Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Menegueti, Mayra Gonçalves; Pereira, Marcos Fernando; Bellissimo-Rodrigues, Fernando; Garcia, Tânia Marisa Pisi; Saber, Luciana Tanajura Santamaria; Nardim, Maria Estela Papini; Múglia, Valdir Antônio; Moysés-Neto, Miguel; Romão, Elen Almeida

doi:10.1590/0037-8682-0098-2015

Cited by 12 publications

(14 citation statements)

References 18 publications

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“…The present prevalence was quite smaller than the recent reports from different parts of the world. Shams et al, [24] in Iran, Becerra et al, [29] in the USA, Menegueti et al, [31] in Brazil, Elkehili et al, [32] in Libya and Ooms et al, [33] in Netherland reported as 22.7, 28, 26.2, 29.5 and 28%, respectively. On the other way, the highest incidence of UTI among renal transplant recipients was also reported by Khosravi et al, [7] in Iran, Gondos et al, [14] in Yemen, Alkatheri, [26] in Saudi Arabia that was 33.56, 33.5 and 55.5% respectively.…”

Section: Discussionmentioning

confidence: 99%

Bacterial urinary tract infection among adult renal transplant recipients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

et al. 2019

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Background: Despite significant advances in surgical techniques, immunosuppression protocols, follow up periods and antimicrobial stewardship in modern medicine; post-renal transplantation urinary tract infection remained a major public health problem globally. This multiple serious squeals includes asymptomatic bacteriuria, cystitis and pyelonephritis. Among these, the bacterial origin of infection complications accounts for the most significant clinical, socioeconomic impacts in many countries of the world. Therefore, the aim of the study was to investigate the prevalence of bacterial isolates that cause urinary tract infections, assess antibiotic susceptibility pattern among symptomatic and asymptomatic renal transplant recipients attending at

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Section: Discussionmentioning

confidence: 99%

Bacterial urinary tract infection among adult renal transplant recipients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

et al. 2019

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“…The present prevalence was quite smaller than the recent reports from different parts of the world. Shams et al, [24] in Iran , Becerra et al, [29] in the USA, Menegueti et al, [31] in Brazil, Elkehili et al, [32] in Libya and Ooms et al, [33] in Netherland reported as 22.7 %, 28 %, 26.2 %, 29.5% and 28%, respectively. Not surprisingly, the highest incidence of UTI among renal transplant recipients was also reported by Khosravi et al, [7] in Iran, Gondos et al, [14] in Yemen, Alkatheri, [26] in Saudi Arabia that was 33.56 %, 33.5 % and 55.5% respectively.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Urinary Tract Infection among Adult Renal Transplant Recipients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Kiros

Asrat

Ayenew

et al. 2019

Preprint

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Background: Despite significant advances in surgical techniques, immunosuppression protocols follow up periods and antimicrobial stewardship in modern medicine; post-renal transplantation urinary tract infection remained a major public health problem globally. This multiple serious squeal includes asymptomatic bacteriuria, cystitis and pyelonephritis. Among these, the bacterial origin of infection complications accounts for the most significant clinical, socio-economic impacts in many countries of the world. Therefore, the aim of the study was to investigate the prevalence of bacterial isolates that cause urinary tract infections, assess antibiotic susceptibility pattern among symptomatic and asymptomatic renal transplant recipients attending at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Methods: A hospital-based cross-sectional study was conducted from December 2017 to August 2018 among 74 renal transplant recipients St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. A first morning voided clean-catch mid-stream urine specimens were collected and 0.001ml inoculated onto blood and MacConkey agar plates following the standard bacteriological protocols. It was incubated aerobically at 35–37°C for 24–48 hours. Cultural characteristics and series of biochemical tests were used for the identification of isolates to species level. Results: Significant bacteriuria was found in 11/74 (14.9%, 95% CI =8.2-24.7) patients. The prevalence among females 6/32 (18.75%) was higher among males 5/42 (11.9%) without significant association (COR=2.09, 95% CI=1.04-8.45, P=0.253). Urinary tract infection was higher in the age group of 35–49 years old (19.3%). Age was statistically significant and stronger independent associated risk factor with crude odds ratio=3.67, 95% CI=2.89-20.07 and P= 0.003, respectively. The most prevalent bacteria isolates were Escherichia coli 2(18.2%), Staphylococcus aureus 2(18.2%), Acinetobacter spp. 2(18.2%), Enterococcus spp. 2(18.2%), Coagulase-negative Staphylococci 2(18.2%) followed by Portus mirabilis 1(9.1%). The majority (80%) of Gram-negative bacteria were resistant to ciprofloxacin, chloramphenicol, and trimethoprim/sulfamethoxazole. Conclusions: In conclusion, the overall prevalence of urinary tract infection in the study participants was relatively low with a prevalence of 14.9%. Majority of the study participants were asymptomatic. The multidrug-resistant bacterial isolates in the present study account for 82%. Keywords: Kidney Transplantation, Urinary Tract Infection, Antimicrobial Susceptibility Testing, St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.

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“…[ 9 ] Bacteria are the most common cause of postrenal transplant UTIs; fungi and viruses are less common;[ 10 11 ] Gram-negative organisms were the predominant pathogens in the early posttransplant period. [ 12 13 14 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

Risk factors for urinary tract infections in renal allograft recipients: Experience of a tertiary care center in Hyderabad, South India

et al. 2017

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Renal transplantation is an effective and commonly performed procedure for end-stage renal disease. Urinary tract infections are a major cause of morbidity and mortality in renal transplant patients. As data on postrenal transplant urinary tract infections from the Indian subcontinent are limited, the present study was conducted to estimate the burden of urinary tract infections in this vulnerable group of patients. This was a prospective study on patients undergoing renal transplantation in 2014 at our tertiary hospital in South India with a follow-up of 2 years to evaluate the risk factors for urinary tract infections. The prevalence of urinary tract infections was 41.9% with a male preponderance of 76.9%. Mean age of the 31 patients was 32.4 ± 10.2 years (range: 16–55 years). Gram-negative bacilli were the most common isolates with Escherichia coli being the predominant pathogen (53.3%). All the infections occurred within 1 year of transplantation with delayed graft function (P < 0.001; confidence interval [CI]: 29.0–96.3) and prolonged hospital stay (P = 0.0281; CI: 42.1–99.6) being the significant risk factors for acquiring urinary tract infections. Carbapenemase production was noted in 33.3% of isolates and all the Gram-negative organisms isolated in the 1st month of transplantation were carbapenem-resistant (CR) E. coli. The high rate of carbapenem-resistant organisms in the early posttransplant period is a point of concern, especially with cadaver transplants. Infection control practices and catheter care need to be strictly monitored to minimize the risk for UTI in the immediate posttransplant period.

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Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Cited by 12 publications

References 18 publications

Bacterial urinary tract infection among adult renal transplant recipients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Bacterial urinary tract infection among adult renal transplant recipients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Bacterial Urinary Tract Infection among Adult Renal Transplant Recipients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Risk factors for urinary tract infections in renal allograft recipients: Experience of a tertiary care center in Hyderabad, South India

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