Study of the Renal Function in Nonrenal Organ Transplantation

González, Esther; Corte, Carmen Díaz; Molina, Beatriz Díaz; Diéguez, Luisa González; Suárez, Francisco Ortega; Grande, Jesús

doi:10.1016/j.transproceed.2006.08.181

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…Age at transplant has emerged as a risk factor in numerous studies (1, 5, 11, 16–19), even though the definition of renal dysfunction has varied considerably, from serum creatinine > 1.5 mg/dL (16) to GFR < 20 mL/min per 1.73 m 2 (19). Age is in fact expected to predict almost any GFR‐based concept of renal dysfunction, since GFR in the general population aged > 30 falls by about 1 mL/min per 1.73 m 2 per yr (4).…”

Section: Discussionmentioning

confidence: 99%

“…As noted above, female sex is also a risk factor for renal dysfunction that has been observed in many studies (4, 12, 17, 18), and which patients with HT “inherit” from the general population, where GFR is said to be around 8% less in women than in men (4). In the only study we know in which male sex rather than female sex emerged as a risk factor (16), this finding may have been related to the criterion for renal dysfunction having been very lax (serum creatinine > 1.5 mg/dL) and/or to all patients having had normal pre‐transplant serum creatinine values.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors associated with moderate‐to‐severe renal dysfunction among heart transplant patients: results from the CAPRI study

Delgado

Crespo‐Leiro

Gómez-Sánchez

et al. 2010

Clinical Transplantation

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The longer survival of patients with heart transplantation (HT) favors calcineurin inhibitor-related chronic kidney disease (CKD). It behoves to identify risk factors. At 14 Spanish centers, data on 1062 adult patients with HT (age 59.2 ± 12.3 yr, 82.5% men) were collected at routine follow-up examinations. Glomerular filtration rate, GFR, was estimated using the four-variable MDRD equation, and moderate-or-severe renal dysfunction (MSRD) was defined as K/DOQI stage 3 CKD or worse. Time since transplant ranged from one month to 22 yr (mean 6.7 yr). At assessment, 26.6% of patients were diabetic and 63.9% hypertensive; 53.9% were taking cyclosporine and 33.1% tacrolimus; and 61.4% had MSRD. Among patients on cyclosporine or tacrolimus at assessment, multivariate logistic regression identified male sex (OR 0.44), pre- and post-HT creatinine (2.73 and 3.13 per mg/dL), age at transplant (1.06 per yr), time since transplant (1.05 per yr), and tacrolimus (0.65) as independent positive or negative predictors of MSRD. It is concluded that female sex, pre- and one-month post-HT serum creatinine, age at transplant, time since transplant, and immunosuppression with cyclosporine rather than tacrolimus may all be risk factors for development of CKD ≥ stage 3 by patients with HT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factors associated with moderate‐to‐severe renal dysfunction among heart transplant patients: results from the CAPRI study

Delgado

Crespo‐Leiro

Gómez-Sánchez

et al. 2010

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“… 2 , 6 , 17 , 18 In contrast, others showed no correlation between hypertension, DM, hepatitis C seropositivity, and CKD. 10 , 19 Two studies suggested an association between increased BMI with CKD manifestations and specifically the development of secondary glomerulosclerosis. 19 , 20 It may very well be that increased patient weight contributes to renal damage through multiple pathways and should be kept in mind for transplant recipients both preoperatively and postoperatively.…”

Section: Discussionmentioning

confidence: 99%

“… 10 , 19 Two studies suggested an association between increased BMI with CKD manifestations and specifically the development of secondary glomerulosclerosis. 19 , 20 It may very well be that increased patient weight contributes to renal damage through multiple pathways and should be kept in mind for transplant recipients both preoperatively and postoperatively. In any case, the small cohort reported here prevents any definitive conclusion and another limitation is the fact that pretransplant comorbidities, which could potentially contribute to changes in renal function posttransplant, were not uniformly reported in the IR cohort.…”

Section: Discussionmentioning

confidence: 99%