Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid]

Combination of Photodynamic Therapy with Anti-Cancer Agents

“…These molecules exert a powerful inhibitory effect on oxygen consumption, aerobic glycolysis and lactate transport and accumulation of neoplastic cells [67,68]. Shevchuk and co-workers [69,70] showed a potentiating anti-tumor action of 5-ALA-based-PDT when administered together with these agents. V79 Chinese hamster lung fibroblast cells were preincubated with lonidamine or levamisol jointly with 5-ALA for 4 hours prior to irradiation, or first treated with 5-ALAbased-PDT followed by the incubation with any of the two inhibitors 24 hours post-irradiation.…”

On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative

“…However, further experiments showed that the cells contain a sufficient amount of the photooxidizable PUFA. Indeed, the treatment of EAC cells with 0.25 mM LND, an antitumour agent having photosensitizing activity (Chekulayev et al, 1997), for 10 min followed by 50 min exposure to 89 OLJKW max = 330 nm) induced a 6-fold increase in the formation of MDA (Fig. 4).…”

Biomolecular Interaction and Photohemolytic Effect of Gold Nanoparticles

“…The spectra (Figure 2) clearly shows there occurs a slight broadening in the absorption spectrum of the GNPs as the concentration, as the hemoglobin increases and there is no shift in the absorption maxima. A high efficiency of excitation of surface plasmon waves (SPWs) on the GNPs surface allows their use in the development of biosensors [15] and in medical photothermal therapy [16]. The fluorescence spectra of a protein is usually studied with the fluorescing amino acids Tryptophan or Tyrosine in our study.…”