Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation

Roaiah, Mohamed Farid; Elkhayat, Yasser Ibrahim; Rashed, Laila Ahmed; Din, Sameh Fayek GamalEl; Guindi, A. M. el; Salam, Mohamed Ahmed Abd El

doi:10.1111/and.12855

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…Schmitt et al () showed that 5‐HT reuptake could also take the place of dopamine (DA) and noradrenaline (NE) transporters, which could affect extracellular 5‐HT levels. Several studies revealed that alterations in 5‐HT receptors were also important in sexual performance (Alvarez, Perez, & Artigas, ; Chan et al, ; Foreman, Hall, & Love, ; Roaiah et al, ; Schijven, Sousa, Roelofs, Olivier, & Olivier, ). Hence, the ejaculation reflex may be under the control of interactions between genes and environmental factors (Jannini, Burri, Jern, & Novelli, ; Jannini, Ciocca, et al, ; Jannini, Mario, & Andrea, ).…”

Section: Discussionmentioning

confidence: 99%

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

et al. 2019

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To explore the correlation between SERT expression and sexual activities and seek the possible mechanism of SERT in regulating ejaculations, we analysed the sexual activities and biochemical characteristics of five measured neural regions in three rat genotypes (SERT−/−, SERT+/− and SERT+/+). The results showed the SERT−/− group showed fewer ejaculations and a longer ejaculation latency than the SERT+/+ group, while the SERT+/− group did not differ significantly from the SERT+/+ group in sexual performance. In addition, the SERT−/− group showed an almost complete absence of SERT mRNA and protein expression in all measured regions. In the SERT+/− group, the SERT mRNA and SERT protein expressions were downregulated by approximately 50% and 35%, respectively, compared to the SERT+/+ group. The SERT−/− group had the highest 5‐HT levels, and the 5‐HT level in the SERT+/− group was between the other two groups. Besides, the 5‐HT levels differed in almost all measured regions of the three groups. Therefore, our study confirmed that SERT played a key role in sexual performance. A certain amount of SERT protein may be critical to normal sexual performance. Hence, Polymorphisms of the SERT gene should still be highlighted for ejaculation regulation research.

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Section: Discussionmentioning

confidence: 99%

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

et al. 2019

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“…PE is also considered as a learned pattern of rapid ejaculation maintained by anxiety about sexual failure (Mccabe, 2005). Previous studies demonstrated that PE was associated with the dysfunction of 5‐hydroxytryptamine (5‐HT) pathway in the brain, which included the hypersensitivity of 5‐HT 1A receptor, as well as the hyposensitivity of 5‐HT 2C receptor (Roaiah et al, 2018; Roaiah et al, 2019). 5‐HT system in the central system is associated with the regulation of emotional processing (Stiedl et al, 2015; Wolf et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Increased attentional network activity in premature ejaculation patients with anxiety revealed by resting‐state functional magnetic resonance imaging

Liu

Zhang

Wang

et al. 2021

Eur J of Neuroscience

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Psychological account hypothesizes that premature ejaculation (PE) is a learned pattern of rapid ejaculation maintained by anxiety about sexual failure, whereas neuropsychological accounts hypothesizes that PE is the result of dysfunction of central nervous system regulating ejaculatory. However, the central neural mechanism underlying PE patients with anxiety remains unclear. Resting‐state functional magnetic resonance imaging (fMRI) data were collected in 20 PE (diagnoses based on PE Guidelines drafted by the International Society for Sexual Medicine [ISSM]) patients with anxiety and 25 matched healthy controls (HCs) from January 2019 to December 2020. The values of fractional amplitude of low‐frequency fluctuation (fALFF) were compared between groups. Moreover, the correlations between fALFF and the severity of PE and anxiety of patients were examined. PE patients with anxiety had increased fALFF values in the right inferior frontal gyrus (opercular part) and middle frontal gyrus. In addition, significant positive correlations were found between the scores of PE diagnostic tool (PEDT) and fALFF values of the right inferior frontal gyrus (opercular part), as well as the right middle frontal gyrus. Moreover, fALFF values of the right inferior frontal gyrus (opercular part) and middle frontal gyrus were positively correlated with the scores of self‐rating anxiety scale (SAS). Our results suggested that increased attentional network activity might play a critical role in the neural basis of PE patients with anxiety.

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“…Different 5‐HT receptors have different biological functions: 5‐HT2C receptor can inhibit ejaculation, while 5‐HT1A receptor can promote ejaculation. Therefore, 5‐HT, 5‐HTT, and 5‐HT receptors are closely related to the occurrence of PE 48 …”

Section: Discussionmentioning

confidence: 99%

Selective serotonin reuptake inhibitors combined with traditional Chinese medicine for premature ejaculation: A systematic review and meta‐analysis

Chang

Chen

et al. 2022

Andrology

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Background Premature ejaculation (PE) is still a tough problem in drug treatment. Many clinical trials have proven that traditional Chinese medicine (TCM) has a significant effect in the treatment of PE. This article aims to provide the latest evidence for the efficacy and safety of TCM combined with selective serotonin reuptake inhibitors (SSRIs) in the treatment of PE. Methods We looked for randomized controlled trials (RCTs) from China National Knowledge Infrastructure, Wanfang, VIP Database, MEDLINE, PubMed, Web of Science, EMBASE, and Cochrane Library until June 30, 2022. STATA 15.1 software was used to analyze all data for this article. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3. Results Finally, we selected 16 high‐quality RCTs in our meta‐analysis, which containing 889 patients. Meta‐analysis suggested that, compared with SSRIs alone, combination of TCM with SSRIs increased significantly intravaginal ejaculation latencv time and the scores of ejaculation control ability, sexual life satisfaction, PE‐related distress, and communication difficulties between partners related to PE. Also, there was no significant difference in adverse effects between the two groups. In addition, the results of publication bias test showed that no significant bias occurred. Conclusion The combined use of TCM and SSRIs has significant effect in the treatment of PE compared with SSRIs monotherapy and was generally well tolerated. Due to the small sample size, multicenter and large sample RCT is still needed in the future to further confirm the effectiveness and safety of TCM combined with SSRIs in the treatment of PE.

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Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation

Cited by 16 publications

References 26 publications

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

Increased attentional network activity in premature ejaculation patients with anxiety revealed by resting‐state functional magnetic resonance imaging

Selective serotonin reuptake inhibitors combined with traditional Chinese medicine for premature ejaculation: A systematic review and meta‐analysis

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