Study of the Quality of Medical Therapy and Adherence in Patients with Chronic Heart Failure (According to the COMPLIANCE Study)

Huseynova, E. T.; Кутишенко, Н. П.; Lukina, Yu. V.; Толпыгина, С. Н.; Воронина, В. П.; Blagodatskih, S. V.; Драпкина, О. М.; Martsevich, S. Yu.

doi:10.20996/1819-6446-2021-10-10

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Основными критериями исследований приверженности врачей КР являются выбор и назначение ЛП с доказанной эффективностью, достижение целевых дозировок (например, у пациентов с хронической сердечной недостаточностью), целевых значений ряда показателей (артериального давления, холестерина липопротеинов низкой плотности, международного нормализованного отношения, гликированного гемоглобина и др.) [2,13,[23][24][25][26].…”

Section: результатыunclassified

Problematic issues and development of classifications of the main parameters of quality and adherence to pharmacotherapy. Part II: physician adherence to clinical guidelines and official drug labels

Lukina,

Kutishenko,

Martsevich

et al. 2024

Cardiovasc Ther Prev

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The second publication is presented, devoted to the classification of the main parameters of quality and adherence to pharmacotherapy. Despite the fact that patients play a central role in the problem of medical adherence, the role of attending physicians is extremely significant both in prescribing/non-prescribing proven effective and safe therapy, and in influencing patient medical adherence. This led to the identification of a special commitment type — the physician adherence to the basic principles of rational treatment. Collection, analysis and systematization of information, as well as the related development of a classification of physician adherence/non-adherence were the aim of this review and analytical work. We searched data using keywords among Russian and English-language sources. When compiling the classification, categories of adherence/non-adherence were identified in accordance with the implementation by physicians of the main provisions of clinical guidelines for long-term therapy for patients with non-communicable diseases (NCDs), as well as following official drug labels reflecting data on clinical pharmacology, the main side effects, drug-drug interactions. The classification of physician adherence/non-adherence to implementing the principles of rational treatment of patients with NCDs can be used in the development of electronic medical decision support systems for providing therapy with proven effectiveness and safety in specific clinical situations. In addition, on the basis of the developed classification, checklists for monitoring by healthcare specialists of the implementation of the rational treatment of patients with chronic NCDs should be created.

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Section: результатыunclassified

Problematic issues and development of classifications of the main parameters of quality and adherence to pharmacotherapy. Part II: physician adherence to clinical guidelines and official drug labels

Lukina,

Kutishenko,

Martsevich

et al. 2024

Cardiovasc Ther Prev

Self Cite

View full text Add to dashboard Cite

show abstract

“…МНЕНИЕ ПО ПРОБЛЕМЕ фармакотерапии, но и достижение целевых дозировок лекарственных препаратов, особенно, в группе "уязвимых" пациентов, к которым относятся и лица старшего возраста [38][39][40][41][42] (рис. 1).…”

Section: термины характеризующие приверженность лече нию факторы на н...unclassified

Adherence to treatment as an integral component of the management of patients with heart failure

Larina,

Zamyatin,

Sheregova

et al. 2023

Russ J Cardiol

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The problem of rational management of patients with heart failure (HF) remains extremely relevant due to its increasing incidence and poor prognosis. Based on current guidelines, therapy for patients with HF involves systematic and long-term use of many medications, and their effectiveness largely depends on the quality of the patient’s compliance. Pharmacotherapy of older patients with HF is complicated by metabolism and the coexistence of many diseases associated with polypharmacy, which significantly reduces the response to therapy. Insufficient adherence to treatment has been proven to reduce the quality of life of patients. Currently, three HF phenotypes have been identified, depending on the left ventricular ejection fraction. However, the number of studies examining the characteristics of patient adherence in different phenotypes is limited, which requires further research. The article is an analytical review devoted to various aspects of adherence to treatment in patients with HF. The terms and concepts associated with compliance, the history of its research, the main modern approaches to pharmacotherapy of HF for different phenotypes are briefly covered. The results of a number of large clinical studies are presented, including the assessment of adherence in patients with HF and its relationship with prognosis.

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Medication adherence in patients with heart failure: a pilot observational study in outpatient practice

Larina,

Zamyatin,

Gudiev

2024

Russ J Cardiol

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Aim. To assess clinical characteristics and medication adherence in patients with heart failure (HF) with different left ventricle ejection fractions (LVEF).Material and methods. The study involved 65 outpatients aged ≥60 years with a verified diagnosis of HF. A standard physical examination, laboratory and echocardiographic studies were performed. Adherence to treatment was assessed using the National Society of Evidence-B ased Pharmacotherapy Adherence Scale. A patient was considered to have complete adherence with a score of 0, incomplete adherence — ≥1.Results. Preserved LVEF (≥50%) was present in 33 (50,8%) patients (mean age, 76,2±6,6 years). Mildly reduced and reduced LVEF (<50%) was recorded in 32 (49,2%) patients aged 69,8±7,7 years. Regardless of the LVEF, all patients (100%) had two or more chronic diseases, while 45,5% of patients with LVEF ≥50% and 53,1% of patients with LVEF <50% took six or more medications. Most patients took beta-blockers (78,8% in the group with LVEF ≥50%; 87,5% in the group with LVEF <50%), while in isolated cases — angiotensin receptor- neprilysin inhibitors (3% of patients with preserved LVEF; 6,3% — with reduced and moderately reduced LVEF). At the same time, no patient with HF took quadruple therapy. Full adherence to treatment was found in 87,5% of patients in the group with LVEF <50% and in 57,6% in the group with LVEF ≥50%, p=0,007. As the leading reason for noncomplete adherence to treatment, most patients (61,1%) indicated forgetfulness.Conclusion. Complete adherence rate in outpatients with HF with preserved EF is lower than in patients with reduced and mildly reduced EF. Regardless of LVEF, patients with HF require measures to improve medication adherence

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Study of the Quality of Medical Therapy and Adherence in Patients with Chronic Heart Failure (According to the COMPLIANCE Study)

Cited by 4 publications

References 10 publications

Problematic issues and development of classifications of the main parameters of quality and adherence to pharmacotherapy. Part II: physician adherence to clinical guidelines and official drug labels

Problematic issues and development of classifications of the main parameters of quality and adherence to pharmacotherapy. Part II: physician adherence to clinical guidelines and official drug labels

Adherence to treatment as an integral component of the management of patients with heart failure

Medication adherence in patients with heart failure: a pilot observational study in outpatient practice

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