Study of the role of IL-17F gene polymorphism in the development of immune thrombocytopenia among the Egyptian children

Botros, Shahira K. A.; Ibrahim, Ola M.; Gad, Alaa

doi:10.1016/j.ejmhg.2018.02.003

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…However, another study by Yousry et al [31] is in accordance with the present study, since it was found that Egyptian chronic ITP patients have a significantly higher frequency of the IL-17F TT genotype as compared with control individuals (84.1% versus 70.0%; OR = 2.269; p = 0.015). Furthermore, in contrast to the present results, Botros et al [32] has been shown to affect asthma susceptibility, being associated with a decreased risk of certain types of asthma. [8] The IL-17F gene has been demonstrated to play a role in ulcerative colitis [9], rheumatoid arthritis [10] [33], and recurrent Open Journal of Blood Diseases pregnancy loss [34].…”

Section: Discussioncontrasting

confidence: 99%

Association of IL-17A and IL-17F Gene Polymorphisms with Acute Immune Thrombocytopenia in Egyptian Children

Aziz¹,

Ahmed²,

Mahmoud³

et al. 2018

OJBD

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Background: IL-17 is an inflammatory cytokine that plays a crucial role in many autoimmune diseases. Aim: To investigate the association of IL-17A rs2275913 and IL-17F rs763780 gene polymorphisms with acute immune thrombocytopenic purpura (ITP) in Egyptian children. Patients and methods: We examined 80 patients (male/female, 33/47; median age, 7 years old) diagnosed with acute ITP and 55 healthy controls (male/female, 28/27; median age, 7 years old). Genotyping was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: In the acute ITP group compared to control, statistical analysis of the genotype frequencies (GG, AG, AA) of the IL-17A rs2275913 polymorphism and its alleles (A, G) showed no significant difference between the two groups (p > 0.05). Interestingly, the IL17A rs2275913 GG genotype was associated with early recovery (p = 0.04). As regard the genotype frequencies of the IL-17F rs763780 polymorphism, there was statistical significant difference in the TT and TC genotype frequencies between the case and control groups (p = 0.001 and p = 0.003, respectively). The number of IL-17F rs763780 T alleles was significantly higher in acute ITP patients as compared with children in the control group (p < 0.001). Conclusion: The present findings indicate that the IL-17 polymorphism IL-17F rs763780, but not IL-17A rs2275913 may be associated with a higher risk of acute ITP in Egyptian children.

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Section: Discussioncontrasting

confidence: 99%

Association of IL-17A and IL-17F Gene Polymorphisms with Acute Immune Thrombocytopenia in Egyptian Children

Aziz¹,

Ahmed²,

Mahmoud³

et al. 2018

OJBD

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“…These results agree with each of: (18) by showing that TT appearance was at a high rate, (19) by showing that TT genotypes were at a high appearance (38.8%) while CC showed (27.3%), (20) by showing that TT genotypes were at a high appearance (89.3%) while CC showed (0.7%), (21) by showing that TT genotypes were at a high appearance (97.0%) while CC showed (3%), (22,23,24,25,26) , show that TT appearance was at a high rate.…”

Section: Discussionsupporting

confidence: 89%

Genotype and Haplotype of Interleukin-17F (IL-17F) in Peptic Ulcer in Iraqi Patients

ZainabAkbal¹,

Abid²,

Al-Shareefi³

2020

MLU

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A peptic ulcer can be described as a condition in which there is a discontinuity in the entire thickness of the gastric mucosa. The discontinuity can also involve the submucosa, and in some cases, the deeper layers of the muscle wall (1) . Immunological serological and molecular factors play a great role in the susceptibility and diagnosis of this disease. IL-17F genotyping were reported to have an influencing in all types of peptic ulcer. The current study aims to detect some cytokine concentration (proinflammatory and Regulatory) in patients' blood, and some cytokine polymorphism. During the time from July 2019 to November 2019, the case-control study enrolled 318 blood samples collected from the patients who attended the Marjan Teaching Hospital-Hilla, as well as 60 healthy people. IL-17F genotyping was performing for 55 patients with peptic ulcer, and 30 healthy people as control, by using the PCR-SSP method. All types of peptic ulcers were significantly associated with IL-17F. Associations were also observed with IL-12A and IL-CXCR2. In conclusion, IL-17F, haplotypes, and genotypes have related to peptic ulcers so it can be dependent as a genetic marker for the susceptibility of this disease in Iraq.

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“…IL -17 is a proinflammatory cytokine that recruits different cell types to the site of inflammation and thus plays a protective role in infections. However, overproduction of IL -17 has been found in many autoimmune diseases [5]. In our study, the percentage of Th 17 cells was significantly higher in patients than in controls (1.85% versus 0.82%, p < 0.0001).…”

Section: Discussionsupporting

confidence: 38%

T helper 17 cells and interleukin-17 contribute to the pathogenesis of primary immune thrombocytopenia in Egyptian children: a single center experience.

Hassan

Abdel-Fattah²,

Esh³

et al. 2022

Zagazig University Medical Journal

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Background:Although the exact pathogenesis of primary immune thrombocytopenia (ITP) is still unclear, there are many research efforts directed toward the role of T helper 17 and interleukin 17 in the pathogenesis of this disease. The Th17 cell, which produces IL -17, is a subset of T helper cells. Interleukin 17 is a proinflammatory cytokine that has recently been shown to play a critical role in the development of autoimmune diseases. Our aim was to investigate the role of T helper cells 17 and interleukin-17 in the development of ITP in Egyptian children. Methods and results:This study was performed on 100 children with ITP and 100 healthy children as a control group. Patients underwent a complete history, a thorough physical examination, and routine investigations according to our local standards. The percentage of Th17 cells was measured in the study groups by flow cytometry. Serum IL -17 was also measured by ELISA in the study groups. Th17 cells were significantly higher in patients compared with controls. In addition, serum levels of IL -17 were observed to be 3.1-fold higher in patients with ITP compared to controls. Newly diagnosed patients had a significantly higher percentage of Th-17 cells as well as higher IL -17 levels than patients with persistent or chronic ITP. conclusion :We concluded that Th-17 cells and IL -17 contribute to the pathogenesis of ITP in Egyptian children.

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Study of the role of IL-17F gene polymorphism in the development of immune thrombocytopenia among the Egyptian children

Cited by 11 publications

References 21 publications

Association of IL-17A and IL-17F Gene Polymorphisms with Acute Immune Thrombocytopenia in Egyptian Children

Association of IL-17A and IL-17F Gene Polymorphisms with Acute Immune Thrombocytopenia in Egyptian Children

Genotype and Haplotype of Interleukin-17F (IL-17F) in Peptic Ulcer in Iraqi Patients

T helper 17 cells and interleukin-17 contribute to the pathogenesis of primary immune thrombocytopenia in Egyptian children: a single center experience.

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