Study of the stability of Kollidon® SR suspensions for pharmaceutical applications

Arias, José L.; Gómez-Gallo, Amparo; Delgado, A.V.; Gallardo, V.

doi:10.1016/j.colsurfa.2009.01.001

Cited by 18 publications

(18 citation statements)

References 14 publications

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“…peaks were identified as the main groups (Figure 4). 20,61 FTIR sptectra of pure materials were compared to KD1 and KD2 formulations and main signals were also detected in the spectra of formulations prepared therefore it showed that the formulation stages had no influence on the polymeric structure.…”

Section: Resultsmentioning

confidence: 99%

“…17 Kollidon ® SR has demonstrated to have no acute toxicity and to be not irritating to the skin or mucous membranes. 20 Kollidon ® SR contains no ionic groups therefore its sustained release properties are unaffected by ions or salts. 21 Considering the safety and the modification opportunities of the polymer novel application route for Kollidon ® SR was studied for the first time in this study for efficient treatment of ocular bacterial infections using dirithromycin.…”

Section: Kollidonmentioning

confidence: 99%

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Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Başaran¹

2017

tjps

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ÖZAmaç: Özellikle gözyaşı üretimi ve kırpma refleksleri gibi gözün koruyucu mekanizmalarına bağlı olarak göze topik olarak uygulanan formülasyonların göz yüzeyinden hızla uzaklaştırılması ve korneal yüzeyden verimsiz absorbsiyonu söz konusu olmaktadır. Prekorneal tutunma süresinin ve korneal permeabilitenin arttırılması ile oküler biyoyararlanımın arttırılmasında kolloidal ilaç taşıyıcı sistemler büyük önem taşımaktadır. Bu çalışmada antibakteriyel etkili bir madde olan diritromisin yüklü Kollidon ® SR yapılı polimerik nanopartiküller şiddetli oküler bakteriyel enfeksiyonların etkin tedavisi amacı ile hazırlanmıştır. Gereç ve Yöntemler: Bu çalışmada diritromisin Kollidon ® SR yapılı polimerik nanopartiküllere püskürterek kurutma yöntemi ile yüklenmiştir. Nanopartiküllerin in vitro karakteristik özellikleri üç farklı ortamda üç ay süresince detaylı olarak incelenmiştir. Bulgular: İn vitro analiz sonuçları parçacıkların üç aylık saklama süresince karakteristik özelliklerini koruduklarını göstermiştir. Sonuç: Kollidon ® SR yapılı polimerik nanopartiküllerin şiddetli oküler bakteriyel enfeksiyonların diritromisin ile tedavisinde oldukça etkili ilaç taşıyıcı sistem adayları olduklarını göstermiştir. Anahtar kelimeler: Diritromisin, Kollidon ® SR, polimerik nanopartiküller, oküler ilaç taşıyıcı sistemler Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon ® SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections. Materials and Methods: In this study, dirithromycin was incorporated into the Kollidon ® SR-based nanoparticles by spray drying method. In vitro characteristic properties were evaluated in detail during the storage period of three months at three different conditions. Results: The results of in vitro analyses revealed that characteristic properties of the particles were remained unchanged during the storage period of three months. Conclusion: Kollidon ® SR-based polymeric nanoparticles are good candidates for drug delivery systems in the treatment of severe ocular bacterial infections with dirithromycin.

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Section: Resultsmentioning

confidence: 99%

Section: Kollidonmentioning

confidence: 99%

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Başaran¹

2017

tjps

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“…Diferentes estudios han descrito el efecto que el pH del medio acuoso de dispersión puede tener sobre la carga eléctrica superficial de sólidos de interés farmacéutico, como pueden ser polímeros (11) o principios activos (13) . Por este motivo, se abordó en primer lugar el estudio de la influencia que el pH podría tener en las propiedades electroforéticas de las micropartículas de Praziquantel y su sedimentación cuando se encuentra en suspensión acuosa.…”

Section: Efecto Del Ph Sobre La Estabilidad De Las Suspensiones Acuosas De Praziquantelunclassified

