Study of the tidemark in human mandibular condylar cartilage

Chen, R.; Chen, S.; Chen, X.M.; Long, Xing

doi:10.1016/j.archoralbio.2011.04.007

Cited by 14 publications

(14 citation statements)

References 20 publications

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“…For examples, lithium-containing mesoporous bioglass was found to enhance osteochondral regeneration by stimulating bone MSC proliferation and osteogenic differentiation and by protecting chondrocytes and cartilage tissue in OA 35 . However, no biomaterial has yet been reported to completely retain the characteristics of native cartilage and subchondral bone tissue such as the tidemark, a histologically distinct basophilic boundary between non-calcified and calcified cartilage, which is a marker for cartilage maturation and regeneration 35,36 . Therefore, a decellularized osteochondral ECM scaffold that can maintain osteochondral hierarchy was generated to promote osteochondral regeneration.…”

Section: Discussionmentioning

confidence: 99%

Biphasic hierarchical extracellular matrix scaffold for osteochondral defect regeneration

Lin

Chen

Qiu

et al. 2018

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 99%

Biphasic hierarchical extracellular matrix scaffold for osteochondral defect regeneration

Lin

Chen

Qiu

et al. 2018

Osteoarthritis and Cartilage

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“…At the calcification front of the CZC, the tidemark has been found to be metabolically active in primary OA [ 23 ]. In the mandibular condyle, though it is fibrocartilage, tidemark appears wavy in load-bearing areas and relatively flat and smooth in non-load bearing areas [ 24 ], indicating the shape of tidemark is regulated to some extent by mechanical loading of the joint. Since biomechanical instability dominates PTOA pathology, the CZC pathology could be significant to the development of PTOA.…”

Section: Discussionmentioning

confidence: 99%

Pathology of the Calcified Zone of Articular Cartilage in Post-Traumatic Osteoarthritis in Rat Knees

2015

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ObjectivesThis study aimed to investigate the pathology occurring at the calcified zone of articular cartilage (CZC) in the joints afflicted with post-traumatic osteoarthritis (PTOA).MethodsRats underwent bilateral anterior cruciate ligament (ACL) transection and medial meniscectomy to induce PTOA. Sham surgery was performed on another five rats to serve as controls. The rats were euthanized after four weeks of surgery and tibial plateaus were dissected for histology. The pathology of PTOA, CZC area and the tidemark roughness at six pre-defined locations on the tibial plateaus were quantified by histomorphometry.ResultsPTOA developed in the knees, generally more severe at the medial plateau than the lateral plateau, of rats in the experimental group. The CZC area was unchanged in the PTOA joints, but the topographic variations of CZC areas that presented in the control knees were reduced in the PTOA joints. The tidemark roughness decreased in areas of the medial plateau of PTOA joints and that was inversely correlated with the Mankin’s score of PTOA pathology.ConclusionReduced tidemark roughness and unchanged CZC area differentiate PTOA from primary osteoarthritis, which is generally believed to have the opposite pathology at CZC, and may contribute to the distinct disease progression of the two entities of arthropathy.

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“…The tidemark, the basophilic line on articular cartilage sections separating uncalcified cartilage from calcified one, which was one of the representative markers for cartilage maturation [43], was clearly detectable in the repaired cartilage section at 52 weeks. Calcified cartilage below the tidemark forms an interface between the uncalcified cartilage and subchondral bone expresses collagen type X [44].…”

Section: Discussionmentioning

confidence: 99%

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

Zhang

Lian

et al. 2014

BioMed Research International

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Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ. However, the exact change of subchondral bone during osteochondral repair is still poorly understood. In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model. Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation. Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks. The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually. Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage. Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects. Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.

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Study of the tidemark in human mandibular condylar cartilage

Cited by 14 publications

References 20 publications

Biphasic hierarchical extracellular matrix scaffold for osteochondral defect regeneration

Biphasic hierarchical extracellular matrix scaffold for osteochondral defect regeneration

Pathology of the Calcified Zone of Articular Cartilage in Post-Traumatic Osteoarthritis in Rat Knees

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

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