlooked. Above all, the potential benefits of (poly)phenols for newborns are just a vast emptiness of what is known about (poly)phenol research.

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Study of the phenolic compound profile and antioxidant activity of human milk from Spanish women at different stages of lactation: A comparison with infant formulas

Cited by 17 publications

References 58 publications

In Vivo Assessment of Antioxidant Potential of Human Milk Treated by Holder Pasteurization or High Hydrostatic Pressure Processing: A Preliminary Study on Intestinal and Hepatic Markers in Adult Mice

In Vivo Assessment of Antioxidant Potential of Human Milk Treated by Holder Pasteurization or High Hydrostatic Pressure Processing: A Preliminary Study on Intestinal and Hepatic Markers in Adult Mice

A Mediterranean diet is associated with improved total antioxidant content of human breast milk and infant urine

(Poly)phenols in Human Breast Milk and their health benefits for the newborn

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