Forces acting on the body via various external surfaces during locomotion are needed to support the body under gravity, control posture, and overcome inertia. Examples include the forces acting on the body via the seating surfaces during wheelchair propulsion, the forces acting on the plantar foot tissues via the insole during gait, and the forces acting on the residual limb tissues via the prosthetic socket during various movement activities.Excessive exposure to unwarranted stresses at the body support interfaces could lead to tissue breakdowns commonly known as pressure ulcers, presented often as deep tissue injuries around bony prominences and/or surface damages on the skin. In this paper, we review the literatures on how the involved tissues respond to epidermal loadings, taking into account both experimental and computational findings from in-vivo and in-vitro studies. In particular, related literatures on internal tissue deformation and stresses, microcirculatory responses, as well as histological, cellular and molecular observations are discussed.