Study of the protective effect of vitamin C on testicular tissue following experimental unilateral cryptorchidism in rats

Azari, Omid; Gholipour, Hojjat; Kheirandish, Reza; Babaei, Homayoon; Emadi, Ladan

doi:10.1111/and.12106

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Administration of DLRC only recorded the highest value of normal sperm morphology and near normal morphological defects when compared to the control group emphasized the health benefits of DLRC in promoting spermatogenesis and steriodogenesis via the action of glutathione [ 50 ]. Abnormal sperm morphology in Vit.C and DRLC + Vit.C co-treated rats staged a near normal return to normal sperm morphology due to the antioxidative efficacy of DRLC and Vit.C in scavenging free radicals supporting previous observation on their protective effects [ 51 , 52 ].…”

Section: Discussionsupporting

confidence: 90%

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

et al. 2021

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Background Cisplatin (CN) is considered as a cytotoxic agent and DNA synthesis inhibitor. D-Ribose- l -Cysteine (DRLC) is an active ingredient of riboceine, help cells to produce glutathione on body demand. Aim Current study focused on ameliorating potential and fertility enhancing activities of D-Ribose– l -Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration. Materials and method Sixty (60) male rats randomized into six groups of ten (n = 10) rats each. Group A (control) received 2.0 ml distilled water, group B received single dose of 8 mg/kg bwt CN, group C received 30 mg/kg bwt DRLC, group D received single dose of 8 mg/kg CN follow by 30 mg/kg bwt DRLC, group E received single dose of 8 mg/kg CN and vitamin C, group F received single dose of 8 mg/kg cisplatin follow by DRLC + Vit.C for 56 days. Parameters tested include: Sperm parameters, testosterone (TT), luteinizing hormone (LH), Follicle stimulating Hormone, (FSH), Prolactin, and testicular 17β-HSD activity, Blood hydroperoxide (BHP), Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT), testicular histology and fertility test. Results Cisplatin significantly reduced testicular volume, body weight, sperm quality, fertility indices, TT, FSH, LH, 17β-HSD, SOD, GSH, CAT, diameter and cross-sectional area of seminiferous tubules, spermatogenesis score. And elevate prolactin, testicular injury score, BHP and MDA compared with control group. Cisplatin only treated rats showed degenerated seminiferous epithelium with empty lumen. Intervention of D-Ribose-Cysteine ameliorated toxic impacts of CN on testis and improved the male fertility. Conclusion D-Ribose- l -Cysteine therefore, preserves testicular integrity and functions thereby, preventing the deleterious impact of CN.

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Section: Discussionsupporting

confidence: 90%

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

et al. 2021

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“…33,34 Similarly, flavonoids and procyanidins (epicatechin, catechin, and procyanidins) present in cocoa suppress the expression of enzymes involved in oxidative damage to the testes, such as 8OH2 dG (8-hydroxy-2-deoxyguanosine), thereby preserving testicular morphology. 35 Observations made in this study suggest that early weaning can alter the testicular histoarchitecture, which can impair sperm production in adulthood. Therefore, cocoa powder supplementation could be effective in the protection of testicular morphology, and consequently, ensuring the reproductive health during adulthood.…”

Section: Discussionmentioning

confidence: 63%

Effect of maternal and postnatal cocoa supplementation on testicles of adult Wistar rats

Lima

Cardoso²,

Rocha³

et al. 2020

J Dev Orig Health Dis

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Early weaning can lead to changes in the morphology of organs in adulthood, and the consumption of functional foods during lactation and postnatal life is believed to prevent these changes. However, it is not known if early weaning affects testicular morphology and if the use of cocoa can prevent that. We studied the effects of maternal and postnatal supplementation of cocoa powder on the testicular morphology of early weaned adult rats. The animals were divided into four groups (n = 6 each), control group, cocoa control group, early weaning (EW) group, and cocoa early weaning (EWCa) group, and were analyzed for 90 d, after which they were euthanized. The animals from the EW group showed a reduction in the tubular diameter and height of the seminiferous epithelium, a decrease in epithelial surface density (Sv), and an increase in the lumen and proper tunic. However, the animals from the EWCa group showed an increase in the diameter and height of the epithelium, an increase in the epithelium Sv, and a decrease in the lumen and the proper tunic. The early weaning promotes morphological changes in the testicles; however, supplementation with cocoa powder can preserve the testicular histoarchitecture.

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“…[8][9][10][11][12] This antioxidant plays a variety of functions, such as scavenging free radicals, restoring vitamin E, neutralizing reactive oxygen metabolites, and inhibiting DNA damage and genetic mutation. [8,[13][14][15][16] Vit-C is present inside the cells and extracellular matrix and is capable of neutralizing the spermicidal and genotoxic effects of various free radicals. [13,17] This vitamin exists in the testes, possibly playing a pivotal role in the testicular antioxidant defense system and facilitating spermatogenesis.…”

Section: Introductionmentioning

confidence: 99%

Utility of vitamin C in ameliorating citalopram‐induced testicular toxicity via modulating nitro‐oxidative stress and apoptosis in mice

Moradi,

Hashemian,

Fathi

et al. 2023

J Biochem & Molecular Tox

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There is a growing concern that antidepressant drugs impair sexual function and adversely impact spermatogenesis and male fertility. Vitamin C is a natural antioxidant that plays a vital role in the male reproductive system. The present study investigated the ameliorating potential of vitamin C against citalopram (CTL)‐evoked testicular toxicity and spermatogenesis impairment in mice. Mice were randomly divided into six groups: control, CTL, vitamin C 100, vitamin C 200, CTL plus vitamin C 100, and CTL plus vitamin C 200. Adult male mice were intraperitoneally (ip) injected with 10 mg/kg of CTL for 35 days with or without vitamin C. At the end of the study, body and testes weight, sperm parameters, histopathology of testes, testosterone level, testicular levels of malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC), and apoptosis (TUNEL assay) were evaluated. Our findings revealed that vitamin C restored spermatogenesis by improving sperm count, motility, viability, morphology, and chromatin integrity. Testosterone levels and testes histopathology were significantly improved in the vitamin C‐administrated groups. Furthermore, vitamin C administration markedly alleviated CTL‐induced nitro‐oxidative damage, enhancing TAC levels, and reducing NO and MDA levels. Whilst CTL therapy induced a significant increase in the number of TUNEL‐positive cells compared to the control, the administration of vitamin C significantly prevented the apoptotic effects of CTL. Together, vitamin C therapy protects against CTL‐induced testicular damage via mitigating nitro‐oxidative stress and apoptosis, which provides evidence for vitamin C as a beneficial therapy against antidepressant drug‐associated reproductive toxicity and male sub/infertility.

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Study of the protective effect of vitamin C on testicular tissue following experimental unilateral cryptorchidism in rats

Cited by 8 publications

References 40 publications

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

Effect of maternal and postnatal cocoa supplementation on testicles of adult Wistar rats

Utility of vitamin C in ameliorating citalopram‐induced testicular toxicity via modulating nitro‐oxidative stress and apoptosis in mice

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