“…Diversos estudios han descrito cómo el control de la composición del medio de dispersión permite definir las propiedades eléctricas superficiales de las suspensiones farmacéuticas, con la consiguiente importancia que esto puede tener en la obtención de sistemas floculados o defloculados según la vía de administración objetivo (11)(12)(13) .…”

Section: Introductionunclassified

Primeros estudios de preformulación en el desarrollo de una suspensión farmacéutica de micropartículas de Praziquantel destinada a la vía de administración oral

Badillo-García

Mediano

2019

Ars Pharm

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Introducción: Uno de los fármacos de primera línea en el tratamiento de la esquistosomiasis es el Praziquantel. Numerosas son las formas farmacéuticas sólidas orales desarrolladas hasta la fecha, siendo éstas poco adecuadas para determinados grupos de población, ej. tercera edad y Pediatría, y Veterinaria. Este trabajo describe los primeros pasos en el desarrollo de un estudio de preformulación dirigido al diseño de una forma farmacéutica líquida de administración oral para este principio activo. Método: Se caracterizó la forma y tamaño de las partículas de Praziquantel con las que se pretendía preparar una suspensión acuosa, mediante microscopía electrónica de barrido. Además, se analizó el efecto que el pH y el tipo de electrolito y su concentración tenían sobre el comportamiento de las suspensiones formuladas, gracias a medidas de electroforesis (potencial zeta) y espectrofotometría ultravioleta-visible (turbidimetría en función del tiempo). Resultados: La población de partículas de fármaco se caracterizó por una forma acicular y un tamaño micrométrico, con una distribución de tamaños heterogénea. Se comprobó cómo controlando la composición del medio de dispersión, en términos de pH y electrolitos, podía definirse la carga eléctrica superficial de las partículas de fármaco y, así su proceso de sedimentación, obteniéndose el sistema más adecuado para la vía de administración oral (sistema floculado). Conclusiones: Se han definido las condiciones iniciales de formulación de suspensiones acuosas de Praziquantel destinadas a la vía oral. Un control adecuado de la composición de la fase externa resulta fundamental en el establecimiento del mejor sistema (floculado) para esta vía de administración.

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“…1, 2 The relevant knowledge is also of great significance to several natural processes and technological applications, [3][4][5][6][7][8] such as pharmaceutical formulation, water and wastewater treatment, and material industries. Academically, ACRC plays an important role in understanding the mechanisms of colloidal stability and investigating fundamental inter-particle forces and hydrodynamic interactions.…”

Section: Introductionmentioning

confidence: 99%

A study on independently using static and dynamic light scattering methods to determine the coagulation rate

Zhou

et al. 2014

The Journal of Chemical Physics

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A first-passage scheme for determination of overall rate constants for non-diffusion-limited suspensions J. Chem. Phys. 116, 3128 (2002); 10.1063/1.1436119 This article is copyrighted as indicated in the article. Reuse of AIP content is subject to the terms at: http://scitation. Absolute coagulation rate constants were determined by independently, instead of simultaneously, using static and dynamic light scattering with the requested optical factors calculated by T-matrix method. The aggregating suspensions of latex particles with diameters of 500, 700, and 900 nm, that are all beyond validity limit of the traditional Rayleigh-Debye-Gans approximation, were adopted. The results from independent static and dynamic light scattering measurements were compared with those by simultaneously using static and dynamic light scattering; and three of them show good consistency. We found, theoretically and experimentally, that for independent static light scattering measurements there are blind scattering angles at that the scattering measurements become impossible and the number of blind angles increases rapidly with particle size. For independent dynamic light scattering measurements, however, there is no such a blind angle at all. A possible explanation of the observed phenomena is also presented. © 2014 AIP Publishing LLC.

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Study of the stability of Kollidon® SR suspensions for pharmaceutical applications

Cited by 18 publications

References 14 publications

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Primeros estudios de preformulación en el desarrollo de una suspensión farmacéutica de micropartículas de Praziquantel destinada a la vía de administración oral

A study on independently using static and dynamic light scattering methods to determine the coagulation rate

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