STUDY OF THE POSSIBILITY OF USING OF COLLOIDAL QUANTUM DOTS BASED ON AgInS2/ZnS FOR FLUORESCENCE IMAGING IN COMPARISON WITH FLUOROPHORES FIXED ON THE SURFACE OF THE NANOPARTICLES

Istomina, Maria S.; Королев, Д. В.; Почкаева, Е. И.; Mazing, D. S.; Мошников, В. А.; Гареев, К. Г.; Babikova, K. Yu.; Postnov, V. N.

doi:10.18705/2311-4495-2017-4-4-56-65

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…There is a fundamental opportunity of using chitosan nanoparticles (NPC) as markers for in vitro and in vivo imaging in those areas of the body, where the vascular permeability changes dramatically. For this purpose, they are coated with fluorescent dyes, such as indocyanine green, fluorescein, or colloidal quantum dots [48,49].…”

Section: Synthesis and Functionalization Of Nanomaterials 21 Immobilmentioning

confidence: 99%

Fluorescent Nanoagents for Biomedical Applications

Королев¹,

Istomina²,

Belоrus³

et al. 2020

Fluorescence Methods for Investigation of Living Cells and Microorganisms

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Fluorescence imaging is a promising method widely used for the evaluation of the biodistribution and accumulation of various fluorescent agents cross-linked to the drug for effective therapy control. This work presents the methods for the functionalization of nanomaterials to provide them with fluorescent properties. The first of these methods is a unique technology for producing porous silicon with fluorescent properties. The second approach demonstrates linking of the fluorophores to inorganic nanoparticles (NP) using a spacer molecule ending with a functional group. For all these examples of fluorophores, biodistribution studies were performed with the fluorescent imaging system IVIS Lumina LT III (PerkinElmer, USA). It was noted that the size of particles and the method of their injection affect the distribution and accumulation in organs. The resulting materials can be used to develop platforms for theranostics.

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Section: Synthesis and Functionalization Of Nanomaterials 21 Immobilmentioning

confidence: 99%

Fluorescent Nanoagents for Biomedical Applications

Королев¹,

Istomina²,

Belоrus³

et al. 2020

Fluorescence Methods for Investigation of Living Cells and Microorganisms

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“…In addition, colloidal QDs also have the advantage of a low elimination time from the body [ 22 ]. It was demonstrated in [ 23 ] that, on average, the half-life of QDs from the body of mice is no more than one week after a single intravenous injection. These characteristics may also increase the effectiveness of therapy due to the absence of the need for constant PS injections before the cure for multiple FD and PDT.…”

Section: Introductionmentioning

confidence: 99%

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

et al. 2022

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Today, fluorescent diagnostics and photodynamic therapy are promising methods for diagnosing and treating oncological diseases. The development of new photosensitizers (PS) is one of the most important tasks to improve the efficiency of both laser-induced diagnostics and therapy. In our study, we conjugated PS with AIS/ZnS triple quantum dots (QDs) to obtain non-aggregated complexes. It was shown that the conjugation of PS with QDs does not change the PS fluorescence lifetime, which is a marker of the preservation of PS photophysical properties. In particular, efficient resonant Förster energy transfer (FRET), from QDs to PS molecules in the conjugate, increases the PS luminescence response. The FRET from QD to PS molecules with different ratios of donor and acceptors are shown. It has been demonstrated that the average efficiency of FRET depends on the ratio of PS and QD and reaches a maximum value of 80% at a ratio of 6 PS molecules per 1 QD molecule. Thus, these studies could help to contribute to the development of new complexes based on QD and PS to improve the efficiency of phototheranostics.

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ZAIS-based colloidal QDs as fluorescent labels for theranostics: physical properties, biodistribution and biocompatibility

Istomina

Pechnikova

Королев

et al. 2018

BRSMU

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In recent years there has been an increase in interest in the use of colloidal quantum dots (QDs) in biology and medicine. In particular, QDs can be a perspective nanoscale object for theranostics, in which due to the specific accumulation of drug-loaded QDs in the pathological focus, its simultaneous visualization and targeted therapeutic influence occur. One of the serious limitations of the use of QDs in medicine is their potential toxicity, especially when the nanocrystal material contains elements such as cadmium or plumbum. Therefore, it is promising to develop labels based on QDs of relatively less toxic semiconductors of group I-III-VI, such as CuInS2 and AgInS2. In this study, biodistribution and biocompatibility of QDs based on the AgInS2 compound with a ZnS shell (ZAIS) are considered. In the study of biodistribution, the accumulation of QDs in organs such as liver, lungs, heart and kidneys was revealed. It was shown that QDs in the dose range from 2 • 10–7 to 4 • 10–6 M/L at intravenous administration in rats does not have a significant effect on body mass dynamics and basic hematological parameters for 30 days. Thus, ZAIS QDs can be used to visualize tissues and organs in various pathological processes, and immobilization of the drugs on their surface will allow to approach their application for theranostics.

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STUDY OF THE POSSIBILITY OF USING OF COLLOIDAL QUANTUM DOTS BASED ON AgInS2/ZnS FOR FLUORESCENCE IMAGING IN COMPARISON WITH FLUOROPHORES FIXED ON THE SURFACE OF THE NANOPARTICLES

Cited by 4 publications

References 14 publications

Fluorescent Nanoagents for Biomedical Applications

Fluorescent Nanoagents for Biomedical Applications

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

ZAIS-based colloidal QDs as fluorescent labels for theranostics: physical properties, biodistribution and biocompatibility

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